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Anti Inflammatory Membranes for Implantable Biosensors

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
66321
Program Year/Program:
2003 / STTR
Agency Tracking Number:
DK065457
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
APPLIED TISSUE AND MATERIALS, INC.
APPLIED TISSUE AND MATERIALS, INC. 505 COAST BLVD S, STE 402 LA JOLLA, CA 92037 0461
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2003
Title: Anti Inflammatory Membranes for Implantable Biosensors
Agency: HHS
Contract: 1R41DK065457-01
Award Amount: $99,996.00
 

Abstract:

DESCRIPTION (provided by applicant): The prolonged inflammatory response to an implant is one of the primary causes for the failure to integrate implanted devices into tissue. The source of inflammation common to almost all implants is the foreign body response. Based on evidence in the literature and from our research team, the inflammatory response is mediated by the reactive oxygen species generated by macrophages, leukocytes, and the surrounding connective tissue. Based on our published findings, it is evident that titanium dioxide, even when present as surface coatings of polymeric biomaterials, has the ability to breakdown reactive oxygen species that have been identified as mediators of the inflammatory response. One device where the inflammatory response dramatically limits its clinical usefulness is the implanted glucose sensor. Here, there is a progressive loss of sensitivity caused by non-vascular fibrous tissue encapsulation. We propose to modify three different types of membranes used for implantable glucose sensors, by micropatterning coatings of titanium dioxide.

Principal Investigator:

Lars M. Bjursten
8584567500
LBURJSTEN@LJBI.ORG

Business Contact:


8584561342
Small Business Information at Submission:

Applied Tissue And Materials, Inc.
505 COAST BLVD S, STE 402 505 COAST BLVD S, STE 402 La Jolla, CA 92037

EIN/Tax ID: 731670103
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
LA JOLLA BIOENGINEERING INSTITUTE
505 COAST BLVD SOUTH
SAN DIEGO, CA 92037
RI Type: Domestic nonprofit research organization