USA flag logo/image

An Official Website of the United States Government

Preclinical Validation of Human Apyrase in Stroke Models

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
85939
Program Year/Program:
2007 / SBIR
Agency Tracking Number:
NS060175
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
APT THERAPEUTICS, INC.
4041 Forest Park Avenue SAINT LOUIS, MO -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2007
Title: Preclinical Validation of Human Apyrase in Stroke Models
Agency: HHS
Contract: 1R43NS060175-01
Award Amount: $187,435.00
 

Abstract:

DESCRIPTION (provided by applicant): Human apyrase represents a highly promising therapy for acute ischemic stroke which is a leading cause of death and disability with almost no effective therapy for most patients. This enzyme strongly inhibits platelet a ctivation and aggregation with modest bleeding risk. Using a protein informatics approach, we have successfully engineered a human apyrase, APT102, which exhibits significantly higher enzymatic activity and platelet inhibition than the wild-type apyrases. Importantly, APT102 conferred cerebroprotection against experimental stroke without inducing intracerebral hemorrhage. With the Phase I grant support, we will develop a process for high-yield purification of APT102. We will then utilize clinically relevant embolic model to validate whether APT102 provides significant neuroprotective effect without increased bleeding risk. Human apyrase represents a highly promising therapy for acute ischemic stroke. We will utilize a clinically relevant embolic model to val idate whether the protein provides significant neuroprotective effect without increased bleeding risk.

Principal Investigator:

Ridong Chen
3146086932
RCHEN@NIDUSCENTER.COM

Business Contact:

Ridong Chen
rchen@niduscenter.com
Small Business Information at Submission:

APT THERAPEUTICS, INC.
APT THERAPEUTICS, INC. 893 NORTH WARSON ROAD SAINT LOUIS, MO 63141

EIN/Tax ID: 431947715
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No