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BioPhalanx, a hand portable discrete monolithic microarray biothreat detector

Award Information

Department of Homeland Security
Award ID:
Program Year/Program:
2005 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
Arcxis Biotechnologies
18858 Carlton Ave Castro Valley, CA 94546-2908
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 2005
Title: BioPhalanx, a hand portable discrete monolithic microarray biothreat detector
Agency: DHS
Contract: NBCHC060031
Award Amount: $100,000.00


The focus of this proposal is to develop BioPhalanx a rapid, hand portable, robust detection system for multiplexed detection of bio-threats, in harsh environments. We have developed a new method of detection called Combinatorial Probe Analysis (CPA), which provides an exponential increase in detection reliability. This type of analysis will greatly reduce false positives and false negatives; in addition it is reusable and eliminates special storage requirements for reagents. The Arcxis Biotechnologies team has realized specific technical advancements in the optimization of hybridization assays for nucleic acid detection on porous polymer monoliths (PPM). We have further developed the ability to perform rapid and complete solubilisation of viruses, vegetative bacteria and bacterial spores with an ultra high temperature solubilisation protocol. Combining these proprietary technologies provides the ability to perform rapid highly multiplexed analysis of a variety of bioagents, including bacteria viruses, and protein biotoxins. The BioPhalanx system is designed to perform completely automated sample preparation and analysis, in a time frame of five minutes or less. The assay is simple in design allowing users in personal protective equipment to easily operate the system. In all, the proposed BioPhalanx system is robust, simple to use, and addresses the goals of DHS and the first responder community.

Principal Investigator:

Jay A. West
Acting CTO

Business Contact:

Jay A. West
Acting CTO and consultant
Small Business Information at Submission:

Arcxis Biotechnologies
18858 Carlton Avenue Castro Valley, CA 94546

EIN/Tax ID: 202355598
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No