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Instrumentation for Monitoring Breath Biomarkers for Diagnosis of Health,…

Award Information

Department of Defense
Air Force
Award ID:
Program Year/Program:
2004 / STTR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
Arete Associates
1550 Crystal Drive Suite 703 Arlington, VA 22202-4139
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 2004
Title: Instrumentation for Monitoring Breath Biomarkers for Diagnosis of Health, Condition, Toxic Exposure, and Disease
Agency / Branch: DOD / USAF
Contract: FA9550-04-C-0137
Award Amount: $100,000.00


Arete Associates and National Jewish Medical and Research Center propose to develop an instrument to measure the concentration of ethane in exhaled breath. The analyzer uses the combination of a proprietary hollow optical waveguide measurement cell, tunable semiconductor laser, and wavelength modulation spectroscopy to provide sensitive and reliable measurements of ethane. The sensor will exhibit rapid response time (<1s), low minimum detection limits (100's of parts per trillion) and will be physically compact relative to other sensors with similar sensitivity. The proposed project leverages our experience developing a mid infrared laser absorption spectrometer (MIRLAS) to monitor NO in exhaled breath. In Phase I, a benchtop measurement system will be constructed and tested. This system will be challenged with a variety of laboratory air mixtures. Phase II will consist of the development and optimization of a prototype instrument that will be used to monitor both NO and ethane in research trials with human subjects at NJMRC. Ethane and NO measurements will be verified using gas chromatographic and chemiluminescence techniques respectively.

Principal Investigator:

Gregory J. Fetzer
Deputy Division Director

Business Contact:

Patrick R. Manzo
Vice President
Small Business Information at Submission:

P.O. Box 6024 Sherman Oaks, CA 91413

EIN/Tax ID: 952954108
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
National Heart lung & Blood Institu
Building 31, Room 5A52, 31 Center Drive MSC 2486
Bethesda, MD 20892
Contact: Ephraim Johnson
Contact Phone: (301) 594-9529
RI Type: Domestic nonprofit research organization