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IDENTIFICATION OF HUMAN SQUAMOUS CELL CARCINOMA ANTIGENS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
39670
Program Year/Program:
1997 / SBIR
Agency Tracking Number:
39670
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Argonex, Inc.
2044 INDIA RD, STE 202 Charlottesville, VA 22903
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1997
Title: IDENTIFICATION OF HUMAN SQUAMOUS CELL CARCINOMA ANTIGENS
Agency: HHS
Contract: CA76818-01
Award Amount: $100,000.00
 

Abstract:

In the last several years there has been an explosion of information regarding the nature of peptide antigens expressed on human tumors together with class I molecules encoded in the Major Histocompatibility Complex (MHC) and recognized by cytotoxic T lymphocytes (CTL). One very successful approach aimed at the identification of these antigens, termed Direct Identification of Relevant Epitopes for Cancer Therapeutics or DIRECT TM, was developed by Argonex consultants. This technology involves the extraction and separation of class I MHC associated peptides, analysis for recognition of peptide-containing fractions using CTL from patients, and identification of the antigenic peptides by tandem mass spectrometry. In this Phase I application, we propose to employ DIRECT to isolate and identify one or more peptide antigens that are expressed on a human squamous cell cancer of the lung (SCCL) in the context of the human class I MHC molecule HLA-A68 and recognized by patient CTL. This research will lead to a more comprehensive analysis, using DIRECT, of antigens on SCCL recognized by CTL, including identification of the source proteins and an assessment of whether these or other peptides derived from the same proteins are recognized by CTL from other SCCL patients.

Principal Investigator:

Ross, mark m
0

Business Contact:


8049842040
Small Business Information at Submission:

Argonex, Inc.
2044 INDIA RD, STE 202 Charlottesville, VA 22903

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No