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A NEW DIAGNOSTIC TEST FOR SWINE DYSENTERY

Award Information

Agency:
Department of Agriculture
Branch:
N/A
Award ID:
10974
Program Year/Program:
1990 / SBIR
Agency Tracking Number:
10974
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Arizona Biotechnology Corp.
1430 E Ft Lowell #200 Tucson, AZ 85719
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1990
Title: A NEW DIAGNOSTIC TEST FOR SWINE DYSENTERY
Agency: USDA
Contract: N/A
Award Amount: $180,000.00
 

Abstract:

SWINE DYSENTERY (SD) HAS BEEN ESTIMATED TO COST SWINE PRODUCERS IN EXCESS OF 130 MILLION DOLLARS ANNUALLY, AND IS QUARANTINABLE IN MOST STATES. CONFIRMATION OF THE DISEASE IS BASED ON THE DETECTION OF THE BACTERIA, TREPONEMAHYODYSENTERIAE, FROM THE FECES OF INFECTED PIGS. THE CURRENTLY AVAILABLE ASSAY IS TIME CONSUMING, LACKS SENSITIVITY, AND IN MANY CASES REQUIRES AN EXPERIENCED TECHNICIAN FOR AN ACCURATE DIAGNOSIS. OUR GOAL IS TO DEVELOP AN EASILY INTERPRETED, RAPID AND SENSITIVE ASSAY TO DETECT THE ORGANISM FROM FECAL SAMPLES. RECOMBINANT DNA PROBES CAN BE USED FOR THE RAPID AND SENSITIVE INDENTIFICATION OF THE GENOME OF ANY ORGANISM. TWO PROBES FOR T. HYODYSENTERIAE WILL BE TESTED IN FECES FROM BOTH EXPERIMENTAL AND COMMERCIAL PIGS WITH SD TO DETERMINE THE FEASIBILITY OF DEVELOPING A GENE PROBE ASSAY FOR THE DIAGNOSIS OF THIS DISEASE. EXPERIMENTS ARE DESIGNED WHICH ADDRESS THE SPECIFIC DETECTION OF T. HYODYSENTERIAE IN FECESAND AMONG OTHER ENTERIC FLORA, THE SENSITIVITY OF THE DNA PROBE OR ITS ABILITY TO DETECT THE ASYMPTOMATIC "CARRIER" ANIMAL, AND THE COMPARISON OF THE DNA PROBE TO THE CURRENTLYAVAILABLE SELECTIVE CULTURE TECHNIQUE.

Principal Investigator:

Mary E Mapother
0

Business Contact:

Small Business Information at Submission:

Arizona Biotechnology Corp.
1745 N Campbell Ave #100 Tucson, AZ 85719

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No