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DRUG DEVELOPMENT OF AN ALZHEIMER'S DISEASE BRAIN SCAN

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
60404
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
AG020876
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ARMAGEN TECHNOLOGIES, INC.
26679 Agoura Rd. #100 Calabasas, CA -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: DRUG DEVELOPMENT OF AN ALZHEIMER'S DISEASE BRAIN SCAN
Agency: HHS
Contract: 1R43AG020876-01
Award Amount: $112,000.00
 

Abstract:

DESCRIPTION (provided by applicant):The goal of this work is the development of an Alzheimer' s disease (AD) diagnostic brain scan. AD is caused by the deposition of arnyloid in the brain and a diagnostic brain scan for AD could be developed if amyloid imaging agents were made transportable through the blood brain barrier (BBB). This work will prepare a genetically engineered fusion protein wherein the amyloid-imaging agent is fused to a monoclonal antibody (MAb) that undergoes receptor-mediated transport across the BBB in vivo. This MAb has been genetically engineered in past work to enable use in humans without immunological reaction. The fusion protein will be a bi-functional molecule that not only crosses the BBB, but also binds to the amyloid plaques of AD brain in vivo. The fusion gene will be prepared in phase I. The phase H work will produce a cell line secreting the fusion protein, and this protein will be purified per GMP requirements. The bi-functionality of the fusion protein will be confirmed by immunoassay. At the completion of the phase II work, the company will be able to submit an IND to the FDA for testing of this novel in vivo brain scan that will be the first diagnostic test specific for AD.

Principal Investigator:

Jian Y. Li
3104590163

Business Contact:

Jian Li
3104590163
RBOADO@MEDNET.UCLA.EDU
Small Business Information at Submission:

NEUROGENE TECHNOLOGIES, LLC
NEUROGENE TECHNOLOGIES, LLC 11301 OLYMPIC BLVD, STE 600 LOS ANGELES, CA 90064

EIN/Tax ID: 954874550
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No