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TITRATION ULTRASONIC ANALYZER

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
39458
Program Year/Program:
1997 / SBIR
Agency Tracking Number:
39458
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ARTANN LABORATORIES, INC.
1459 LOWER FERRY RD TRENTON, NJ -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1997
Title: TITRATION ULTRASONIC ANALYZER
Agency: HHS
Contract: GM56602-01
Award Amount: $98,302.00
 

Abstract:

This proposal relates to the emerging technique of high precision ultrasonic velocimetry that has provided unique and remarkable insights on bimolecular interactions. Often much of the driving force for macromolecular associations comes from reorganization of bound water. The unique sensitivity of sound velocity to changes in hydration makes it a powerful technique which can complement and sometimes surpass techniques such as isothermal titration calorimetry. Sound velocity monitored titrations can measure the affinity of binding of a macromolecule to a wide range of compounds, including drugs and other macromolecules. Exploitation of the technique has been hindered by the absence of commercial instrumentation with the precision, accuracy, sensitivity, and small sample volume required for biochemical studies. The goal of this proposal is to develop an ultrasonic velocimeter to analyze molecular association processes of biochemical and/or pharmaceutical importance. A prototype instrument, using a recently patented acoustic resonator, will be interfaced to a liquid delivery system. Software will be written to collect and analyze titration data. Evaluation of the prototype will include technical testing and calibration; laboratory testing with protein, carbohydrate, nucleic acid, and surfactant micelle systems; and end-user evaluation. Experimental protocols will be developed to allow a nonspeCialist to implement titration experiments with sound velocity as the observable.

Principal Investigator:

Sarvazyan, armen
0

Business Contact:


6093330710
Small Business Information at Submission:

Artan Laboratories
22 LANSDOWNE RD East Brunswick, NJ 08816

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No