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Hematopoietic Support by Adipose-Derived Stromal Cells

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
54100
Program Year/Program:
2001 / SBIR
Agency Tracking Number:
1R43HL069103-01
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ARTECEL SCIENCES, INC.
801 CAPITOLA DR, STE 8 DURHAM, NC 27713
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2001
Title: Hematopoietic Support by Adipose-Derived Stromal Cells
Agency: HHS
Contract: N/A
Award Amount: $100,000.00
 

Abstract:

Bone marrow transplantation requires large numbers of pluripotent hematopoietic stem cells to achieve a successful clinical outcome. Therefore, there is a pressing medical need for methods to expand stem cells ex vivo and accelerate their engraftment in vivo. These steps may be supported by cytokine-producing stromal cells. The scientists at Artecel Sciences have developed proprietary techniques to isolate and culture human stromal cells from adipose tissue that can be used for autologous and allogeneic transplantation. This SBIR investigates the hypotheses that adipose derived stromal cells will (1) support hematopoietic progenitor cell proliferation and differentiation in vitro and (2) accelerate their engraftment in vivo. Aim 1 (Phase I) will demonstrate that human adipose derived stromal cells will support proliferation of multipotent and pluripotent hematopoietic progenitors in short and long term cultures using flow cytometric and methylcellulose assays. This work provides a foundation for Phase H studies to determine: (Aim 3) The ability of ex vivo expanded hematopoietic progenitors to repopulate sublethally irradiated NOD/SCID mice; (Aim 4) The ability of adipose derived stromal cells to accelerate hematopoietic stem cell engraftment in sublethally irradiated NOD/SCID mice. PROPOSED COMMERCIAL APPLICATION: This SBIR will develop technology with application to all patients receiving bone marrow transplantation. Each year, 20,000+ patients under this therapy at an individual cost of $100,000. Artecel Sciences technology has the potential to significantly reduce the clinical and financial burden of these procedures.

Principal Investigator:

Jeffrey M. Gimble

Business Contact:


9194331100
CUNDERWOOD@ARTECEL.COM
Small Business Information at Submission:

ARTECEL SCIENCES, INC.
801 CAPITOLA DR, STE 8 DURHAM, NC 27713

EIN/Tax ID: 562217814
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No