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Cartilage Repair by Engineered Implant Feasibility study

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
66078
Program Year/Program:
2003 / SBIR
Agency Tracking Number:
AR048470
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Articular Engineering, LLC
1818 Skokie Blvd. Suite 158 Northbrook, IL 60062
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2003
Title: Cartilage Repair by Engineered Implant Feasibility study
Agency: HHS
Contract: 1R43AR048470-01A2
Award Amount: $100,000.00
 

Abstract:

DESCRIPTION (provided by applicant): This small business Innovation Research Phase I project proposes to define methodology to facilitate the growth of engineered cartilage tissue. Recent studies have demonstrated that the alginate recovered chondrocyte (ARC) method can be used to stimulate isolated adult articular chondrocytes in vitro to form viable cartilaginous tissue with good physiochemical properties. The purpose of this proposal is to define ARC culture conditions for the in vitro formation of pig cartilage tissue. ARC tissue produced in vitro will first be analyzed to determine the biochemical composition, histological appearance and functional properties. Then, the tissue will then be transplanted into full-thickness defects in articular cartilage of adult pigs. At a single time point after transplantation the biochemical composition, histological appearance and functional properties will again be assessed and related to a control defect and initial values. The data will be utilized to determine the feasibility of using the ARC method for the repair of injured or diseased cartilage tissue. Feasibility will be determined by pre-defined criteria related to the assessment of integration, maturation and functional properties after implantation. The proposed research will ideally lead to a commercial method of production of engineered tissue for surgical implantation to repair defects of articular cartilage in humans.

Principal Investigator:

Brian E. Pfister
8474989634
BPFISTER@ARTICULAR.COM

Business Contact:

Michael Hejna
8474989634
MHEJNA@ARTICULAR.COM
Small Business Information at Submission:

ARTICULAR ENGINEERING, LLC
ARTICULAR ENGINEERING, LLC 1818 SKOKIE BLVD, STE 158 NORTHBROOK, IL 60062

EIN/Tax ID: 364340910
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No