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DEVELOPMENT OF AN ENZYME IMMUNOASSAY FOR A MURINE CYTOKINE

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
16565
Program Year/Program:
1993 / SBIR
Agency Tracking Number:
16565
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Assay Research, Inc.
335 Paint Branch Drive College Park, MD 20742
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1993
Title: DEVELOPMENT OF AN ENZYME IMMUNOASSAY FOR A MURINE CYTOKINE
Agency: HHS
Contract: N/A
Award Amount: $500,000.00
 

Abstract:

UNDERSTANDING THE INTERACTIONS OF THE CYTOKINES OF THE IMMUNE SYSTEM IN THE REGULATION OF THE IMMUNE CASCADE DURING THE HOST- DEFENSE MECHANISM IS OF INTENSE SCIENTIFIC INTEREST (1-2). NEWLY EMERGING RESEARCH ALSO DEMONSTRATE THAT SOME OF THESE MOLECULES ACT IN AN ENDOCRINE FASHION OUTSIDE THE IMMUNE SYSTEM (3-8). EXAMINING THESE MOLECULES AS CIRCULATING ENDOCRINE COMMUNICATING SIGNALS OFFERS NEW SCIENTIFIC CHALLENGES, BUT THIS CHALLENGE HAS BEEN ESSENTIALLY THWARTED BY THE LACK OF SIMPLE, RELIABLE ASSAY SYSTEMS TO EVALUATE THESE MOLECULES IN BIOLOGIC FLUIDS OF EXPERIMENTAL ANIMALS. ALTHOUGH SOME ASSAYS EXIST FOR MONITORING HUMAN CYTOKINES, LITTLE OR NO ATTENTION HAS BEEN FOCUSED ON SUPPORTING BASIC CYTOKINE RESEARCH WITH ANALYTICAL SYSTEMS THAT EVALUATE MURINE CYTOKINES IN CULTURE MEDIA, AS WELL AS SERUM. THE SHORT-TERM GOAL IS TO DEVELOP AN ENZYME IMMUNOASSAY TO MEASURE THE MURINE CYTOKINE, INTERLEUKIN 6, HOWEVER, THE LONG-TERM GOAL IS TO DEVELOP A COMPLETE BATTERY OF MURINE CYTOKINE ENZYME IMMUNOASSAYS.

Principal Investigator:

Tamarkin, Lawrence
Principal Investigator
3014454220

Business Contact:

1 n43 dk12276-00
Small Business Information at Submission:

Assay Research, Inc.
335 Paint Branch Drive College Park, MD 20742

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No