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DEVELOPMENT OF AN ENZYME IMMUNOASSAY FOR A MURINE CYTOKINE
- Small Business Information
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Woman-Owned: NoMinority-Owned: NoHUBZone-Owned: No
- Phase 2
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Fiscal Year: 1993Title: DEVELOPMENT OF AN ENZYME IMMUNOASSAY FOR A MURINE CYTOKINEAgency: HHSContract: N/AAward Amount: $500,000.00
Abstract:
UNDERSTANDING THE INTERACTIONS OF THE CYTOKINES OF THE IMMUNE SYSTEM IN THE REGULATION OF THE IMMUNE CASCADE DURING THE HOST- DEFENSE MECHANISM IS OF INTENSE SCIENTIFIC INTEREST (1-2). NEWLY EMERGING RESEARCH ALSO DEMONSTRATE THAT SOME OF THESE MOLECULES ACT IN AN ENDOCRINE FASHION OUTSIDE THE IMMUNE SYSTEM (3-8). EXAMINING THESE MOLECULES AS CIRCULATING ENDOCRINE COMMUNICATING SIGNALS OFFERS NEW SCIENTIFIC CHALLENGES, BUT THIS CHALLENGE HAS BEEN ESSENTIALLY THWARTED BY THE LACK OF SIMPLE, RELIABLE ASSAY SYSTEMS TO EVALUATE THESE MOLECULES IN BIOLOGIC FLUIDS OF EXPERIMENTAL ANIMALS. ALTHOUGH SOME ASSAYS EXIST FOR MONITORING HUMAN CYTOKINES, LITTLE OR NO ATTENTION HAS BEEN FOCUSED ON SUPPORTING BASIC CYTOKINE RESEARCH WITH ANALYTICAL SYSTEMS THAT EVALUATE MURINE CYTOKINES IN CULTURE MEDIA, AS WELL AS SERUM. THE SHORT-TERM GOAL IS TO DEVELOP AN ENZYME IMMUNOASSAY TO MEASURE THE MURINE CYTOKINE, INTERLEUKIN 6, HOWEVER, THE LONG-TERM GOAL IS TO DEVELOP A COMPLETE BATTERY OF MURINE CYTOKINE ENZYME IMMUNOASSAYS.Small Business Information at Submission:Principal Investigator:
Tamarkin, Lawrence
Principal Investigator
3014454220Business Contact:
1 n43 dk12276-00Assay Research, Inc.
335 Paint Branch Drive College Park, MD 20742EIN/Tax ID:DUNS: N/ANumber of Employees: N/AWoman-Owned: NoMinority-Owned: NoHUBZone-Owned: No
Award Information
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Agency: Department of Health and Human Services |
Branch: N/A |
Award ID: 16565 |
Program Year/Program: 1993 / SBIR |
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Agency Tracking Number: 16565 |
Solicitation Year: N/A |
Solicitation Topic Code: N/A |
Solicitation Number: N/A |