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HAND-HELD DIAGNOSTIC FOR THE DETECTION OF AUTOANTIBODIES

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
19212
Program Year/Program:
1992 / SBIR
Agency Tracking Number:
19212
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Assay Research, Inc.
335 Paint Branch Drive College Park, MD 20742
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1992
Title: HAND-HELD DIAGNOSTIC FOR THE DETECTION OF AUTOANTIBODIES
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE DETECTION OF AUTOANTIBODIES IN THE LIVER DISEASES PBC, PSC AND CAH MAY SERVE AS A DIAGNOSTIC IN ASSESSING THE SEVERITY AND/OR PROGRESSION OF DISEASE. IN PHASE I WE PLAN TO DEVELOP ENZYME-BASED IMMUNOASSAYS (EIAS) FOR THE DETECTION OF AUTOANTIBODIES ASSOCIATED WITH PBC. WE PLAN TO USE THE RECOMBINANTLY ENGINEERED MOLECULE "PDC-E2/BCOADH-E2" WHICH CONTAINS THE ANTIGENIC DETERMINANATS FOR THE TWO CLASSES OF AUTOANATIBODIES ASSOCIATED WITH PBC AS THE DETECTION ANTIGEN. INITIALLY, WE WILL GENERATE A PLATE-BASED EIA OFFERING BOTH POSITIVE AND NEGATIVE CONTROLS FOR COMPARISON. UPON SUCCESSFUL COMPLETION OF THIS TASK, WE WILL, USING THE DESIGNER MOLECULE, DEVELOP A HAND-HELD DIAGNOSTIC FOR DETECTING THE AUTOANTIBODIES ASSOCIATED WITH PBC. THE HAND-HELD EIA, WILL BE A QUICK, SIMPLE SYSTEM WHICH COULD BE PERFORMED IN THE HOSPITAL AT THE PATIENT'S BEDSIDE OR IN A PHYSICIAN'S OFFICE. THE DATA FROM THE SUCCESSFUL COMPLETION OF THIS TASK WOULD THEN SERVE AS THE TECHNICAL BASE FOR THE DEVELOPMENT OF HAND-HELD EIAS FOR THE DETECTION OF AUTOANTIBODIES ASSOCIATED WITH PSC, AND CAH, AS WELL AS OTHER AUTOIMMUNE DISORDERS.

Principal Investigator:

Lawrence Tamarkin
3014454220

Business Contact:

Small Business Information at Submission:

Assay Research Inc
335 Paint Branch Drive College Park, MD 20742

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No