Alzheimer's disease (ad) is a devastating illness currently affecting over 2.5 million people in the united states, withfinancial costs for diagnosis and long-term care exceeding $50 billion annually. the etiology of ad is unknown, but its two biochemical hallmarks are the presence of extracellular… More

The objective of this research is to define antigens in the cerebrospinal fluid (csf) that are specific to alzheimer's disease. ultimately, the potential results of this effort may be the development of a csf-based diagnostic immunoassayfor use both as a diagnostic marker and as a useful adjunct to… More

The poor prognosis associated with brain neoplasms is a significant health problem in the united states. current chemotherapeutic approaches have been limited by the inability to achieve therapeutic concentrations in the brain. cyclophosphamide is unique among widely used chemotherapeutic agents in… More

The barrier to diffusion and transport of substances from the blood into the brain is denoted the blood-brain barrier. the blood-brain severely limits delivery to the brain of drugs that could be beneficial for treatment of central nervous systems (cns) diseases. current methods for testing drug… More

Alzheimer's disease is currently thought to affect as many as 1 to 3 million people in the united states alone. it hasrecently been found that the core a4 peptide of the senile person's plaque (one hallmark of the disease) is derived from a precursor protein 695 to 750 amino acids long. it is not… More