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RAPID ASSAY FOR HUMAN A(1)-PROTEINASE INHIBITOR DEFICIENCY

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
8078
Program Year/Program:
1989 / SBIR
Agency Tracking Number:
8078
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Athens Research And Technology
P O Box 5494 Athens, GA 30604
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1989
Title: RAPID ASSAY FOR HUMAN A(1)-PROTEINASE INHIBITOR DEFICIENCY
Agency: HHS
Contract: N/A
Award Amount: $500,000.00
 

Abstract:

THIS PROPOSAL INVOLVES THE DEVELOPMENT OF A SIMPLE ASSAY FORMEASURING FUNCTIONAL (1)-PROTEINASE INHIBITOR LEVELS IN HUMAN TISSUES. THE PROCEDURE UTILIZES THE FACT THAT INCUBATION OF EXCESS PORCINE PANCREATIC ELASTASE WITH EITHER PLASMA OR SERUM SAMPLES WILL RESULT IN COMPLEX FORMATION WITH FUNCTIONAL (1)-PROTEINASE INHIBITOR IN THESE FLUIDS. RESIDUAL ENZYME ACTIVITY CAN THEN BE CALCULATED AND A DETERMINATION MADE AS TO INHIBITOR LEVELS PRESENT IN THE ORIGINAL SAMPLE. THE TECHNIQUES TO BE UTILIZED SHOULD PROVIDE A RAPID AND RELIABLE PROCEDURE FOR THE EARLY SCREENING OF INDIVIDUALS WITH A GENETIC DEFICIENCY IN (1)-PROTEINASE INHIBITOR AND, THERBY, REDUCE THE RISK OF DEVELOPMENT OF FAMILIAL EMPHYSEMAIN THIS SEGMENT OF THE POPULATION.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Athens Research And Tech Inc.
Box 5494 Athens, GA 30604

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No