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Hematopoietic Reconstitution Using Ex Vivo Expanded Cord Blood CD34+ Cells

Company: ARTERIOCYTE, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: … this unmet medical need with rapid, high yield ex vivo expansion of UCB cells using our NANEXTM expansion platform. The NANEXTM platform is based on a nano-fiber scaffold that mimics the bone marrow stem cell niche and has been shown to expand UCB total nucleated cells (TNCs)… more

Advanced Processing and Cladding of High Density U-Mo Dispersion Fuels

Company: Powdermet Inc. Agency/Program/Year/Phase: DOE / SBIR / 2012 / 1
Abstract: … silicon, titanium nitride, and niobium, to the metallic fuels will be developed. A dedicated reactor will be designed and built, and silicon and niobium coatings will be applied to depleted uranium (or DU-Mo) powders to investigate differences in nucleation and growth… more

Novel Silicon Carbide Epitaxy Process for Dramatic Improvements to Material Characteristics, Cost, and Throughput

Company: SINMAT, INC. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1
Abstract: … power electronics applications. However, the manufacturing of reliable SiC power devices is a critical challenge because of the degradation of the forward current gain or voltage drop attributed to the propagation of Shockley-type stacking faults (SF) which are nucleated… more

Detecting Crack Nucleation/Damage Mechanisms In Sea-Based Aviation Environments

Company: Technical Data Analysis, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1
Abstract: TDA recognizes the need for analytical formulations for crack nucleation predictions and sensors to detect crack nucleation in environment assisted cracking of Naval aircraft structures. TDA proposes to investigate the role of microstructural damage evolution during pre-crack… more

The Use of Hydrogen for Defect Reduction in Large Format Infrared Detector Materials

Company: Amethyst Research Incorporated Agency/Program/Year/Phase: DOD / STTR / 2012 / 2
Abstract: … of this project is the elimination of active defects formed during molecular-beam epitaxy (MBE) of HgCdTe (the active layer in the arrays) on alternative substrates, i.e. materials other than lattice-matched CdZnTe. A significant fraction of as-grown defects nucleate at… more

Computational Fluid Dynamics (CFD) Tools for the Management of Bulk Residual Stress

Company: Airflow Sciences Corporation Agency/Program/Year/Phase: DOD / SBIR / 2012 / 2
Abstract: …, theoretical development, and validation. Small scale boiling experiments are suggested for improving the understanding of sub cooled oil boiling heat transfer. In particular, specific experiments are proposed for improving the understanding of nucleate site density… more

Detecting Crack Nucleation/Damage Mechanisms In Sea-Based Aviation Environments

Company: X-wave Innovations, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1
Abstract: To address the US Navy"s need for an innovative nondestructive evaluation (NDE) technique to detect the onset of crack nucleation in wet and dry corrosion environments under various stress fields and gradients. X-wave Innovations, Inc. (XII) along with Loyola University… more

Innovative System for Large Scale, Low Cost Production of High Quality Silicon Nanoparticles

Company: Physical Sciences inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1
Abstract: Physical Sciences Inc. proposes to apply its patented microwave driven jet (MIDJet) technology for low cost production of silicon nanopowders. The MIDJet will be used to form a narrow plasma jet from SiH4 gas and via supersonic expansion, nucleate/grow silicon nanopowders with… more

Non-Thermal Soot Denuder

Company: Aerodyne Research, Inc. Agency/Program/Year/Phase: NASA / SBIR / 2011 / 1
Abstract: We propose to develop a non-thermal soot denuder for measuring chemical components of the nucleation mode particulate matter emissions from gas turbine engines, in combination with an Aerodyne Aerosol Mass Spectrometer (AMS). This proposed approach will effectively eliminate the… more

Laser In-Situ Diagnostics and Processing Probes for Electron Microscopes

Company: AppliFlex LLC Agency/Program/Year/Phase: DOE / SBIR / 2011 / 2
Abstract: … the materials and biological sciences and in particular for the development of nanotechnology to answer the growing needs to protect our environment, increase energy efficiency and develop clean energy sources. Achieving a fundamental understanding of materials nucleation and… more

Mobile Ice Nucleus Counter

Company: Droplet Measurement Technologies Agency/Program/Year/Phase: DOE / STTR / 2011 / 2
Abstract: Ice crystals can form spontaneously from the freezing of water droplets at temperatures colder than -38C - homogeneous nucleation - or from multiple processes termed heterogeneous nucleation that occur on refractory/insoluble substances at warmer temperatures… more

Non-invasive Aneuploidy Screening of Circulating Fetal Cells for Prenatal Diagnos

Company: GENE SECURITY NETWORK Agency/Program/Year/Phase: HHS / SBIR / 2011 / 2
Abstract: … trimester chorionic villus sampling (CVS) and second trimester amniocentesis are relatively safe, both procedures are not without negligible risks. In efforts to avoid these risks altogether, researchers have turned toward isolating circulating fetal nucleated red blood… more

A Novel, Inexpensive Cryopreservation System for Stable -80 degree C Storage of A

Company: GENERAL BIOTECHNOLOGY, LLC Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: … solution with cryoprotectants (CPAs) that is thermodynamically stable at temperatures as high as -80oC, so that the cryopreserved samples can be stored and shipped using conventional -80oC freezers and dry ice, respectively. An inexpensive, easy-to-use, self-nucleating… more

Novel Very Large Scintillator Crystal Growth Method

Company: Nanotrons Corp. Agency/Program/Year/Phase: DHS / SBIR / 2011 / 1
Abstract: … single crystal ingots by continuous solidification from a seed crystal without any moving parts. Due to the simplicity, the proposed process has salient advantages of large size and low cost. Without movements, the new process also prevents secondary nucleation and ensuring… more

Inkjet Based System for Lipid Cubic Phase Crystal Screening of GPCR's

Company: MicroFab Technologies Inc Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: … and precipitant via inkjet dispensing, creating a novel methodology for these existing technologies. The in meso LCP creates an organizing and stabilizing environment in which the protein retains its native conformation and activity, thus better facilitating nucleation and… more

Flowcell for Biological Imaging with LiquidSTEM

Company: PROTOCHIPS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2011 / 2
Abstract: …wil study the structural differences of a selection of mutants of live S. pombe yeast cells with liquid STEM. We will study the physical and chemical controls that organic matrices such as collagen and amelogenin play in directing the early stages of calcium phosphate nucleation… more

High Temperature Resistant Zirconia Coating for In-space Propulsion

Company: Spire Corporation Agency/Program/Year/Phase: NASA / SBIR / 2011 / 1
Abstract: … inadequately adhere, and often spall. The proposed coating will distribute stress induced by thermal cycling and improve adhesion, resulting in an improved and longer lasting coating. The high temperature phase of ZrO2 is produced by controlling nucleation, grain… more

Melt Extrudable Nanocomposite Liquid Crystal Polymer Films

Company: Systems and Materials Research Corporation Agency/Program/Year/Phase: DOD / SBIR / 2011 / 1
Abstract: …to increase the barrier and tensile properties in a variety of systems. The nanoclay plates act as non-melting smectic regions that are aligned with shear. These nanomaterials have also been found to increase the rate of crystallization of LCP by acting as nucleation sites. We… more

SBIR Phase I: Acoustic Slurry Monitor

Company: Uncopiers, Inc. Agency/Program/Year/Phase: NSF / SBIR / 2011 / 1
Abstract: … of wafers at all stages of IC manufacture. This acoustic slurry monitor makes use of a novel technology?Acoustic Coaxing Induced Microcavitation (ACIM), a means of constructively controlling acoustic microcavitation. It does so by facilitating controlled bubble nucleation… more

Corrosion Resistant Naval Alloys: Innovative Multi-Scale Computational Modeling and Simulation Tools

Company: VEXTEC Corporation Agency/Program/Year/Phase: DOD / SBIR / 2011 / 2
Abstract: … fleet of the future. The corrosion process is complex involving a combination of factors including material chemistry, processing history, microstructure, and operational environment. During the Phase I, VEXTEC demonstrated physics based corrosion pit nucleation model… more

Innovative Molecular Platform for Prenatal Diagnostics

Company: GigaGen Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: …, synthesis, and sequence capture. Third, we propose to use these optimized to synthesize a 200,000-plex probe pool specifically for prenatal diagnostics. Finally, we will validate the molecular technology on archival genomic DNA, amniotic fluid, and fetal nucleated red blood… more

Protein Therapeutics for Muscular Dystrophy

Company: TRIM-EDICINE, INC. Agency/Program/Year/Phase: HHS / SBIR / 2010 / 1
Abstract: … by the lack of knowledge of the molecular components involved. Recent studies show that Mitsuguimin 53 (MG53), a muscle-specific TRIM-family protein (TRIM72), is an essential component of the acute membrane repair machinery. MG53 acts as a sensor of oxidation to nucleate… more

SBIR Phase I: Replacement of Toxic and Polluting Cleaning Processes Using Vacuum Cycle Nucleation

Company: METFAB Agency/Program/Year/Phase: NSF / SBIR / 2010 / 1
Abstract: This Small Business Innovation Research (SBIR) Phase I project will develop a vacuum-based cleaning process that relies on the tendency of vapor bubbles to form at surface crevices where contaminate particles lodge. Upon implosion, the bubbles release a large amount of localized energy meant to… more

Fatigue Life Modeling & Simulation of Elastomer-Polymer Materials

Company: Endurica LLC Agency/Program/Year/Phase: DOD / SBIR / 2010 / 1
Abstract: … its underlying principles and operability. The tasks will be developed around the following main themes: 1) material model definition, 2) analysis of the multiaxial, variable amplitude duty cycle occurring at a single material point, and 3) simulation of crack … more

SBIR Phase I:Two-Phase Microchannel Heat Sink with Porous Layers Lining Channel Inner Walls

Company: Advanced Cooling Technologies, Inc. Agency/Program/Year/Phase: NSF / SBIR / 2010 / 1
Abstract: …nnel heat sinks by addressing two key issues: parallel channel instabilities and transient dryout of channels experiencing vapor explosion. The specific feature in the proposed concept is a porous layer lining the heat sink walls. The porous layer provides more uniform … more