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Oral vaccine delivery of recombinant subunit vaccines for animal diseases

Company: VST LLC dba Medgene Labs Agency/Program/Year/Phase: DHS / SBIR / 2014 / 1
Abstract: Wildlife are a reservoir of diseases affecting both humans and domestic animals. These wildlife reservoirs represent a potential threat to public health, serving as a continuous and difficult to eradicate source of infection for zoonotic diseases, but may also represent a significant economic threat… more

Rock Melt Borehole Sealing System

Company: RE/SPEC Inc. Agency/Program/Year/Phase: DOE / SBIR / 2014 / 1
Abstract: Deep geological disposal is a promising and widely accepted method for long- term disposal of nuclear waste and the option of deep borehole disposal is considered an inherently safe method. The feasibility of the deep borehole option relies upon the design and construction of an effective seal… more

SBIR Phase II: A Microbially-Based Process to Produce a High-Quality Soy Protein Concentrate for Complete Fish-Meal Replacement in Aquaculture Diets

Company: DAST, LLC Agency/Program/Year/Phase: NSF / SBIR / 2013 / 2
Abstract: This Small Business Innovation Research (SBIR) Phase I project will develop a process to produce high quality soy protein concentrate (HQSPC) as a fish meal replacer in aquaculture feeds, while providing a binding agent for extrusion and an immunoprophylactic for disease control. Increased demand… more

SBIR Phase I: Low-cost highly-reflective and light scattering dielectric nanoparticle based thin films for solar cells

Company: DSST, LLC Agency/Program/Year/Phase: NSF / SBIR / 2013 / 1
Abstract: This Small Business Innovation Research Phase I project aims to demonstrate the feasibility of an innovative concept in using highly reflective and light scattering nanoparticle thin films as solar cell back reflectors with the goal to replace high-vacuum processing techniques. Conventional back… more

PV Module. Title: Optimal Multijunction Solar Cells for CPV under Realistic Conditions.

Company: Black Hills Nanosystems Corporation Agency/Program/Year/Phase: DOE / SBIR / 2013 / 1
Abstract: The proposed DoE STTR project will provide a pathway for terrestrial CPV (500 to 700 Suns) multi- junction solar cells that will maintain extremely high efficiencies at realistic operating temperatures. The thrust of the proposed project will adapt an integration approach from MEMS to III-V… more

Low-Cost Multi-Junction Photovoltaic Cells

Company: Black Hills Nanosystems Corporation Agency/Program/Year/Phase: NASA / SBIR / 2013 / 1
Abstract: The proposed SBIR project will provide a pathway to dramatically reduce the cost of multi-junction solar cells. The project leverages a TRL6 micropackaging process with ~100% yield for cell assembly. Cost savings are critical as space-qualified multi-junction cells render large panel applications… more

Label-free platform for applications in drug discovery

Company: MEDGENE LABS Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): The primary sequelae resulting from radical mastectomy and sentinel lymph node removal during the treatment of breast cancer is the development of lymphedema in related limbs. Estimates of the frequency of post-cancer lymphedema range from 20%-90%, depending upon… more

Development and Scale-Up of Nanothermite Composites for Propellant Ignition

Company: INNOVATIVE MATERIALS & PROCESSES, LLC Agency/Program/Year/Phase: DOD / SBIR / 2012 / 2
Abstract: The main objective of this proposal SBIR Phase II project is to scale-up and demonstrate the low-cost formation of 15-35 kg/yr of nanothermite-nitrocellulose composite granules for propellant ignition and as additives to explosive materials. All of the reactants used for the energetic composites… more

Production of high protein distillersâ dried grains with solubles (HP-DDGS) to replace fish meal in aquaculture diets.

Company: DAST, LLC Agency/Program/Year/Phase: USDA / SBIR / 2012 / 1
Abstract: In 2007, wild captured fish accounted for about 15.7% of the animal protein consumed by humans on a global basis, and per capita consumption of fish and shellfish products is increasing, parallel with the global human population. Unfortunately, harvest rates of wild fish have decreased by ~0.7 mmt… more

Engineering Photosynthetic Cyanobacteria to Produce the Energy-Dense Fuel Farnesene from Carbon Dioxide

Company: DAST, LLC Agency/Program/Year/Phase: USDA / SBIR / 2012 / 1
Abstract: The goal of the project is to genetically engineer photosynthetic cyanobacteria that will synthesize farnesene from carbon dioxide. The work will then involve shutting down pathways that compete for carbon in an attempt to maximize the amount of farnesene that can be produced. Then we will do… more

SBIR Phase I: A microbially-based process to produce a high-quality soy protein concentrate for complete fish-meal replacement in aquaculture diets

Company: DAST, LLC Agency/Program/Year/Phase: NSF / SBIR / 2012 / 1
Abstract: This Small Business Innovation Research (SBIR) Phase I project will develop a process to produce high quality soy protein concentrate (HQSPC) as a fish meal replacement in aquaculture feeds, while providing a binding agent for extrusion and an immunostimulant for disease control. The proposed… more

SBIR Phase I: Efficient and Scalable Production of Functionalized Electrospun Nanofiber Felts of Regenerated Cellulose with Superior Capacity and Throughput for Bioseparations

Company: Nanofiber Separations, LLC Agency/Program/Year/Phase: NSF / SBIR / 2012 / 1
Abstract: This Small Business Innovation Research (SBIR) Phase I project from Nanofiber Separations, LLC will establish an innovative type of bioseparation media utilizing electrospun nanofiber felts of regenerated cellulose with high specific surface area as the support for protein adsorption ligands.… more

SBIR Phase II: On-Farm Algae Production for Livestock Feed and Biofuel

Company: SARC Intl Agency/Program/Year/Phase: NSF / SBIR / 2011 / 2
Abstract: This Small Business Innovation Research (SBIR) Phase II project plans to refine and test prototype facilities for commercialization of on-farm algae production and harvesting. Algae will be utilized initially for livestock feed and in future for bio-fuel. The project targets an emerging global… more

Development of a simple killed enterotoxigenic E. coli vaccine for weaned pigs

Company: BROOKINGS BIOMEDICAL Agency/Program/Year/Phase: USDA / SBIR / 2011 / 1
Abstract: Enterotoxigenic Escherictia coli causes diarrhea (E. coli scours) in young weaned pigs. There currently are no licensed killed vaccines for the disease, and the available living vaccines do not express toxins which should be a major target of a vaccine. This lack of toxin antigens may affect how… more

FORMULATION AND PRODUCTION OF NOVEL BARRIER MATERIALS

Company: DAKOTA ANALYTICAL SOLUTIONS Agency/Program/Year/Phase: DOD / SBIR / 2011 / 1
Abstract: Development and production of materials to serve as quality control standards during evaluation of candidate materials for IPE and ColPro Acquisition Programs will be accomplished utilizing advanced nanocomposite technology. In our process, polymeric membranes serve as the building blocks for the… more

Development and Scale-Up of Nanothermite Composites for Propellant Ignition

Company: INNOVATIVE MATERIALS & PROCESSES, LLC Agency/Program/Year/Phase: DOD / SBIR / 2011 / 1
Abstract: This SBIR Phase I project proposes development of a technologically feasible batch process for making nitrocellulose-nanothermite composites in a granular form for the ignition of propellants. The R & D will focus on the determination of burn rates, dynamic pressure profiles and ESD… more

SBIR Phase I: Scale-up of a Butanol and Hydrogen Production System

Company: Genetic Architecture Education Analysis (GAEA), Inc. Agency/Program/Year/Phase: NSF / SBIR / 2011 / 1
Abstract: This Small Business Innovation Research (SBIR) Phase I project will develop a costeffective butanol production and purification process. The specific aim of this project is to scaleup a butanol production system from a small, ?laboratory scale? ,2 liter volume, to a 200 liter culture volume in order… more

SBIR Phase I: On-Farm Algae Production for Livestock Feed

Company: SARC Intl Agency/Program/Year/Phase: NSF / SBIR / 2010 / 1
Abstract: This SBIR Phase I project will study novel algal strains to produce large amounts of high quality animal feed using on-farm resources including spare heat, flue gas, and livestock manure. Research will focus on algal growth under cool climate and low sun conditions to achieve reliable year-round… more

Multivalent Mucosal Vaccine to Include Swine Influenza

Company: BROOKINGS BIOMEDICAL Agency/Program/Year/Phase: USDA / SBIR / 2010 / 1
Abstract: We have established that E. coli heat labile enterotoxin (LT) is an excellent mucosal adjuvant (immune enhancer) for stimulating immunity in young pigs and does not cause diarrhea or other adverse reactions when administered by intranasal inoculation, even at a relatively high dosage.… more

Integrated Information Security Management System for Rural Small & Medium Sized Entities (rSME-IISMS)

Company: Secure Banking Solutions Agency/Program/Year/Phase: USDA / SBIR / 2010 / 1
Abstract: Computers have become ubiquitous and store huge amounts of sensitive data. An article in InformationWeek highlighted the problem: "More electronic records were exposed in 2008 than in the previous four years combined and most of those breaches -- nine out of 10 -- could have been easily avoided with… more

Antibacterial, antifungal, antiviral, and antispore paints

Company: Prairie Scientific Innovations Agency/Program/Year/Phase: HHS / STTR / 2010 / 1
Abstract: DESCRIPTION (provided by applicant): There is a fast growing need for antimicrobial paints and coatings to improve microbial quality in residential, commercial, institutional, and industrial applications so as to control the growth of mold and/or reduce the risk of healthcare-associated infections… more

SBIR Phase I: Information Risk Management System for Small and Medium-Sized Financial Institutions

Company: Secure Banking Solutions Agency/Program/Year/Phase: NSF / SBIR / 2009 / 1
Abstract: This Small Business Innovative Research (SBIR) Phase I project will develop a tool to assist small and medium-sized financial institutions (SMFI) to understand their information risk and what they should do about it. This project will test the feasibility of pre-defining information security threats… more

Low-Cost Processing of Aluminum-Based Nanothermites

Company: INNOVATIVE MATERIALS & PROCESSES, LLC Agency/Program/Year/Phase: DOD / SBIR / 2009 / 2
Abstract: Innovative Materials and Processes, LLC proposes to develop and demonstrate a high throughput mixing/metering.drying system to enable i) scale-up water-based production of Al-Bi2O3 superhtermite and ii) assembly of medium caliber electric primers using this superthermite material. The R&D project… more

Sensitive ImmunoPCR of Blood-Borne Prions

Company: RURAL TECHNOLOGIES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2009 / 1
Abstract: DESCRIPTION (provided by applicant): Transmissible Spongiform Encephalopathies are a family of progressive, invariably fatal neurological disorders. Unlike more conventional infectious diseases, TSEs appear to be caused by a new family of infectious agents , a misfolded self protein (PrPd) capable… more

Adaptation of Inquiry-Based Learning Modules for Health Science Literacy

Company: SOUTH DAKOTA HLTH TECH INNOVATIONS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2009 / 2
Abstract: DESCRIPTION (provided by applicant): Creature Control: Food for Thought is a health science curriculum supplement and obesity prevention unit tailored to be effective with American Indian (AI) students. It considers the AI experience as its frame of refere nce and much of the visual representation… more