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TOPIC 277 PHASE II; COMPANION DIAG: PREDICTIVE AND PROGNOSTIC TEST ENABLING PERSO

Company: INSIGHT GENETICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2013 / 2
Abstract: Not Available

Quantitative Methods for Reliability and Fault Tolerance Testing of Digital Instrumentation and Control

Company: Analysis And Measurement Services Corporation Agency/Program/Year/Phase: DOE / SBIR / 2013 / 1
Abstract: Obsolescence, aging, reliability, and performance issues are driving nuclear facilities to replace conventional analog I & amp;C systems with digital technologies. The increased complexity of digital systems, compared to their analog counterparts, has resulted in faults that are often more… more

Condition Monitoring of Live Cables in Nuclear Power Plants

Company: Analysis And Measurement Services Corporation Agency/Program/Year/Phase: DOE / SBIR / 2013 / 1
Abstract: No method currently exists for detecting intermittent faults in nuclear power plant cable circuits, which include circuit components, connectors, and end devices. Conventional techniques can locate hard faults, such as open or short circuits, but not the intermittent faults that occur … more

Development of an In-Situ Method for Cable Condition Monitoring in Nuclear Power Plants

Company: Analysis And Measurement Services Corporation Agency/Program/Year/Phase: DOE / SBIR / 2013 / 1
Abstract: In the U.S., almost all the 104 operating commercial nuclear power plants have applied or plan to apply for license renewal, many of which have recently received approval. This has given rise to questions about the aging of structures, systems, and components (SSCs) that are important to plant… more

Online Monitoring in Small Modular Reactors

Company: Analysis And Measurement Services Corporation Agency/Program/Year/Phase: DOE / STTR / 2013 / 2
Abstract: Small Modular Reactors (SMRs) are one of the most compelling options for meeting the growing clean energy demands of the U.S. While safer and costing less to build and operate than their conventional counterparts, the unique requirements of SMRs pose significant challenges to the maintenance of… more

Advanced Diagnostics for the Control Element Drive Mechanism System in Pressurized Water Reactors

Company: Analysis And Measurement Services Corporation Agency/Program/Year/Phase: DOE / SBIR / 2013 / 2
Abstract: A light water reactor is equipped with control and shutdown rods which are inserted into and withdrawn from the reactor core to control reactivity. The positioning of the control and shutdown rods is performed in Combustion Engineering designed plants with the control element drive mechanism… more

PictureRx: Improving Medication Safety in Health Disparity Populations

Company: SAI INTERACTIVE, INC. Agency/Program/Year/Phase: HHS / SBIR / 2013 / 2
Abstract: Abstract Medication safety is an important concern in hospital Emergency Departments (EDs), which provide approximately 136 million patient visits annually in the US and are a common site of care for health disparity populations. In more than one-third ofED visits, patients are unable to provide an… more

Reliable Actuator for Cryo Propellant Fluid Control

Company: Dynamic Structures and Materials, LLC Agency/Program/Year/Phase: NASA / SBIR / 2013 / 2
Abstract: Fluid handling applications in cryogenic and extreme environments require reliable actuation technology that can handle extreme temperatures, mechanical bind-up from ice and foreign contaminants, and operation in poor conditions. A novel EM hammer drive technology is proposed for use in… more

High Flow, Extended-Wear Respirators for Ambient Particulate Matter Protection

Company: eSpin Technologies, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2013 / 1
Abstract: This SBIR Phase I proposal proposes to design, develop, and produce high performance air filter media with low pressure drop and longer life for dust mask application. Non-woven composite filter media with macro and nanofiber will be produced to obtain design specifications. Fiber size, packing… more

Augmentor Stability

Company: Gloyer-Taylor Laboratories LLC Agency/Program/Year/Phase: DOD / SBIR / 2013 / 1
Abstract: ABSTRACT: As with all other combustion devices, the augmentors in high-performance gas turbine engines are at risk of combustion instability. While it is tempting to apply brute force CFD to address this problem, at best high fidelity CFD may reveal what happens but not why it happens. While… more

High Pressure Breathing System

Company: Gloyer-Taylor Laboratories LLC Agency/Program/Year/Phase: DOD / SBIR / 2013 / 1
Abstract: GTL proposes to develop a small diameter High Pressure Breathing Apparatus concept design capable of achieving 10,000-psi operating pressures. The HPBA incorporates a high-pressure regulator and valve that makes it compatible and component replaceable with existing conventional SCUBA and SCBA… more

Automated Identification and Sorting of Rare Earth Elements in an E-Waste Recycling Stream

Company: National Recovery Technologies LLC Agency/Program/Year/Phase: EPA / SBIR / 2013 / 1
Abstract: Electronic waste (e-waste) is one of the most rapidly growing waste problems worldwide. Improper handling of e-waste results in vast amounts of toxic waste being sent to landfill and leaching into the water supply. Due to these concerns e-waste recycling is a rapidly growing industry. … more

Modular Planar Germanium Detector Systems for High Resolution Gamma-ray Spectroscopy and Tracking Arrays

Company: Phds Co. Agency/Program/Year/Phase: DOE / SBIR / 2013 / 1
Abstract: The Department of Energy (DOE) Office of Nuclear Physics maintains gamma-ray detector arrays as user facilities. The Modular Planar Germanium (MPGe) detector systems to be developed here will provide a lower cost, higher resolution, basis for such detector arrays. The MPGe detector systems will be… more

Game-Based Deployable Trainer with True 3D and High Acuity Display

Company: Third Dimension Technologies Agency/Program/Year/Phase: DOD / SBIR / 2013 / 1
Abstract: ABSTRACT: To address Air Force"s need for high fidelity training and rehearsal environments in next-generation multirole aircraft, Third Dimension Technologies (TDT) proposes to develop a new low-cost Warfighter 3D Gaming Environment (W3DGE). The W3DGE is a game-based, networked,… more

Development of Multidisciplinary, Multi-Fidelity Analysis and Integration of Aerospace Vehicles

Company: VEXTEC Corporation Agency/Program/Year/Phase: DOD / SBIR / 2013 / 2
Abstract: ABSTRACT: The Phase II objective is to develop a probabilistic multi-disciplinary, multi-fidelity uncertainty management analytical tool that links aerodynamic analysis, structural analysis, and fatigue analysis to predict the durability for airframe components and demonstrate that the tool can be… more

Development of an Atmospheric Plasma Applicator to Treat Chronic Wounds

Company: ADVANCED PLASMA PRODUCTS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2013 / 2
Abstract: DESCRIPTION (provided by applicant): Annually, 5 to 7 million Americans are treated for chronic wounds that arise from diabetes, lower extremity arterial disease, lower extremity venous disease, pressure ulcers, and traumatic injuries, including burns, demonstrating the need for new advanced… more

An Advanced Biosensor for Molecular Interaction Studies.

Company: MOLECULAR SENSING, INC. Agency/Program/Year/Phase: HHS / STTR / 2013 / 2
Abstract: DESCRIPTION (provided by applicant): Molecular interactions form the foundation of biology and chemistry. They are central to life itself and determine catalytic activity, cellular function, and therapeutic efficacy. The vast majority of diagnostic procedures depend on some type of specific… more

Expressing bacterial bioluminescence in human cell lines: Engineering autobiolumi

Company: 490 BIOTECH, INC. Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): Expressing bacterial bioluminescence in human cell lines: Engineering autobioluminescent reporter cells to screen for endocrine disruptor chemicals Project Summary This Small Business Innovation Research Phase I projectproposes to engineer an autobioluminescent… more

Biosensor and Controller for Closed Loop Anesthesia Delivery System

Company: Infusense Agency/Program/Year/Phase: DOD / SBIR / 2013 / 1
Abstract: Microfabricated chemical and biological sensors serve as an interface between biologic and electronic systems. Previously, through TATRC-funded research grants (W81XWH-05-2-0064, W81XWH-10-1-0358), we have investigated the behavior and detection of propofol using electrochemical (EC) methods. Using… more

OTHER FUNCTIONS DEVELOPMENT OF A COMPANION DIAGNOSTIC FOR ALK MUTATIONS.

Company: INSIGHT GENETICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2
Abstract: Constitutively activated forms of ALK caused by genetic aberrations have been shown to cause an expanding variety of human cancers. The FDA recently approved the Pfizer drug Xalkori (crizotinib) to treat patients with non-small cell lung cancers (NSCLC) that express ALK. Numerous other… more

IGF::OT::IGF OTHER FUNCTIONS - RandD BIOMEDICAL (BASIC RESEARCH)

Company: INSIGHT GENETICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: Lung cancer is the main cause of cancer mortality worldwide with 80% non-small cell lung cancer (NSCLC) in type and mainly driven by three mutually exclusive oncogenes, EGFR, KRAS and ALK (collectively between 30-60% of all NSCLC cases). Oncogenic driverssuch as ROS1 and RET fusions and DEPDC1… more

Electromagnetic Pulse Effects Simulator

Company: Accurate Automation Corporation Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1
Abstract: Utilizing directed energy weapons effectively in an offensive situation or determining the level of protection needed for defense requires the ability to select the proper DEW source characteristics and method of delivery based on the target, any shielding and the desired effect. This is an… more

Repeatable Virtualization of Intelligence, Surveillance&Reconnaissance (ISR) System Servers

Company: Accurate Automation Corporation Agency/Program/Year/Phase: DOD / SBIR / 2012 / 2
Abstract: Accurate Automation Corporation proposes an innovative application of virtualization tools to complex information systems, especially the Joint Multi-mission Protection System (JUMPS). The program includes three parts. 1. A plan will be developed and implemented to facilitate the operation and to… more

Direct Optical Modulation of HVDC on an RF Transmission Line

Company: Accurate Automation Corporation Agency/Program/Year/Phase: DOD / SBIR / 2012 / 2
Abstract: Accurate Automation Corporation proposes to develop a system for a self-contained missile launchable RF Generator based on a frozen wave transmission line technique. The RF transmission line will be charged through an optically activated switch fabricated from silicon carbide. A high energy pulsed… more

Rod Control System On-Line Condition Monitoring and Advanced Diagnostics for Existing and Next Generation Nuclear Power Plants

Company: Analysis And Measurement Services Corporation Agency/Program/Year/Phase: DOE / SBIR / 2012 / 2
Abstract: Aging and obsolescence issues have recently led to problems with the rod control systems of existing pressurized water reactors. These issues, along with plans for plant life extension, have prompted the industry to actively seek viable options to monitor the health of these systems in order to… more