High-Power, Continuous-Wave 3.0- to 3.5-Micron Emitting Quantum Cascade Semiconductor Laser
Company: Intraband LLC Agency/Program/Year/Phase: DOD / STTR / 2012 / 1Abstract: The technical objectives of this proposal are: 1) the design of 3.0-3.5 micron-emitting quantum cascade laser (QCL) structures grown on metamorphic-buffer-layer (MBL) substrates; 2) the realization of electroluminescent QCL structures on MBLs with emission in the 3.0-3.5-micron wavelength range.… more
On-Chip Passive Phase-Locking for High Coherent Power, Mid-IR Quantum Cascade Lasers
Company: Intraband LLC Agency/Program/Year/Phase: DOD / STTR / 2012 / 2Abstract: The technical objectives of this proposal are: 1) Implement the design developed in Phase I for the realization of 8 micron-emitting active-photonic-crystal (APC) quantum-cascade (QC) lasers of 3 W average, diffraction-limited power and 15 % wallplug efficiency in quasi-CW operation; 2) Design and… more
iCivics+: Games and Games-Based Assessments to Prepare Students for Better Citizenship
Company: Filament Games Agency/Program/Year/Phase: ED / SBIR / 2012 / 1Abstract: Democracy relies on informed and active participation of citizens. This project team is developing a prototype of a formative assessment component to be added to the GoCivics games, a tablet-based intervention through which middle school students engage in compelling learning activities and… more
Go-Civics Mock Trial
Company: Filament Games Agency/Program/Year/Phase: ED / SBIR / 2012 / 1Abstract: Studies show that many American students do not possess basic knowledge of the America judicial branch of government, one of three pillars upon which democracy rests. This project team is developing a prototype of the GoCivics Mock Trial, a multiplayer, augmented reality, role-playing game for use… more
SBIR Phase II: Game-enhanced Interactive Physical Science
Company: Filament Games Agency/Program/Year/Phase: NSF / SBIR / 2012 / 2Abstract: This Small Business Innovation Research (SBIR) Phase II project will produce a set of engaging educational video games and associated teaching compendiums for middle school physical science classrooms that are optimized for students with diverse sets of learning needs, including those with learning… more
SBIR Phase II: Targeted Production of Spider Silk Fibroins in Plant Trichomes
Company: PhylloTech Agency/Program/Year/Phase: NSF / SBIR / 2012 / 2Abstract: This Small Business Innovation Research (SBIR) Phase II project proposes to develop a platform for the production of spider silk fibroins in plant trichomes. Synthetic spider silk has great potential as an environmentally-friendly biomaterial because it is very flexible yet has a tensile strength… more
Phytoextraction of Cadmium from Plant Trichomes Expressing a Stabilized Antibody
Company: PhylloTech Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I project will investigate the feasibility of utilizing a stabilized, cadmium-binding antibody to sequester cadmium in plant trichomes. Heavy metals such as cadmium are ubiquitous contaminants in soil surrounding… more
STTR Phase II: Using Nanoparticle Oxide Coatings to Extend Cycle Life of Cathode Materials in Lithium-Ion Batteries
Company: SolRayo Agency/Program/Year/Phase: NSF / STTR / 2012 / 2Abstract: This Small Business Innovation Research (SBIR) Phase II project seeks to increase the cycle life of cathode materials used in lithium-ion batteries by a factor of ten in high-temperature applications by applying protective nanoporous ceramic coatings. SolRayo will investigate the effects that… more
Screening Device for Differentiated Primary Cell Models of Airway Epithelia
Company: BELLBROOK LABS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2Abstract: DESCRIPTION (provided by applicant): Approaches to drug screening typically involve dramatic compromises in order to achieve high throughput and hold down costs. Examples include the use of immortalized, heterologous cell lines, and genetic engineering toover-express the target protein and/or… more
Identification of Biomarkers of Cardiotoxicity using Metabolomics of Human Plurip
Company: Stemina Biomarker Discovery, inc. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): Cardiotoxicity, as a result of adverse drug effects, is a serious problem that has yet to be effectively screened prior to patient exposure. Cardiac safety is one of the leading causes of compound attrition in the pharmaceutical industry and withdrawal of… more
SBIR Phase II: De novo assays for detection of the proteolytic activity in botulinum neurotoxin-based pharmaceuticals
Company: BIOSENTINEL, LLC Agency/Program/Year/Phase: NSF / SBIR / 2012 / 2Abstract: This Small Business Innovation Research (SBIR) Phase II project proposes to complete development of a universal, in vitro assay for determining the enzymatic activity of botulinum neurotoxin (BoNT)-based pharmaceuticals. This assay, called BoTest Matrix A Assay, will enable standardized comparisons… more
Comparison of agricultural marketing success across multiple platforms
Company: Hevva LLC Agency/Program/Year/Phase: USDA / SBIR / 2012 / 1Abstract: Each week, in total, 338 small and mid-sized farms ($1,000-500,000 in revenue) go out of business despite the undeniable demand for local food. This proposal will work with a state department of agriculture to research the viability of real-time price sheet marketing, as compared to static… more
Automated Interactive Text Messaging to Assess Adolescent Depression
Company: CENTER FOR PSYCHOLOGICAL CONSULTATION Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2Abstract: DESCRIPTION (provided by applicant): The internet is an increasingly important resource for clinicians to access training materials and resources for treatment delivery of evidence-based treatments such as cognitive behavioral therapy (CBT) and antidepressant medications. This project proposes to… more
Speech-based biomarkers of CNS dysfunction associated with early Alzheimers disea
Company: CENTER FOR PSYCHOLOGICAL CONSULTATION Agency/Program/Year/Phase: HHS / STTR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): More efficient methods to screen and monitor elderly patients in clinical practice and research are needed, but visits to clinical offices are expensive and many older patient are restricted by mobility or transportation access. The Alzheimer's Disease… more
Automating MRI Delta T1 Methods for the Routine Assessment of Brain Tumor Burden
Company: IMAGING BIOMETRICS, LLC Agency/Program/Year/Phase: HHS / STTR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): Contrast enhancement on MRI (magnetic resonance imaging) provides the best currently available approach for measuring tumor response to therapy in brain and other solid tumors. Accordingly, criteria have been formulated, by international committees, to guide the… more
Modeling Professional Attitudes and Teaching Humanistic Communication in VR
Company: MEDICAL CYBERWORLDS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2Abstract: DESCRIPTION (provided by applicant): Modeling Professional Attitudes and Teaching Humanistic Communication in VR (MPathic-VR) Patients with life-threatening cancer need caregivers who can help them through difficult decisions by understanding their interests, values, and beliefs, and who… more
Point of Care Detection of Respiratory Viruses
Company: LUCIGEN CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2Abstract: DESCRIPTION (provided by applicant): Respiratory infections have a significant health and economic impact worldwide. Current test products for the diagnosis of respiratory viral infections such as influenza are inadequate for the timely diagnosis needed for successful implementation of antiviral… more
Random Shear Shuttle BAC Libraries for Antimicrobial Discovery from Soil Metageno
Company: LUCIGEN CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2Abstract: DESCRIPTION (provided by applicant): 100,000 Americans perish each year due to untreatable bacterial infections. The societal benefits of new antibiotic compounds that are effective against numerous multiple drug resistant pathogens would be significant. The best possible source for new antibiotic… more
NOVEL SOLUBILITY-ENHANCING PROTEIN EXPRESSION TECHNOLOGY
Company: LUCIGEN CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2Abstract: DESCRIPTION (provided by applicant): A major goal in the post-genomic era is to express the vast collection of protein- coding sequences, eventually resulting in a better understanding of protein interactions and the development of novel therapeutics. Themost favored host for heterologous… more
Analytical Metagenomics Paradigm for Structure Based Screening
Company: LUCIGEN CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): Each year, 100,000 Americans perish due to untreatable bacterial infections. The societal benefits of new antibiotic compounds that are effective against numerous multiple drug resistant pathogens would be significant.The best possible source for new antibiotic… more
Mini-Chromosome and Fluorescent Proteins for Expression of Protein Complexes
Company: LUCIGEN CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): Robust expression of multi-subunit protein complexes is crucial for understanding the basic biology of organisms. Expression of the individual components in E. coli or yeast may be quick and cost-efficient, but many mammalian proteins show poor expression or… more
Reactivation of human cells for novel fully human Ab platform
Company: NEOCLONE BIOTECHNOLOGY INTERNATIONAL Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): Monoclonal antibodies (mAbs) have been developed into a highly effective class of therapeutic molecules, with global growth of 37% between 2001 and 2002. Since their discovery in 1975, mAbs have been described as magic bullets with the potential to seek out… more
Ultra High Repetition Rate Multi-Parameter Imaging Diagnostics for Reacting Flows
Company: Orbital Technologies Corporation (ORBITEC) Agency/Program/Year/Phase: DOD / STTR / 2012 / 1Abstract: ABSTRACT: Study of non-stationary phenomena in turbulent combusting flows requires spatial measurements of a set of parameters at kHz rates. Ideally these parameters would include the velocity , temperature, and a relevant species concentration. In response to this need, ORBITEC and the… more
Non-Thermal Sanitation By Atmospheric Pressure Plasma
Company: Orbital Technologies Corporation (ORBITEC) Agency/Program/Year/Phase: NASA / SBIR / 2012 / 2Abstract: ORBITEC's Non-Thermal Sanitation by Atmospheric Pressure Plasma technology sanitizes fresh fruits and vegetables without the use of consumable chemicals and without significantly raising the temperature of the food, so food taste and quality are not affected. Atmospheric pressure plasma is well… more
Lattice Regenerative Cooling Methods (LRCM)
Company: Orbital Technologies Corporation (ORBITEC) Agency/Program/Year/Phase: NASA / SBIR / 2012 / 1Abstract: ORBITEC proposes to develop and demonstrate a novel cooling concept called Lattice Regenerative Cooling Methods (LRCM) for future high thrust in-space propulsion systems. Incorporation of ORBITEC's innovative lattice structures in the fabrication of thrust chambers for expander cycle engine… more