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Surface-Emitting, Monolithic Beam-Combined Mid-Wave IR Quantum Cascade Lasers

Company: Intraband LLC Agency/Program/Year/Phase: DOD / STTR / 2013 / 1
Abstract: The technical objectives of this proposal are: (1) design a grating-coupled surface-emitting (GCSE) active-photonic-crystal (APC) 4.6 micron-emitting quantum-cascade laser (QCL) to deliver 15 W diffraction-limited CW power in the main lobe of the far-field beam pattern; (2) design a GCSE-APC QCL… more

Monolithic Scalable Mid-Infrared Phase-Locked Laser Array

Company: Intraband LLC Agency/Program/Year/Phase: DOD / STTR / 2013 / 2
Abstract: The technical objectives of this proposal are: 1) Design a metal/semiconductor grating-based (i.e., substrate-emitting) Grating-Coupled Surface-Emitting Distributed Feedback Quantum Cascade Laser (GCSE-DFB QCL) emitting at 4.6 microns with high beam quality; and 2) Demonstrate a GCSE-DFB QCL… more

Go Games Civics: Meeting Common Core Standards With Tablet-Enhanced Multiplayer Role Play Games

Company: Filament Games Agency/Program/Year/Phase: ED / SBIR / 2013 / 2
Abstract: GoGames will be a tablet-based multiplayer role-play game for middle school social studies classrooms and will focus on topics in civics. GoGames is intended to enable more efficient and effective implementation of traditional civics interventions by replacing static paper content and training… more

Imaging Software of Functional Connectivity MRI for Alzheimer's Disease

Company: BRAINSYMPHONICS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2013 / 2
Abstract: DESCRIPTION (provided by applicant): This application, Imaging Software of Functional Connectivity MRI for Alzheimer's Disease , is written in response to (PA-11-134) Lab to Marketplace: Tools for Brain and Behavioral Research (SBIR [R43/R44]) . Alzheimer's disease (AD) is the most… more

Water-Equivalent Plastic Scintillation Detectors for Small-Field Radiotherapy

Company: STANDARD IMAGING, INC. Agency/Program/Year/Phase: HHS / SBIR / 2013 / 2
Abstract: DESCRIPTION (provided by applicant): Standard Imaging, Inc. is developing a new generation of radiation dosimeters for small field dosimetry. These small detectors are needed in clinical applications such as stereotactic radiosurgery/stereotactic radiotherapy (SRS/SRT), intensity modulated radiation… more

A Dynamic DNA Discovery Kit: Hand-on Exploration of DNA Structure and Function

Company: 3D MOLECULAR DESIGNS Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): The goal of this project is to design and prototype a dynamic physical model of DNA that students will use in an active learning environment to explore the 3-D structure of double- stranded DNA - and then easily untwistinto a flat, 2-D ladder model in which the… more

SBIR Phase II: Inexpensive and Effecient System for Signal Amplification

Company: ALPHA UNIVERSE, LLC Agency/Program/Year/Phase: NSF / SBIR / 2013 / 2
Abstract: This Small Business Innovation Research (SBIR) Phase II project proposes to develop a new signal amplification system that, while being inexpensive and simple to use, can be combined with antibodies or other probe molecules and can increase detection limits of conventional Enzyme-linked… more

Light weight Rubidium-Metal Vapor Circulating System

Company: Frederick T. Elder & Associates Agency/Program/Year/Phase: DOD / SBIR / 2013 / 1
Abstract: Frederick T. Elder & Associates(FTEA) proposes an approach to the development of a closed-cycle Helium-Rubidium(He-Rb) circulator that allows for FTEA to ensure safety throughout the project, to manufacture a prototype at a reasonable cost using mostly commercial components if selected for Phase… more

Molecular Light Switch for Controlled Gene Expression

Company: LUCIGEN CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): Experimental manipulation of gene expression is a widely used technique that is crucial to much of modern biomedical research. The ability to control the timing and expression level of recombinant genes is central to the production of recombinant protein for… more

RVC - Polymer Plate for improved biomedical analyses by tissue imaging MALDI-TOF

Company: LUCIGEN CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): The genetic basis of disease remains a significant research problem, impacting the fields of cancer biology, neurology, cardiology, development, and even microbiology, as recently realized by the Human Microbiome Project. Determination of the genomic sequence… more

Zero G Mass Measurement Device (ZGMMD)

Company: Orbital Technologies Corporation Agency/Program/Year/Phase: NASA / SBIR / 2013 / 1
Abstract: The Zero G Mass Measurement Device (ZGMMD) will provide the ability to quantify the mass of objects up to 2,000 grams, including live animal specimens in a zero G environment, an innovative because there currently are no such devices available to perform mass measurement of smaller masses (<2000… more

Integrated Composite Rocket Nozzle Extension

Company: Orbital Technologies Corporation Agency/Program/Year/Phase: NASA / SBIR / 2013 / 1
Abstract: ORBITEC proposes to develop and demonstrate an Integrated Composite Rocket Nozzle Extension (ICRNE) for use in rocket thrust chambers. The ICRNE will utilize an innovative bonding approach to join a high-temperature composite nozzle extension to a regeneratively cooled metallic nozzle. The ICRNE… more

Acoustic Resonance Reaction Control Thruster (ARCTIC)

Company: Orbital Technologies Corporation Agency/Program/Year/Phase: NASA / SBIR / 2013 / 1
Abstract: ORBITEC proposes to develop and demonstrate the innovative Acoustic Resonance Reaction Control Thruster (ARCTIC) to provide rapid and reliable in-space impulse without the use of toxic hypergols, delicate catalyst beds, or cumbersome spark systems. The ARCTIC thruster will exceed current reliability… more

Rapid Multiplex Microbial Detector

Company: Orbital Technologies Corporation Agency/Program/Year/Phase: NASA / SBIR / 2013 / 1
Abstract: ORBITEC, in collaboration with Lucigen, proposes a rapid nucleic acid-based detector for spaceflight water systems to enable simultaneous quantification of multiple waterborne pathogens with minimal consumables and crew time. The Rapid Multiplex Microbial Detector (RMMD) amplifies the genetic… more

Synthesis of New, Insensitive Energetic Materials

Company: Orbital Technologies Corporation Agency/Program/Year/Phase: DOD / STTR / 2013 / 2
Abstract: Advanced ordnance and propulsion systems utillize materials, such as RDX and HMX, that provide good performance but cannot meet today"s more stringent safety and environmental requirements. Unfortunately, in newer compounds created to replace them, the performance falls with the sensitivity.… more

High Reliability, Long Lifetime H- Ion Source

Company: Phoenix Nuclear Labs LLC Agency/Program/Year/Phase: DOE / SBIR / 2013 / 1
Abstract: In this work, a long lifetime (greater than 6 months) H- ion source capable of reliably delivering current greater than 10 mA will be designed. The immediate DoE need for this technology is a reliable DC H- ion source that will inject an ion beam into the proposed Project X particle accelerator at… more

Alternative Source for Neutron Generation

Company: Phoenix Nuclear Labs LLC Agency/Program/Year/Phase: DOD / SBIR / 2013 / 1
Abstract: Phoenix Nuclear Labs (PNL) will perform a comprehensive analysis of all existing and proposed neutron generator technologies that do not utilize highly enriched fissile material. These technologies include the flux compression generator, dense plasma focus, high current deuterium-tritium fusion,… more

A High Flux Neutron Generator for Measuring Bulk Residual Stress via Diffraction

Company: Phoenix Nuclear Labs LLC Agency/Program/Year/Phase: DOD / SBIR / 2013 / 1
Abstract: ABSTRACT: Residual stresses can be created in engineered components by most common fabrication processes (e.g., welding, joining, machining, casting, heat treating, press fitting, etc.). They are of particular concern to the aerospace industry because they are difficult to measure and can lead to… more

Liquid Crystal-based Sensors for Detection of Airborne Toxic Chemicals for Integration with Unmanned Robotic Systems

Company: PLATYPUS TECHNOLOGIES, LLC Agency/Program/Year/Phase: DOD / STTR / 2013 / 1
Abstract: We aim to develop lightweight and rugged liquid crystal (LC)-based sensors suitable for integration into small unmanned vehicles, including hand-launched UAVs and throwable robots. For Phase I proof of concept, we propose to develop sensors that detect DMMP, H2S, NO2 and NH3. These gases include… more

hiPS Derived Assay for Screening Hematopoietic Differentiation Toxicant Effects

Company: PRIMORIGEN BIOSCIENCES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: Primorigen Biosciences (R) Abstract Primorigen Biosciences will use SBIR funds to develop a high-throughput toxicology assay system utilizing human ventricular cardiomyocytes (vCMs) differentiated from human induced pluripotent stem cells (hiPSCs). Phase Istudies will convert the small-molecule… more

Polynitroxylated Pegylated Hemoglobin for Traumatic Brian Injury Resuscitation

Company: PRIMORIGEN BIOSCIENCES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: Primorigen Biosciences (R) Abstract Primorigen Biosciences will use SBIR funds to develop a novel commercial assay that measures the toxicity of compounds on human induced pluripotent stem cells (hiPSCs) differentiating into hematopoietic progenitor cells(HPCs) and on HPCs differentiated from hiPSCs… more

Ellipsoid Particles for High Performance LC Separations

Company: PRIMORIGEN BIOSCIENCES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): Primorigen will use SBIR SHIFT funds to develop an array system that can identify chemically-defined surfaces to optimize induced pluripotent stem cell (hiPSC) differentiation and maturation. The platform initially willbe validated for its capacty to help… more

A Novel 3-D System for Cost-Effective Industrial Production of Pluripotent Cells

Company: PRIMORIGEN BIOSCIENCES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2013 / 2
Abstract: DESCRIPTION (provided by applicant): Primorigen Biosciences (R) Abstract Primorigen Biosciences will use Phase II SBIR funds to advance its novel, 3-dimensional system for robust expansion of induced pluripotent stem cells (iPSCs) by a) scaling up iPSC production in 3L bioreactors, b) validating the… more

Neuroimaging tools for presurgical brain mapping

Company: PRISM CLINICAL IMAGING INC. Agency/Program/Year/Phase: HHS / STTR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): The goal of this project is to develop functional magnetic resonance imaging (fMRI) tools to assist the diagnosis and treatment of human patients with a brain tumor or other operable pathology. The specific focus of this proposal is to produce a practical,… more

Presurgical brain mapping with functional connectivity MRI

Company: PRISM CLINICAL IMAGING INC. Agency/Program/Year/Phase: HHS / STTR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): The diagnosis and treatment of patients with brain tumors and other diseases is often critically dependent on functional neuroimaging (e.g. fMRI) to identify healthy brain tissue that must be avoided during invasive surgery or radiation treatment. But,… more