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High-Power, Continuous-Wave 3.0- to 3.5-Micron Emitting Quantum Cascade Semiconductor Laser

Company: Intraband LLC Agency/Program/Year/Phase: DOD / STTR / 2014 / 2
Abstract: The technical objective of this proposal is to demonstrate a Quantum Cascade Laser (QCL) emitting in the 3.0-3.5 & #181;m wavelength region, which employs a metamorphic buffer layer (MBL). It is the goal of this program to develop a QCL single-stripe device which will operate in a single,… more

The Enzymatic Degradation of Quorum-Sensing Signals to Decrease Bacterial Phytopathogenicity

Company: PHYLLOTECH, LLC Agency/Program/Year/Phase: USDA / SBIR / 2014 / 1
Abstract: Quorum-sensing (QS) allows bacterial populations to coordinate gene expression in a cell-density dependent manner and plays a significant role in plant pathogenesis. In gram-negative bacteria, QS is mediated by signaling molecules called acyl-homoserine lactones (AHLs). Our technological innovation… more

SBIR Phase I: New approach for producing increased quantities of human antibodies for research, medical, and biodefense applications

Company: ALPHA UNIVERSE, LLC Agency/Program/Year/Phase: NSF / SBIR / 2014 / 1
Abstract: The broader impact /commercial potential of this Small Business Innovation Research (SBIR) project will address the needs of the antibody market for fast and inexpensive production of antibodies. Antibodies are among the most utilized molecular tools in the life sciences, whose applications span a… more

Novel system for sensitive detection of botulinum neurotoxins

Company: ALPHA UNIVERSE, LLC Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): The existence of terrorist organizations around the world, along with their ability to recruit expertise from physicians and scientists, poses an increasing threat of bioterrorist attack to society. In order to reduce the consequences of such an attack or even… more

Riboswitch Based Methyltransferase HTS Assay for Epigenetic Drug Discovery

Company: BELLBROOK LABS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Epigenetic regulation of gene expression via methylation has been implicated in diverse diseases including cancer, diabetes and inflammation, and high throughput screening for histone methyltransferase (HMT) inhibitorsis an area of intense drug discovery effort.… more

HHSN261201400010C;TOPIC 328 - 3D TISSUE CULTURE SYSTEM FOR TUMOR MICROENVIRONMENT;TITLE: NOVEL AGENTS FOR CANCER DIAGNOSIS AND TARGETED THERAPY; 9 MONTHS FUNDING-PHASE I; CONTRACT PERFORMANCE PERIOD

Company: BELLBROOK LABS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: Not Available

A Novel Antibody Drug Conjugate for Metastatic Renal Cancer Treatment

Company: CENTROSE, LLC Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: Project Summary The incidence of renal cell cancer has been rising steadily and for those that have tumor recurrence after surgery, the prognosis is generally poor. In 2013 an estimated 65,150 new cases and 13,680 deaths will be attributed to renal cancerin the United States. Renal cancer is the… more

Computerized Screening for Comorbidity in Adolescents with Substance or Psychiatr

Company: CENTER FOR PSYCHOLOGICAL CONSULTATION Agency/Program/Year/Phase: HHS / SBIR / 2014 / 2
Abstract: Project Summary This Phase II SBIR grant is a follow-up to the Phase I SBIR grant Computerized Screening for Comorbidity in Adolescents with Substance or Psychiatric Disorders. During Phase I, parent and adolescent self- administered computerized versions of the psychiatric interview, the Kiddie… more

CLIA-waived Point of Care Test of Infection by Cocci, Blasto, and Histo

Company: LUCIGEN CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: Human cytomegalovirus (CMV) infection causes more cases of congenital disease than 29 currently screened conditions in the US combined & several newborn screening disorders in EU countries. Congenital CMV infection rate is 0.7% in developed countries with 18% of infected newborns developing… more

Antifungal Compound Discovery from Metagenomes

Company: LUCIGEN CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): There is societal need for new compounds in our arsenal of defenses against fungal pathogens, many of which are increasingly resistant to existing therapeutics. The best possible source for new antifungal compounds withpotentially novel mechanisms of action is… more

BAC Sudoku Sequencing Paradigm to Accelerate Metagenomic Natural Product Chemistr

Company: LUCIGEN CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): There is societal need for new compounds in our arsenal of defenses against microbial pathogens, many of which are increasingly resistant to existing therapeutics. The best possible source for new antimicrobial compounds with potentially novel mechanisms of… more

Novel Cell-based Real Time Platform for GPCR Drug Discovery

Company: LUCIGEN CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: Abstract High throughput screening assays for GPCR drug discovery are hampered by the complex instrumentation associated with current technologies, and the high risk of false-positives and off- target effects. The majority of currently available GPCR drugscreening assays are end-point assays that… more

New Tools for Structural Variation Analysis, De Novo Assembly and Closing of Complex Genomes

Company: LUCIGEN CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Next-generation sequencing (NGS) platforms are fundamentally altering genetic and genomic research by providing massive amounts of data in a low-cost, high-throughput format. The main drawback of existing technologies is the short sequence read lengths they… more

Molecular Diagnostic Device for Penside Detection of Viral Pathogens Associated with Porcine Respiratory Disease Complex

Company: LUCIGEN CORPORATION Agency/Program/Year/Phase: USDA / SBIR / 2014 / 2
Abstract: Respiratory tract infection in pigs, commonly referred to as "Porcine Respiratory Disease Complex (PRDC)", is a major challenge for the swine industry as it causes significant production and economic losses to producers worldwide. Timely detection of causative agents is required to… more

Electrode Arrays for Bloodless Liver Resection and Tumor Ablation

Company: MEDICAL ENGINEERING INNOVATIONS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2014 / 2
Abstract: DESCRIPTION (provided by applicant): Both primary and metastatic liver cancer is common in the US, and worldwide. The standard treatment for liver cancer is liver resection, where part of the liver containing the tumor is surgically removed. This operationis associated with considerable blood loss,… more

Advanced Reversible Cryogenic Thermal Energy Storage (ARCTES)

Company: Orbital Technologies Corporation Agency/Program/Year/Phase: DOD / SBIR / 2014 / 2
Abstract: ORBITEC proposes to develop the Advanced Reversible Cryogenic Thermal Energy Storage (ARCTES) system, which will provide temporary backup cooling for circulating helium gas coolant in high-temperature superconducting (HTS) systems for naval applications. The ARCTES will rely on an initially-frozen… more

Ultra High Repetition Rate Multi-Parameter Imaging Diagnostics for Reacting Flows

Company: Orbital Technologies Corporation Agency/Program/Year/Phase: DOD / STTR / 2014 / 2
Abstract: ABSTRACT: ORBITEC will develop a new diagnostic to acquire simultaneous planes of velocity and temperature data at very high repetition rates. This diagnostic relies on a novel pulse burst laser system, a phosphor thermometry technique, and the mature PIV method. The work plan will involve… more

Zero G Mass Measurement Device (ZGMMD)

Company: Orbital Technologies Corporation Agency/Program/Year/Phase: NASA / SBIR / 2014 / 2
Abstract: The Zero Gravity Mass Measurement Device (ZGMMD) provides the ability to measure the mass of samples in a microgravity environment, like that found on the International Space Station (ISS). One of the primary measurements often taken during science experiments is mass. This is even more relevant in… more

Miniature Nontoxic Nitrous Oxide-Propane (MINNOP) Propulsion

Company: Orbital Technologies Corporation Agency/Program/Year/Phase: NASA / SBIR / 2014 / 1
Abstract: ORBITEC proposes to develop the Miniature Nontoxic Nitrous Oxide-Propane (MINNOP) propulsion system, a small bipropellant propulsion system which we offer as an alternative to miniature hydrazine monopropellant thrusters for CubeSat-class spacecraft. As compared to state-of-the-art hydrazine… more

Plastic Melt Waste Compactor Flight Demonstrator Payload (PFDP)

Company: Orbital Technologies Corporation Agency/Program/Year/Phase: NASA / SBIR / 2014 / 1
Abstract: The PMWC Flight Demonstrator Payload is a trash dewatering and volume reduction system that uses heat melt compaction to remove nearly 100% of water from trash while significantly reducing the volume. Recent advances have proven that ORBITEC's HEHO-PMWC is a viable technology for producing… more

VTX HyHeat

Company: Orbital Technologies Corporation Agency/Program/Year/Phase: NASA / SBIR / 2014 / 1
Abstract: In this project Orbital Technologies Corporation (ORBITEC) will utilize its unique vortex propulsion technology to develop a high-capacity heating system to heat hydrogen to extremely high temperature levels. The heated hydrogen is to be used for test purposes for nuclear rocket propulsion… more

High Performance Nanolauncher

Company: Orbital Technologies Corporation Agency/Program/Year/Phase: NASA / STTR / 2014 / 1
Abstract: The proposed Low Cost Nanolauncher (LCN) is an upper stage using a new, inexpensive propulsion system. The Phase I program will combine several technologies with a simple design strategy to produce a flight-weight propulsion system that is easy to fabricate and operate. Self pressurizing… more

Liquid Crystal-based Sensors for Detection of Airborne Toxic Chemicals for Integration with Unmanned Robotic Systems

Company: PLATYPUS TECHNOLOGIES, LLC Agency/Program/Year/Phase: DOD / STTR / 2014 / 2
Abstract: In Phase I we successfully reached all goals and milestones in developing liquid crystal sensors that detected 100 ppb of each of four target gases (DMMP, hydrogen sulfide, nitrogen dioxide and ammonia) within 60 seconds. In Phase II, we propose to expand this detection capability to a total of… more

An efficient directed cell migration assay

Company: PLATYPUS TECHNOLOGIES, LLC Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: Project Summary The goal of this SBIR project is to design and develop an efficient, automation- compatible Directed Cell Migration (DCM) 96-well Assay that distinguishes chemokinetic from chemotactic behavior. Cell migration is currently assayed using trans-membrane well inserts, microfluidic… more

An Efficient Fully 3-Dimensional Cell Migration Assay

Company: PLATYPUS TECHNOLOGIES, LLC Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): The goal of this SBIR project is to design and develop an efficient, physiologically relevant and cost-effective 96-well 3-D Cell Migration Assay that is compatible with mid-high throughput/high content assay platforms.Due to its importance in cancer and… more