Preclinical Development of JS-K, a Novel NO-Generating Prodrug for Cancer
Company: JSK THERAPEUTICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2Abstract: DESCRIPTION (provided by applicant): Despite notable achievements over the past two decades, cancer remains a challenging 21st century epidemic demanding new, more effective drugs. Nitric oxide (NO) is well known to kill cancer cells without harming normal bone marrow cells, but until now has not… more
Ultra-High Temperature Thermal Barrier Coatings
Company: Hifunda, Llc Agency/Program/Year/Phase: DOE / STTR / 2012 / 1Abstract: The US Department of Energy has a stated goal to increase the energy efficiency of turbines, and one well recognized method of achieving this is through the use of ceramic thermal barrier coatings (TBCs). However, state of the art zirconia-based TBCs have a temperature limit of about 1200oC, and new… more
Stability Control Improvement and State Detection for Autonomous Vehicles
Company: Autonomous Solutions, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: The proposed research will look at a combination of low-cost radar, stereo camera, and lidar data to generate a 3D model of the terrain ahead of a vehicle. The resulting terrain model will be automatically segmented, simplified and compressed to produce a reasonable description, which can interact… more
Novel Process for Production of Fatty Acids from Lignocellulosic Biomass
Company: Technology Holding, LLC Agency/Program/Year/Phase: USDA / SBIR / 2012 / 1Abstract: Environmental Benefits: The proposed technology relates to Climate change and sustainable energy. Fatty acids are currently produced from palm oil, 80% of which comes from Malaysia and Indonesia. Both these countries have finite land available and often times rainforests are destroyed to make way… more
SBIR Phase II: Near Infrared Substrates for Imaging Autotaxin Activity In Vivo
Company: ECHELON BIOSCIENCES, INC. Agency/Program/Year/Phase: NSF / SBIR / 2012 / 2Abstract: This Small Business Innovation Research (SBIR) Phase II project aims to further develop ATX-Red, an in vivo imaging agent that becomes fluorescent in the presence of the enzyme autotaxin. Autotaxin and its product LPA are involved in numerous biological functions that generally involve cell movement… more
W-band Transmitter
Company: InnoSys Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: ABSTRACT: The Air Force has identified a need for efficient, lightweight, millimeter-wave transmitter development that supports future generations of bandwidth efficient military satellite communications and communications links between Remotely Piloted Aircrafts (RPAs), satellites and terrestrial… more
Cordless Battery Charging
Company: InnoSys Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: Todays warfighter and NETT Warrior are reliant on small battery operated devices for communication, information systems, enemy detection, and battlefield management. These devices must be recharged on a regular basis to ensure sustained operation. Current charging technologies require the device to… more
Advanced Radar Concepts For Small (Tier I/II) RPAs
Company: ImSAR LLC Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: ABSTRACT: ImSAR LLC and Solid State Scientific Corporation (SSSC) propose to leverage ImSAR's proven radar hardware and ground processing capabilities along with SSSC's expertise in radar signal processing, SAR-based GMTI, and automatic/assisted target recognition to advance the state of… more
Non-GPS Dependent Method for Accurate UAS Navigation and Orientation Determination
Company: ImSAR LLC Agency/Program/Year/Phase: DOD / SBIR / 2012 / 2Abstract: ABSTRACT: pending BENEFIT: pending
Implantable Myoelectric Recording Array for Control of Prostheses
Company: RIPPLE, LLC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2Abstract: DESCRIPTION (provided by applicant): The goal of this translational SBIR program is to create a small, implantable system for recording myoelectric signals from residual and reinnervated muscles of individuals with forearm and other amputations. The signals will be wirelessly coupled to an external… more
Utilizing Spread Spectrum Time Domain Reflectometry (SSTDR) to Automatically Detect Ground Faults in Live Shipboard Control Systems
Company: LiveWire Test Labs, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: The use of Spread Spectrum Time Domain Reflectometry (SSTDR) that has already been proven in aerospace applications will be adapted and optimized for detection and location of wiring faults in shipboard systems. SSTDR is the only technology that allows MCS fault detection and isolation, on fully… more
Development of a Robust, Highly Efficient Oxygen-Carbon Monoxide Cogeneration System
Company: Materials & Systems Research, Inc. Agency/Program/Year/Phase: NASA / SBIR / 2012 / 2Abstract: This small business innovation research is intended to develop a long-life, highly efficient O2-CO cogeneration system to support NASA's endeavors to pursue extraterrestrial exploration (Moon, Mars, and Asteroids/Phobos). The cogeneration system will be built using a Tubular, Negative… more
Solid Oxide Fuel Cell Cathode Enhancement Through a Vacuum-Assisted Infiltration Technique
Company: Materials & Systems Research, Inc. Agency/Program/Year/Phase: DOE / SBIR / 2012 / 2Abstract: SOFC technology promises to provide an efficient method by which electricity can be generated from coal-derived syngas, biofuels, and natural gas, while increasing energy security and reducing greenhouse gas emissions. The large capital costs attributed to the cathode low performance and long-term… more
SBIR Phase II: Planar ZEBRA Battery Development
Company: Materials & Systems Research, Inc. Agency/Program/Year/Phase: NSF / SBIR / 2012 / 2Abstract: This Small Business Innovation Research Phase II project is to develop a planar, highly compact, sodium-beta rechargeable battery using sodium-ion conducting beta?- alumina solid electrolyte (Na-BASE) sandwiched between liquid sodium and nickel chloride-based salt, (a p-ZEBRA battery). The… more
Advanced sodium batteries with enhanced safety and low cost processing
Company: Materials & Systems Research, Inc. Agency/Program/Year/Phase: DOE / SBIR / 2012 / 1Abstract: Sodium beta-alumina batteries are one of the most promising large-scale electrical energy storage technologies due to their high energy density and excellent cycling capability. Despite many advantages, the sodium batteries have several barriers for successful commercialization, mainly related to… more
Advanced sodium batteries with enhanced safety and low cost processing
Company: Materials & Systems Research, Inc. Agency/Program/Year/Phase: DOE / SBIR / 2012 / 2Abstract: Sodium beta-alumina batteries are one of the most promising large-scale electrical energy storage technologies due to their high energy density and excellent cycling capability. Despite many advantages, the sodium batteries have several barriers for successful commercialization, mainly related to… more
Protease-resistant D-peptide inhibitors of RSV entry
Company: NAVIGEN, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): Respiratory syncytial virus (RSV) is the major cause of severe lower respiratory tract infections in children and infants, affecting an estimated 64 million people and causing 160,000 deaths worldwide per year (WHO). Each year in the United States, ~100,000… more
Protease-resistant D-peptide Inhibitors of Ebola Virus Entry
Company: NAVIGEN, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): Ebola virus (EboV) is a filovirus that causes a highly deadly hemorrhagic fever in humans and non-human primates. Since its discovery in central Africa in 1976, there have been 16 natural human outbreaks with an averagemortality rate of 67%. There are no approved… more
Submerged Printing of Lipid and Membrane Protein Arrays
Company: Wasatch Microfluidics, LLC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): The goal of this Phase I SBIR project is to develop a device for automated array printing of lipids and membrane proteins onto submerged microtiter plate surfaces in a way that maintains their activity and function. Ourproprietary 3D microfluidic printing… more
Lightweight Structural Materials for Broadband Electromagnetic Hardening
Company: METAL MATRIX COMPOSITES CO. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: ABSTRACT: Lightweight structural composite materials that provide exceptional shielding and hardening performance across a broad range of the electromagnetic spectrum will be demonstrated and developed. BENEFIT: Currently, the electromagnetic hardening requirements are met by the use of metals or… more
Reliability Enhancement and Preliminary Ocean Demonstration of Low Cost Wave Energy Harvester
Company: Oscilla Power, Inc. Agency/Program/Year/Phase: DOE / SBIR / 2012 / 2Abstract: Ocean wave energy has the potential to support 8% of domestic and global electricity demand. Despite considerable investment over the past decade, however, wave energy is unlikely to make a material contribution to domestic or global energy supplies unless new technologies with significantly lower… more
In-situ Gelling Protein Polymer Intravascular Embolic Agent for Hepatic Carcinoma
Company: THERATARGET Agency/Program/Year/Phase: HHS / STTR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): This Phase I proposal addresses the significant need for improved treatment options for patients with liver cancer, the fifth highest incidence of cance in the world. Because of the lack of symptoms, hepatocellular carcinoma (HCC) is detected at advanced stages… more
Frangible Cables, Ladders and other Accessories for"ILS/GS Structures and other Non-visual Aids"
Company: Select Engineering Services Agency/Program/Year/Phase: DOD / SBIR / 2012 / 2Abstract: ABSTRACT: Select Engineering Services (SES) has developed a composite Instrument Landing System (ILS) tower that improves sustainability (by eliminating costly maintenance) and increases airfield safety through a frangible design. Current ILS towers are made from steel components and require costly… more
Energy Efficient Tactical Shelters
Company: Select Engineering Services Agency/Program/Year/Phase: DOD / SBIR / 2012 / 2Abstract: ABSTRACT: During Phase I, SES modeled the fuel consumption of a baseline shelter and then modeled the interactive effects of using fuel efficient technologies (lighting, climate control, etc.) instead of the baseline technologies. This work demonstrated the feasibility of improving the fuel… more
Ko's Journey: Empires
Company: Imagine Education, LLC Agency/Program/Year/Phase: ED / SBIR / 2012 / 1Abstract: This project team is developing a prototype of a web-based pre-algebra math game for middle school students for use on tablet and personal computer platforms. The game, called Empires, will be story-based, strategic, and will enable peer-to-peer interactions. The games will be integrated within… more