Search

Medical Sensor Applications of Tunnel Magnetoresistance (TMR)

Company: KORONIS BIOMEDICAL TECHNOLOGIES CORPORAT Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Koronis Biomedical Technologies (KBT) proposes to develop a novel tunneling magnetoresistance (TMR) sensor for use in medical devices. TMR technology delivers improvements in magnetic sensor size, sensitivity, and noiserejection that represent an opportunity to… more

Neurocognitive Training to Improve Executive Function

Company: KORONIS BIOMEDICAL TECHNOLOGIES CORPORAT Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): In this Phase I STTR project Koronis Biomedical Technologies (KBT) in close collaboration with the Zelazo Lab at the University of Minnesota proposes to develop an electroencephalography (EEG) based neurocognitive training tool to enable individuals to improve… more

AAV Mediated Gene Transfer to the CNS for MPS I

Company: REGENX, LLC Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Mucopolysaccharidosis type I (MPS I) is an autosomal recessive storage disease caused by the absence of a-L-iduronidase (IDUA), resulting in systemic accumulation of glycosaminoglycan (GAG) storage materials, hepatosplenomegaly, skeletal dysplasias,… more

Transdermal Naltrexone for Opiate Addiction and Alcoholism

Company: ALLTRANZ, INC. Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): According to the National Survey of Drug Use and Health (NSDUH) of 2008, 7.2 million Americans are in need of treatment for Substance-Related Disorders (SRDs), and a large proportion of those need treatment for opiate pain reliever, heroin, and alcohol addiction.… more

ASC101 Enhancement of Regenerative Capacity of Amniotic Fluid-derived Stem Cells

Company: AMERICAN STEM CELL, INC. Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): In the present STTR we propose to investigate two novel approaches in our exploration of the therapeutic and regenerative potential of cell-based medicine. Furthermore, we will utilize a preclinical animal model of compression syndrome (CS) that mimics the… more

Breakthrough intra-operative detection of the parathyroid glands

Company: Anasys Instruments Corp Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Currently, about 20 million Americans have some form of thyroid disease. Thyroid disease occurs when the thyroid gland does not supply the appropriate amount of thyroid hormone needed. Thyroid and parathyroid diseases combine the fields of endocrinology and… more

Development of a new Imaging Platform for Pharmaceutical and Biomedical applicati

Company: Anasys Instruments Corp Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): In this project, the breakthrough new technique of nanoscale infrared (IR) spectroscopy, pioneered by Anasys Instruments, will be adapted and refined for Pharmaceutical and biological systems. The technique has numerousapplications such as Polymorph screening;… more

A Binary Probe-Based DNAzyme Cascade for Rapid Detection of MRSA/MSSA

Company: BIODETECTION INSTRUMENTS, LLC Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): A binary probe-based DNAzyme cascade for rapid detection of MRSA/MSSA Project Summary This STTR Phase I project will develop a proof-of-concept molecular test for rapid detection of Staphylococcus aureus (SA) and differentiation between methicillin-resistant SA… more

An Interactive Web-Based Tool to Enhance Consent for Mental Health Research

Company: BEHAVIORAL TECH RESEARCH, INC. Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): The limitations of standard means of obtaining informed consent for psychiatric clinical trials have been well documented. Empirical data suggests that, aided by multimedia learning methods, psychiatric patients can betaught or primed with general knowledge… more

Long-Term Broad-Spectrum Prevention of Implant-Related Infections

Company: BIOMEDICAL DEVELOPMENT CORPORATION Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Deep wound infection following total joint arthroplasty is a devastating complication for physician and patient, a leading cause of morbidity, and a significant economic burden to the healthcare system. With an aging population and increased life expectancies,… more

Wireless Novel MicroEEG for Neonatal Apnea and Community Neurological Network

Company: BIO-SIGNAL GROUP CORPORATION Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Most preterm infants have episodes of apnea (cessation of breathing), bradycardia (low heart rate), and desaturations (low levels of oxygen in the blood) or what is collectively called as ABD events. The resolution of such ABD episodes depends to a large extent… more

A novel 3D microscope for imaging and photostimulation

Company: BOULDER NONLINEAR SYSTEMS, INC. Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Mental disease, including schizophrenia, depression and autism spectrum disorders, are still poorly understood, although it is clear that they mostly represent cortical disorders. The cortex is the primary site of higher mental functions, and despite extensive… more

Mobile Phone Application to Increase Tobacco Cessation Medication Adherence

Company: C/J MEDIA, INC. Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Tobacco is the leading cause of preventable disease and death in the U.S. Although effective tobacco cessation medications exist, the impact of these medications is diminished by lack of adherence by the patient. Basedon our team's expertise in the use of… more

Platform for myocardial infarct MRI and delivery of therapeutics

Company: CELSENSE, INC. Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: Myocardial infarction (MI) afflicts more than one million persons per year in the United States alone. MI results in permanent left ventricle (LV) scarring that causes diminished pump efficiency and, commonly, heart failure. Towards reduction or elimination of scarring, there is increasing interest… more

A novel therapeutic strategy for Acute Lung Injury: Inhibition of PKC-delta

Company: COMPLEGEN, INC. Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Sepsis and the related systemic inflammatory response are the leading causes of death in intensive care units. More than 200,000 people die each year in the US from sepsis and associated complications. The lung is the organ most often affected with pulmonary… more

Rapid intercalator removal from size-selected DNA for next generation sequencing

Company: DIFFINITY GENOMICS, INC. Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Information from next generation sequencing is widely used in translational studies and promises to be a cornerstone of personalized medicine where therapeutic courses are linked to an individual's genetic makeup. Extraction of DNA from gels following… more

A Quantitative Optical Sensor to Monitor Pre-Clinical Tumor Vascular Physiology

Company: ENDLS OPTICS CORPORATION Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Angiogenesis and hypoxia can significantly influence the efficacy of therapy and the behavior of surviving tumor cells. This important fact is supported by a vast amount of literature on pre-clinical models and clinical studies. There is growing demand for… more

Using combinatorial control to improve transgene expression specificity in plants

Company: GRASSROOTS BIOTECHNOLOGY INC Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): It is currently estimated that 15% of the world's population is undernourished and 5 million childhood deaths a year are attributable to malnutrition. The ability to feed the world in the future will be even more difficult due to population growth, climate… more

Speech-based biomarkers of CNS dysfunction associated with early Alzheimers disea

Company: CENTER FOR PSYCHOLOGICAL CONSULTATION Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): More efficient methods to screen and monitor elderly patients in clinical practice and research are needed, but visits to clinical offices are expensive and many older patient are restricted by mobility or transportation access. The Alzheimer's Disease… more

Automating MRI Delta T1 Methods for the Routine Assessment of Brain Tumor Burden

Company: IMAGING BIOMETRICS, LLC Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Contrast enhancement on MRI (magnetic resonance imaging) provides the best currently available approach for measuring tumor response to therapy in brain and other solid tumors. Accordingly, criteria have been formulated, by international committees, to guide the… more

Antigen Detection Assay for the Diagnosis of Melioidosis

Company: InBios International, Inc. Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Burkholderia pseudomallei is a Gram-negative bacterium that is the causative agent of melioidosis. The bacterium causes significant morbidity and mortality in tropical regions and endemic areas are expanding. Melioidosis is difficult to trea and diagnose due to… more

A novel vaccine against vaginal Chlamydia trachomatis

Company: EPITOGENESIS, INC. Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Preventing Chlamydia trachomatis (Ct) infections represent a critical unmet medical need. Development of an effective vaccine would not only reduce the morbidity associated with these infections, including pelvic inflammatory disease (PID), infertility, chronic… more

A new class of biodegradable synthetic biomaterial for seroma prevention

Company: IFYBER, LLC Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Seromas are a common post-operative complication particularly prevalent following ablative and reconstructive surgeries. Without timely intervention post-operative seromas can lead to significant patient morbidity including infection, tissue necrosis, permanent… more

Next Generation Therapeutics for Hemoglobinopathies

Company: PHOENICIA BIOSCIENCES, INC. Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Sickle cell disease and 2-thalassemias are mankind's most common hereditary monogenic diseases, comprise a major global health burden, and cost the US healthcare system gt 1 billion annually. Patients have chronic disabling morbidity and early mortality.… more

Calibrated Methods for Quantitative PET/CT Imaging

Company: Kitware Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): The overall goal of this STTR project is to develop calibrated 3D quantitative analysis tools that directly support improved quantitative accuracy in clinical trials using PET/CT imaging. Pocket phantom technology willbe extended to characterize, perform quality… more