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Novel Therapeutic Approach to Hypercholesterolemia Using Next-Generation DNA Sequ

Company: ABEOME CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): We have developed and completed a proof-of-principle on a new transgenic mouse model for comprehensive characterization of the antibody repertoire made in response to ovalbumin injection using surface antibody capture and next-generation DNA sequencing… more

Fusing Uncertain and Heterogeneous Information Making Sense of the Battlefield

Company: Veloxiti Agency/Program/Year/Phase: DOD / SBIR / 2014 / 2
Abstract: The military"s increasingly capable net-centric environment offers clear benefits and undeniable challenges. Due to the development of new sensor platforms and sensor technologies, physics-based information capabilities have increased but limitations on human/system exploitation capabilities… more

A Microneedle Array System for Transcutaneous Nerve Mapping

Company: AXION BIOSYSTEMS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2014 / 2
Abstract: PROJECT SUMMARY The proposed study combines novel electronics and microfabrication techniques to create a non-invasive, research platform for targeted stimulation and characterization of human peripheral nerves. This Phase II proposal involves two significant developments for high-resolution… more

Passive Wireless Corrosion-Monitoring Tags

Company: EngeniusMicro LLC Agency/Program/Year/Phase: DOD / STTR / 2014 / 2
Abstract: EngeniusMicro and the Georgia Institute of Technology propose a passive wireless sensor platform for the monitoring of corrosion on aircraft and for stored aircraft components. Multiple volumes, chambers, and compartments within aircraft are susceptible to corrosion damage because they are exposed… more

Real Time Structural Health Monitoring of High Velocity Impact Events

Company: EngeniusMicro LLC Agency/Program/Year/Phase: DOD / SBIR / 2014 / 2
Abstract: This effort investigates two specific technologies to detect and monitor structural damage from high-energy impacts and blasts. The two technologies include directional transducers and structural retrofitting concepts. The directional transducers localize impacts, and enable subsequent in situ… more

Wireless Sensors for In-Situ Dry Cask Storage Monitoring

Company: EngeniusMicro LLC Agency/Program/Year/Phase: DOE / SBIR / 2014 / 1
Abstract: Embedded sensors are needed to monitor conditions in high-temperature industrial and power generation equipment. Existing sensor technology is limited by electronics and materials used to manufacture the sensors or by interrogation range in these environments. Developing sensors to overcome both… more

Electrochemical Micro-Capacitors Utilizing Carbon Nanostructures

Company: EngeniusMicro LLC Agency/Program/Year/Phase: DOD / STTR / 2014 / 1
Abstract: Electrochemical double-layer (ECDL) capacitors have tremendous potential as high-power delivery energy storage elements in low-volume and low-weight microelectronics systems. ECDL electrodes based on nanostructured carbon offer the potential for exception

STTR Phase I: Carbon Nanotube Enabled High-Temperature Wireless Sensor System

Company: EngeniusMicro LLC Agency/Program/Year/Phase: NSF / STTR / 2014 / 1
Abstract: This Small Business Technology Transfer Research (STTR) Phase I project will develop innovative sensors based on vertically aligned carbon nanotube (CNT) diode structures to increase the range and performance of wireless microelectromechanical systems (MEMS) sensors in high-temperature environments.… more

Bioengineered factor VIII gene therapy for hemophilia A

Company: EXPRESSION THERAPEUTICS Agency/Program/Year/Phase: HHS / SBIR / 2014 / 2
Abstract: DESCRIPTION (provided by applicant): The overall goal of this proposal is to conduct a gene therapy clinical trial incorporating genetically modified hematopoietic stem cells (HSCs) for persons with hemophilia A. In a series of recent studies, we have shown that the transplantation of… more

Bioengineered Recombinant FVIII

Company: EXPRESSION THERAPEUTICS Agency/Program/Year/Phase: HHS / SBIR / 2014 / 2
Abstract: PROJECT SUMMARY/ABSTRACT The manufacturing of recombinant coagulation factor VIII is a complex, labor and capital intensive endeavor. Of the recombinant proteins currently marketed, coagulation factor VIII is manufactured with the lowest efficiency and isby far the most expensive on a per unit mass… more

Low Magnetic Signature Expendable Unmanned Aerial Vehicle (UAV) for Anti-Submarine Warfare (ASW)

Company: AREA-I Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: The team proposes to leverage their expertise to develop an anti-submarine warfare (ASW) variant of Area-I"s Air-Launched, Tube-Integrated Unmanned System (ALTIUS). ALTIUS, meaning"higher"in Latin, represents a paradigm shift in the performance of small, tube-launched unmanned… more

Multi-Stage, Multi-Phase, High Efficiency, Intelligent, Electrical Energy Conversion Unit for Navy and USMC

Company: Global Technology Connection Inc Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: There is a need by the Navy and USMC for innovative technology solutions to increase electrical energy conversion efficiency and density in order to reduce volume, weight, and cost for efficiently executing land- and sea-based operations that are limited by space, weight and portability. Global… more

Beyond Fault Diagnosis and Failure Prognosis Fault Tolerant Control of Aerospace Systems

Company: Global Technology Connection Inc Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: ABSTRACT: Global Technology Connection, Inc., in collaboration with its academic and industrial partners proposes to develop a hierarchical 3-tier fault tolerant architecture to improve aircraft reliability, safety, and availability. The hierarchical system will support autonomous decisions for… more

Robotic whole organism HTS platform for drug discovery and development

Company: LUMINOMICS, INC. Agency/Program/Year/Phase: HHS / STTR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Our goal is to create a compact, affordable, fully automated, screening system for large-scale drug 2 testing in living small animal disease models (e.g., worms, flies, and fish). Modern drug discovery is 3 driven by high-throughput screening (HTS) systems that… more

NMDA Receptor Subtype Selective Modualtors as Alzheimer's Disease Therapeutics

Company: NEUROP, INC. Agency/Program/Year/Phase: HHS / STTR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Alzheimer's disease (AD) is a devastating neurodegenerative disorder. One of the few drugs used to treat AD is memantine, which inhibits N-methyl-d-aspartate receptors (NMDARs), glutamate receptor subtypes found at nearly all vertebrate excitatory synapses.… more

Smart Shelf Life Tag for Ordnance Health Monitoring

Company: Polymer Aging Concepts Inc Agency/Program/Year/Phase: DOD / SBIR / 2014 / 2
Abstract: This Phase II SBIR project will develop and field test a wireless"Smart Shelf Life"tag for ordnance which provides real time"go/no-go"status of propellant condition without special training or complex equipment. The tag integrates a new propellant health monitoring (PHM) sensor… more

High Range Resolution Radar for Flightline Boundary Surveillance

Company: PROPAGATION RESEARCH ASSOCIATES, INC. Agency/Program/Year/Phase: DOD / SBIR / 2014 / 2
Abstract: ABSTRACT: In Phase I, PRA working with FLIR modified the command and control (C2) software for their Ranger series of perimeter surveillance radars to meet requirements for flightline boundary surveillance. These radars are ideal for this mission with a 30 cm range resolution,>97% probability of… more

Cognitive Modeling for Cyber Defense

Company: SA Technologies, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: The Cyber battlespace is extraordinarily dynamic, complex and challenging, with both human and automated adversaries (bots) acting alone and in concert to achieve the desired aims. Before Cyber defenders can act to guard against these attacks, they must first achieve and maintain a level of… more

Tough Talks: A Disclosure Intervention for HIV+ YMSM

Company: VIRTUALLY BETTER, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION: Surveillance estimates indicate an alarming resurgence of new HIV/AIDS cases among young men who have sex with men (YMSM), highlighting the importance of re-examining prevention modalities and behavior change strategies. After diagnosis, persons living with HIV continue to engage in… more

Experience Success: Virtual Reality Skills Training to Enhance e-Weight Loss

Company: VIRTUALLY BETTER, INC. Agency/Program/Year/Phase: HHS / STTR / 2014 / 2
Abstract: DESCRIPTION (provided by applicant): Overweight and obesity are major health problems, affecting over two-thirds of US adults. Commercially available Internet-based weight loss programs are currently used by millions of overweight/obese individuals in theU.S, but weight losses are often poor, likely… more

Friends, Family, and Food: Interactive Virtual Environments for Children with Food Allergies

Company: VIRTUALLY BETTER, INC. Agency/Program/Year/Phase: HHS / STTR / 2014 / 2
Abstract: DESCRIPTION (provided by applicant): Pediatric Food Allergy (FA) is recognized as a serious public health concern that affects approximately 4-8 percent of children, with symptoms affecting multiple organ systems, including skin, the respiratory tract, andthe GI tract. Food-induced anaphylaxis,… more

Pegasys VR: Integrating Virtual Humans in the Treatment of Child Social Anxiety

Company: VIRTUALLY BETTER, INC. Agency/Program/Year/Phase: HHS / STTR / 2014 / 2
Abstract: DESCRIPTION (provided by applicant): Anxiety disorders are the most common psychiatric disorders among youth, with lifetime prevalence ranging between 18-20% of the general population. Among anxiety disorders, social anxiety disorder (SAD) affects 8% of all youth, resulting in significant short and… more

Myocardial blood flow quantitation with the novel F-18 Flurpiridaz PET imaging tr

Company: SYNTERMED INCORPORATED Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: Coronary artery disease continues to be a major contributor to the cause of death in the United States. The ability to diagnosis CAD in patients at an early stage has improved over the years resulting in reducing the mortality rate. In nuclear medicine/cardiology, the SPECT and PET myocardial… more

Antibodies to O-GlcNAc modified histones for chromatin biology and epigenetic res

Company: GLYCOSCIENTIFIC, LLC Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): O-glycosylation of nuclear and cytoplasmic proteins by a single ?-N-acetyl-D-glucosamine moiety (O-GlcNAc) is a common post-translational modification that is highly dynamic and fluctuates in response to cellular stimuli. This type of glycosylation has been… more

Functional MRI and Behavioral Markers of Successful Service Dogs

Company: Dog Star Technologies LLC Agency/Program/Year/Phase: DOD / STTR / 2014 / 2
Abstract: In Phase II, we will partner with CCI to deploy our fMRI protocol in 50 of their dogs entering advanced training, and determine neural biomarkers that predict successful completion of the course and placement with a human. Because MRI is expensive and lab