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Development of Technologies that Address the Complex Architecture of the Face During the Treatment of Severe Facial Burn Injury

Company: KeraNetics, LLC Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: With the advent of improved body armor and vehicles and the enemy"s use of the improved explosion device (IED) in the most recent conflicts, blast injuries and related burns to the face have become more and more common among our Wounded Warriors. Pathological scarring, which often results in… more

KeraStat(R) Burn Gel and Halofuginone to Prevent Scar Contracture after Burn Injuries

Company: KeraNetics, LLC Agency/Program/Year/Phase: DOD / SBIR / 2014 / 2
Abstract: No currently available burn product has shown efficacy in substantially decreasing wound healing time and preventing scar formation. The goals of this Phase II proposal are to expand on the results obtained in the Phase I study that showed that (1) halofuginone inhibited collagen-mediated… more

Thromboresistant Small Diameter Tissue-Engineered Vascular Grafts

Company: HUMACYTE, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: The overall goal of this Phase I SBIR application is to develop a non-cell-based means of inhibiting coagulation and platelet activation on engineered vascular grafts, so that small-diameter arterial grafts may be available off the shelf. This arterial graft will consist of human engineered tissue… more

Rapid Computer Numerical Control (CNC) Tool-path Programming

Company: Tucker Innovations Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: The proposal seeks to significantly automate the process of producing parts requiring multi-axis milling of sculpted surfaces as required by the Navy for hydro-shapes such as propellers. Harnessing recent university research involving the application of graphical processing units as inexpensive… more

Biosensor Assays for Diagnosis of Chronic HCV Infection

Company: ALDERON BIOSCIENCES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): This Phase I SBIR application is submitted in response to the call by DHHS for new tests for qualitative measurement of HCV RNA for diagnosis of chronic HCV infection in patients. The need is for HCV RNA assays that areas reliable but less expensive and… more

Point-of-Care Tests for Blood Lead Levels in Children

Company: ALDERON BIOSCIENCES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 2
Abstract: DESCRIPTION (provided by applicant): Lead poisoning harms millions of people, yet is an entirely preventable health problem. The objective of this SBIR on Point-of-Care Tests for Blood Lead Levels in Children is to develop a significantly better blood lead test to identify and protect those at… more

AAV2-ASPA-Based Metabolic Intervention for Alzheimer's Disease

Company: ASKLEPIOS BIOPHARMACEUTICAL, INC. Agency/Program/Year/Phase: HHS / STTR / 2014 / 1
Abstract: Abstract We propose to initiate preclinical development of a gene therapeutic targeted to Alzheimer's Disease. The World Health Organization's and Alzheimer's Disease International's report on Dementia (2012) recognizes that the global burden of AlzheimerDisease is forecast to… more

Choroidal Blood Flow Imaging with Spectral Domain OCT

Company: BIOPTIGEN, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Ophthalmic vascular diseases impact millions of Americans. Age-related macular degeneration and diabetic retinopathy are the two major diseases with a well- known vascular factor. The role of the vascular system in glaucoma and retinopathy of prematurity is more… more

Intrasurgical Optical Coherence Tomography

Company: BIOPTIGEN, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Each year, over 20 million ophthalmic surgeries are performed worldwide. Indications for ophthalmic surgery include potentially blinding diseases, such as cataracts, diabetic retinopathy, macular disease, and retinal detachment. Surgeons performing these delicate… more

Game-based Skills Development in Alcohol Assessment and Intervention

Company: CLINICAL TOOLS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 2
Abstract: ? DESCRIPTION (provided by applicant): The Clinical Challenge: Alcohol project seeks to improve outcomes of patients with at risk alcohol use or an alcohol use disorder by improving the alcohol assessment and intervention skills of medical students. Toaccomplish this goal we will build upon our… more

Inhibitor #2 of Protein Phosphatase 2A (I2PP2A) and Asthma

Company: COGNOSCI, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Over 24 million Americans suffer from asthma, which has become a chronic inflammatory disease of the airways characterized by reversible airflow obstruction and bronchospasm together with symptoms of wheezing, coughing,shortness of breath, and chest tightness.… more

Post-IED Hull Inspection Tool

Company: CORVID TECHNOLOGIES, LLC Agency/Program/Year/Phase: DOD / SBIR / 2014 / 2
Abstract: On today"s battlefields, vehicles are at risk of encountering improvised explosive devices (IEDs). Fortunately, not all of these result in complete vehicle loss. Following events at both ends of the severity spectrum, Battle Damage Assessment and Repair (BDAR) and event reconstruction efforts… more

Physical Sub-Model Development for Turbulence Combustion Closure

Company: CORVID TECHNOLOGIES, LLC Agency/Program/Year/Phase: DOD / STTR / 2014 / 1
Abstract: ABSTRACT: Corvid Technologies, in partnership with Clemson University"s combustion modeling group, is pleased to offer a physical sub-model evaluation and development plan for turbulent combustion applications relevant to the Air Force. We will leverage the computational resources and… more

Advanced Opaque Armor Materials and Manufacturing Methods

Company: CORVID TECHNOLOGIES, LLC Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: Corvid Technologies is proposing an inconspicuous armor solution for SOCOM NSCVs that will offer less costly installation than the current steel shell. This effort will benefit from Corvid"s experience in rapid development of specialized low cost armor systems. Armor coverage of the vehicle… more

Hypervelocity Intercept Modeling with First-Principle, Physics-Based Tools

Company: CORVID TECHNOLOGIES, LLC Agency/Program/Year/Phase: DOD / SBIR / 2014 / 2
Abstract: During our Phase I SBIR program for topic MDA-073-019, Hypervelocity Intercept Modeling with First-Principle, Physics Based Tools, we showed the utility of First-Principle Codes (FPC), specifically Velodyne, in modeling missile intercept phenomenology. In addition, we identified a path toward the… more

Modeling High Explosive (HE) Detonation Response and Resulting Debris/Shrapnel Generation from Submunitions Warheads

Company: CORVID TECHNOLOGIES, LLC Agency/Program/Year/Phase: DOD / SBIR / 2014 / 2
Abstract: The objective of this proposed Phase II effort is to continue leveraging first principles physics based codes for modeling the high and low-order explosive response and characterizing the resulting debris for HE submunitions warheads in missile intercepts. Corvid"s approach will include… more

Post Intercept Debris Predictions for Electro-Optical and Infrared (EO/IR) Scene Modeling

Company: CORVID TECHNOLOGIES, LLC Agency/Program/Year/Phase: DOD / STTR / 2014 / 2
Abstract: Corvid Technologies is pleased to offer this STTR Phase II proposal in collaboration with The Johns Hopkins University Applied Physics Laboratory (JHU/APL), Spectral Sciences Inc. and Torch Technologies. Capabilities from each collaborator are being combined toward the ability to perform accurate,… more

SBIR Phase I: Optimized, Cost Effective LED Air Disinfection Reactor

Company: Dot Metrics Technologies, Inc. Agency/Program/Year/Phase: NSF / SBIR / 2014 / 1
Abstract: This Small Business Innovation Research Phase I project addresses the need to improve the state of the art in efficient air disinfection by introducing a novel disinfection reactor developed around an optimized proprietary optical design in conjunction with an engineered suite of wavelengths… more

A Quantitative Optical Sensor to Monitor Tumor Vascular Physiology

Company: ZENALUX BIOMEDICAL, INC. Agency/Program/Year/Phase: HHS / STTR / 2014 / 2
Abstract: DESCRIPTION (provided by applicant): In 2008, there were 47,560 new cases of head and neck cancers (HNC) in the United States. Early detection of new and locally recurrent cancers is clinically important to reduce not only cancer related mortality, but also treatment associated morbidity as it… more

Prime Power System Development for Active Denial Technology (ADT) and High-Power Radio-Frequency (RF) Systems

Company: Higher Power Engineering Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: Higher Power Engineering proposes to develop a compact and lightweight prime power plant operating from JP-8 fuel. Capacity of 155kW continuos, which exceeds the Navy duty-cycle requirements. Unit exceeds all specifications of size, weight, and fuel efficiency. The proposed unit is projected at… more

A Real-Time Fault Management Software System for Distributed Environments

Company: IAVO Research and Scientific Agency/Program/Year/Phase: NASA / SBIR / 2014 / 2
Abstract: Fault Management (FM) is critical to mission operations and particularly so for complex instruments?such as those used for aircraft and spacecraft. FM software and methodologies, however, too often have nagging limitations that restrict utility, and research and development continues to grapple… more

Development of GZ38-1, a Novel Protectant of Chemotherapy-Induced Myelosuppressio

Company: G1 THERAPEUTICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 2
Abstract: DESCRIPTION (provided by applicant): Myelosuppression continues to represent the major dose-limiting toxicity of cancer chemotherapy, resulting in considerable morbidity and mortality along with frequent reductions in chemotherapy dose intensity, which maycompromise disease control and survival.… more

SBIR Phase I: Water Distribution Network Condition Assessment Instrumentation

Company: InfoSense Inc Agency/Program/Year/Phase: NSF / SBIR / 2014 / 1
Abstract: This Small Business Innovation Research Phase I project will focus on the development of instrumentation for the water pipeline industry to assess a comprehensive set of common water pipe failure modes. The water industry faces an aging infrastructure with a fast growing need for maintenance, while… more

Anti-biofilm agents for the treatment of pulmonary infection in cystic fibrosis p

Company: AGILE SCIENCES, INC. Agency/Program/Year/Phase: HHS / STTR / 2014 / 2
Abstract: DESCRIPTION (provided by applicant): The leading cause of mortality in patients with cystic fibrosis (CF) is pulmonary failure from lung infections, and the predominant organism isolated from these infections is the bacterium Pseudomonas aeruginosa. Lung infections of CF patients persist over the… more

EQUIP: Elements Quality Improvement Process for Youth Mentoring Programs

Company: INNOVATION RESEARCH AND TRAINING, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Utilization of research-based and safety-oriented program practices in the youth development field have been associated with positive youth outcomes, and quality improvement processes designed at increasing the utilization of these types of program practices have… more