App for Speech Development for Students with ASD
Company: Handhold Adaptive, LLC Agency/Program/Year/Phase: ED / SBIR / 2012 / 1Abstract: Autism Spectrum Disorders (ASDs) are severe neurodevelopmental disabilities characterized by deficits in social and communication skills and the presence of restrictive, repetitive behaviors. For the 80 percent of individuals with ASDs who speak, prosody—the rhythm, stress, and intonation of… more
Crystallization of Energetic Materials with Limited Solubility
Company: NALAS Engineering Services Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: The energetic material community has a need to produce energetic materials in varying particle sizes and morphologies. Control of particle and morphology allows the formulator to investigate various aspects of processing and performance associated with the energetic material. Unfortunately,… more
Novel Fluorine-Containing Solid Rocket Motor (SRM) Propellant Component
Company: NALAS Engineering Services Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: NALAS proposes to address the challenge for novel fluorine-containing propellant components with a 3-fold approach: 1. Synthesize a fluorinated analog of BTTN as novel fluorinated plasticizer. 2. Prepare fluorinated analogs of hydroxyl-terminated polybutadiene (HTPB). 3. Prepare a novel fluorinated… more
Innovative Predictive Tools for Successful Processing of Propylene Glycol Dinitrate for Production of Otto Fuel II
Company: NALAS Engineering Services Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 2Abstract: During Phase I of this project, NALAS endeavored to conceive a remotely operated trial nitration system that would remove the operator from harm"s way and facilitate the trial nitration process by enhancing data acquisition and enabling the creation of a data library providing guidance on… more
Novel Methods to Improve Performance of Silver-Zinc Batteries
Company: BST Systems Inc Agency/Program/Year/Phase: DOD / SBIR / 2012 / 2Abstract: BST Systems has been engaged in IR & D Projects #7079, #7103 and SBIR Phase I Topic #N101-054 targeting sealed-cell operation, separator improvement, and negative electrode enhancement. The aim is to develop a nearly maintenance-free, sealed-cell that offers overall performance improvement in… more
High-Speed Thermal Imaging of In-Service TBC Blades
Company: Advanced Fuel Research, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 2Abstract: ABSTRACT: The Leadership Agreement signatures on this Commercialization Readiness Program (CRP) project Small Business Innovation Research (SBIR) Technology Transition Plan (STTP 2011-51) formalize an agreement to develop the technology maturation and transition strategies, and pending funding and… more
Sensor Data Fusion
Company: APPLIED MATHEMATICS, INC. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 2Abstract: Use of data from multiple sensors provides the opportunity for improved ballistic missile defense search and tracking. Algorithms for combining multi-sensor data are required. Ballistic missile defense sensor data fusion is a challenging problem because of incompatibility in coordinate systems for… more
Through-the-Sensor Sonar Performance Prediction and Optimization
Company: Applied Physical Sciences Corp. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: Sonar performance predictions are often unreliable due to the lack of accurate information about the acoustic properties of the ocean around the globe. We propose to demonstrate an environmental estimation technique that uses reverberation from active sonar transmissions to infer environmental… more
Marine Mammal Mitigation Miniature Acoustic Detection Subsystem (MADS)
Company: Applied Physical Sciences Corp. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 2Abstract: Applied Physical Sciences Corp. (APS) will develop designs and proof-of-concept devices to demonstrate a marine mammal detection capability for a variant of the AN/SSQ-125 active source sonobuoy. Acoustic transducers, signal processing algorithms, and data interfaces will be developed and tested.… more
Low Frequency Projector for Long Range Acoustic Communications - Phase II
Company: Applied Physical Sciences Corp. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 2Abstract: The Phase II effort consists of a 12-month Base and two 6-month Options. The Base is centered on the design, fabrication, and test of a prototype projector and power electronics. Testing is planned at NUWC Seneca Lake to evaluate the projector"s electro-acoustic performance. The first Option is… more
Functional phenotyping of leukocyte reprogramming in Type 1 diabetes
Company: CIENCIA, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): Type 1 Diabetes (T1D) affects more than 1 million people in the United States Source ADA http://www.diabetes.org/about-diabetes.jsp and is usually diagnosed in children and can lead to blindness, heart disease and kidney failure. A major focus of intervention… more
Paramagnetic Microbead-based Surface Plasmon Microarray Detection of Toxins and T
Company: CIENCIA, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): The proposed work will result in a characterized prototype instrument that will facilitate the identification of a broad range of analytes in small volumes of human blood, urine, saliva and other readily obtainable biological fluids with little sample preparation… more
High-content Label-free Electro-optic Surface Plasmon Resonance Assay Platform
Company: CIENCIA, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): The objective of this Phase I SBIR proposal is the development of a novel instrumentation platform based on Surface Plasmon Resonance (SPR) that if validated would greatly increase the utility of this label-free technology to researchers utilizing high-content… more
Rapid,high content screening of research colonies for polymicrobial infection
Company: CIENCIA, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): Polymicrobial infections are of great concern to the research community because they have a dramatic impact on the productivity research groups, on the reliability of experimental results, and on the progress that can be made in unraveling fundamental biological… more
Improved Dried Biological Specimen Materials, Recovery and Processing for Diagnostics
Company: Connecticut Analytical Corporation Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: Dried blood spot (DBS) analysis has gained recognition in recent years in basic science and clinical diagnostics. This impetus relies upon its numerous advantages over the collection, transport and storage of blood samples obtained by conventional venipuncture. Although there is wide-spread interest… more
SBIR Phase II: Self Calibrating, Wireless, Needle Implantable Sensor for Continuous Glucose Monitoring
Company: BIORASIS, INC. Agency/Program/Year/Phase: NSF / SBIR / 2012 / 2Abstract: This Small Business Innovation Research (SBIR) Phase II project aims to develop a wireless, needle implantable miniaturized (0.5 x 0.5 x 5 mm) sensor for continuous glucose monitoring, with provisions for internal self-calibration that ultimately eliminates the need for frequent, external… more
Bonded Joint Analysis Method
Company: Global Engineering and Materials, Inc. Agency/Program/Year/Phase: DOD / STTR / 2012 / 1Abstract: A combined discrete cohesive interface fracture and continuum damage mechanics initiation and propagation toolkit for Abaqus will be developed for the residual strength prediction of adhesively bonded composite structures subjected to multi-axial loading. This tool will allow us, for the first time,… more
Total Fatigue Life Assessment of Complicated Structures
Company: Global Engineering and Materials, Inc. Agency/Program/Year/Phase: DOD / STTR / 2012 / 1Abstract: Global Engineering and Materials, Inc. (GEM) along with its team members Northwestern University, Lockheed Martin, and Boeing Company, propose to develop an automatic software tool for 2D/3D fatigue crack growth prognosis of complicated structures under multi-axial loading. The XFAT toolkit will be… more
Probabilistic Remaining Useful Life Prediction of Composite Aircraft Components
Company: Global Engineering and Materials, Inc. Agency/Program/Year/Phase: NASA / SBIR / 2012 / 2Abstract: A Probabilistic Fatigue Damage Assessment Network (PFDAN) toolkit for Abaqus will be developed for probabilistic life management of a laminated composite structure with both microcracking induced stiffness degradation and cyclic loading induced delamination crack growth without remeshing. It is… more
High-Fidelity Residual Strength and Life Prediction Tool for Adhesively Bonded Composite Structures
Company: Global Engineering and Materials, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: A hybrid damage initiation and propagation toolkit for Abaqus will be developed for residual strength and life prediction of adhesively bonded composite structures. This tool will for the first time be able to simulate concurrently both the continuum and discrete damage based progressive failure… more
Modeling and Simulation of Hybrid Materials/Structures for Sustainment Applications
Company: Global Engineering and Materials, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 2Abstract: ABSTRACT: A Hybrid Structure Evaluation and Fatigue Damage Assessment (HYSEFDA) toolkit for Abaqus will be developed for advanced hybrid structures under multi-axial and variable amplitude cyclic loading. The tool will be able to characterize arbitrary geometric configurations of fiber metal… more
Fire Simulation and Residual Strength Prediction Tool for Aluminum Ship Structures During and After Fire
Company: Global Engineering and Materials, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 2Abstract: A fully coupled fire-structure interaction module will be developed and implemented within GEM"s Abaqus Fire Interface Simulator Toolkit (AFIST) for fire response prediction in aluminum ship structures. This enhanced AFIST will be able to characterize a 3D complex geometry where its topology is… more
Therapeutic Inhibition of MIF in Rheumatoid Arthritis
Company: L2 DIAGNOSTICS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2Abstract: DESCRIPTION (provided by applicant): The long-term product goal of this project is a small molecule therapeutic to treat rheumatoid arthritis (RA), which acts by reducing the inflammatory response triggered by the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF). Since MIF is… more
Measurement of Beta Cell Death in Diabetes
Company: L2 DIAGNOSTICS, LLC Agency/Program/Year/Phase: HHS / STTR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): All forms of diabetes are characterized by the death of insulin producing cells. In Type 1 diabetes (T1D), this leads to the reliance on exogenous insulin for survival. In addition, there is cell loss in T2D and inindividuals who lose islet or pancreas… more
Small Molecule Antiviral Agents Against Flaviviruses
Company: L2 DIAGNOSTICS, LLC Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: Flaviviruses enter mammalian cells by a mechanism involving a structural rearrangement of the stem region of their envelope protein. The stem region establishes specific molecular contacts with amino acid residues of domain II of the rest of the envelope protein. Our hypothesis is that tetrapeptides… more