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Novel Oxidizer for Ammonium Perchlorate Replacement

Company: NALAS Engineering Services Inc. Agency/Program/Year/Phase: DOD / SBIR / 2014 / 2
Abstract: The DoD requires an increase in performance and density of solid propellants for use on boost, strategic and tactical missile systems. Attaining ingredients with higher energy and density while simultaneously maintaining satisfactory physical properties is extremely challenging. Current low-cost… more

Environmentally Friendly Alternative Synthesis and Process to Manufacture Cost-Effective Hexanitrohexaazaisowurtzitane (CL-20)

Company: NALAS Engineering Services Inc. Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: The treatment of glyoxal with benzyl amine or allyl amine towards the formation of the corresponding tetraazaisowurtzitane cage structure has established a cornerstone in the preparation of caged nitramines and has led to significant research aimed at converting these precursors into compounds of… more

Environmentally Friendly Alternative Synthesis and Process to Manufacture Cost-Effective Hexanitrohexaazaisowurtzitane (CL-20)

Company: NALAS Engineering Services Inc. Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: Preparation of caged nitramines has led to significant research aimed at converting these precursors into compounds of interests such as CL-20. This unique ability highlights the fine balance required from electronic and steric contributions in the formation of the cage structure. We propose to… more

Electronic Thermally Initiated Venting System (ETIVS) Trigger and Thermal Sensor

Company: NALAS Engineering Services Inc. Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: Current Thermally Initiated Venting Systems (TIVS) consist of a thermal sensor, trigger, out-of-line blocking device, initiator, transfer energetic, and linear-shaped charge. TIVS reduce the reaction violence of munitions exposed to cook-off events by scoring the case of the rocket motor, not… more

Regenerable Sorbent for Combined CO2, Water, and Trace-Contaminant Capture in the Primary Life Support System (PLSS)

Company: ADVANCED FUEL RESEARCH, INC. Agency/Program/Year/Phase: NASA / SBIR / 2014 / 2
Abstract: The NASA objective of expanding the human experience into the far reaches of space requires the development of regenerable life support systems. This proposal addresses the development of an integrated air-revitalization system for the space suit used in Extravehicular Activities (EVAs). The… more

Near Real-Time Quantification of Stochastic Model Parameters

Company: Applied Mathematics, Inc. Agency/Program/Year/Phase: DOD / STTR / 2014 / 2
Abstract: Mathematical models of physical and biological systems contain parameters that need to be estimated from measured data. Models with parameters distributed probabilistically require the estimates of a probability measure over the set of admissible parameters. We propose to use frequentist-based… more

Formulation of LbL microparticle vaccine in microneedle array for intradermal del

Company: ARTIFICIAL CELL TECHNOLOGIES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: Abstract The ability of the immune system to recognize and initiate an immune response to foreign particles such as bacteria and viruses has generated interest in development of particulate vaccine technologies. We are developing an innovative approach toproduce particulate vaccines via… more

Synthetic microparticle malaria vaccine

Company: ARTIFICIAL CELL TECHNOLOGIES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 2
Abstract: Abstract This Phase II project will develop a novel synthetic microparticle vaccine for malaria, using the T1BT* epitopes of the circumsporozoite (CS) protein of Plasmodium falciparum, the causative agent of human malaria. There is no approved vaccine formalaria, a disease that causes up to 500… more

High-quality, low-cost GaN single crystal substrates for high-power devices

Company: Fairfield Crystal Technology Agency/Program/Year/Phase: DOE / SBIR / 2014 / 2
Abstract: The proposed project is to demonstrate a novel technique for producing GaN single-crystal boules that yield GaN wafers and substrates suitable for fabrication of GaN high-power devices. The two key attributes of the proposed novel GaN growth technique (a bulk crystal growth technique) are: a high… more

High-Fidelity Residual Strength and Life Prediction Tool for Adhesively Bonded Composite Structures

Company: Global Engineering and Materials, Inc Agency/Program/Year/Phase: DOD / SBIR / 2014 / 2
Abstract: Global Engineering and Materials, Inc. (GEM) along with its team members (National Institute for Aviation Research (NIAR) at Wichita State University, Carnegie Mellon University, and Air Force Research Lab (AFRL)) will develop an add-on toolkit for Abaqus with high fidelity prediction of residual… more

Particulate Composite Mixing Processes

Company: Global Engineering and Materials, Inc Agency/Program/Year/Phase: DOD / STTR / 2014 / 1
Abstract: ABSTRACT: Global Engineering and Materials, Inc. (GEM) along with its team member Columbia University propose to develop a simulation tool for modeling mixing process of multi-particle composite systems and generating the ultimate microstructure. A combined theoretical, numerical, and experimental… more

IGF::OT::IGF - ?A Nutritive Vaccine Adjuvant Against Influenza?

Company: EPITOGENESIS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: Through this project, investigators will evaluate a novel nutritive immune-enhancing delivery system (NIDS) to assess its potential to lower the dose requirement for pandemic influenza vaccines. PUBLIC HEALTH RELEVANCE

Targeted Inactivation of the CCR5 HIV Coreceptor with Peptide Nucleic Acids

Company: L2 DIAGNOSTICS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Over 34 million people are currently living with HIV/AIDS. Combination antiviral therapies have significantly reduced the morbidity and mortality of the disease; however, there is currently no cure for the disease. Discovery that a naturally occurring variant of… more

Sterculic Acid Analogs to Inhibit Macular Degeneration

Company: L2 DIAGNOSTICS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: ABSTRACT The long-term product goal of this project is a small molecule therapeutic for choroidal neovascularization (CNV, the hallmark of wet age-related macular degradation), an abnormal growth of blood vessels in the choroid layer of the eye that results in damage to the retina and consequent… more

A Multivalent Lyme Disease Vaccine Targeting Tick-Host-Pathogen Interactions

Company: L2 DIAGNOSTICS, LLC Agency/Program/Year/Phase: HHS / STTR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): This proposal seeks to develop a novel vaccine against Lyme disease -- by targeting Ixodes scapularis proteins critical for Borrelia burgdorferi transmission from the tick to mammalian host. Earlier work has identifiedfour tick proteins, Salp15, TRE31, tHRF and… more

RNA Detection as an Improved Diagnostic Assay for Human Leptospirosis

Company: L2 DIAGNOSTICS, LLC Agency/Program/Year/Phase: HHS / STTR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Leptospirosis, a zoonotic disease, is an important public health problem worldwide. It is caused by spirochete bacteria belonging to nine species and more than 200 serovars of the genus Leptospira. In the US, there is increasing awareness of the importance of… more

Measurement of Beta Cell Death in Diabetes

Company: L2 DIAGNOSTICS, LLC Agency/Program/Year/Phase: HHS / STTR / 2014 / 2
Abstract: DESCRIPTION (provided by applicant): All forms of diabetes are characterized by the death of insulin producing ? cells. In Type 1 diabetes (T1D) this leads to the reliance on exogenous insulin for survival. Death of ? cells is silent - it cannot be detected in vivo until it has progressed to such an… more

A serologic assay to measure successful Lyme borreliosis antibiotic therapy

Company: L2 DIAGNOSTICS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2014 / 2
Abstract: DESCRIPTION (provided by applicant): Lyme disease (LD) caused by the Ixodes tick-borne spirochete Borrelia burgdorferi (Bb), is the most common vector-borne disease in the United States. Despite public health preventive measures, the annual confirmed caseincidence has risen to over 30,000, the vast… more

Diagnostic Assays for early Lyme Borreliosis using in-vivo expressed antigens

Company: L2 DIAGNOSTICS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2014 / 2
Abstract: DESCRIPTION (provided by applicant): Current testing for Lyme disease is suboptimal because it requires two assay platforms, including one with subjective interpretation of results, and because it has lower sensitivity in the early stage of the illness. Infection with Borrelia burgdorferi, the… more

Morphing Wing Design with an Innovative Three-Dimensional Warping Actuation

Company: Materials Technologies Corporation Agency/Program/Year/Phase: NASA / SBIR / 2014 / 1
Abstract: Advanced wing configurations where traditional control surfaces are replaced by dynamically controlled distribution of wing twist and/or camber can provide significant benefits to aircraft performance, such as reduced vibration and noise, increased fuel efficiency. Elimination of traditional control… more

DiagNostic for Charging PheNomena

Company: Omega-P, Inc. Agency/Program/Year/Phase: DOE / SBIR / 2014 / 1
Abstract: Dielectric materials are ubiquitous in accelerator structures for discovery science, industrial and medical applications. Further use of dielectrics in advanced accelerators, such as the dielectric wake field accelerator, also promises improved performance and cost savings. But undesirable… more

Rapid Food and Water Pathogen Analyzer

Company: REAL-TIME ANALYZERS, INC. Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: The overall goal of this proposed project (through Phase III) is to develop a field-ready, easy to use Pathogen Analyzer to rapidly identify, quantify, and characterize viability of microbial pathogens in food and water at the required sensitivity (e.g. 1-1000 cfu/g). During the Phase I project,… more

Low Gravity Drug Stability Analyzer

Company: REAL-TIME ANALYZERS, INC. Agency/Program/Year/Phase: NASA / SBIR / 2014 / 2
Abstract: The goal of this proposed program through Phase III is to build a space-worthy Drug Stability Analyzer that can determine the extent of drug degradation. It will be able to monitor the drug active pharmaceutical ingredient (API) and its degradation product concentrations as a function of time, as… more

Saliva Analyzer for Diagnosing SRD Patient Drug Use

Company: REAL-TIME ANALYZERS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 2
Abstract: DESCRIPTION (provided by applicant): The overall aim of this SBIR program is to develop a surface-enhanced Raman spectroscopy (SERS) based device for point-of-care analysis of drugs in patient saliva. This device will allow immediate assessment of both prescription and illicit drug use by patients… more

Advanced Small, Lightweight Multi-Fueled 1,000 - 1,500 W Variable Speed Load Following Man-Portable Power Unit

Company: PRECISION COMBUSTION, INC. Agency/Program/Year/Phase: DOD / SBIR / 2014 / 2
Abstract: Precision Combustion, Inc. (PCI) proposes an ultra-compact JP-8 fueling system that will enable a lightweight spark-ignited engine as a man portable multi-fueled 1 1.5 kW generator. This is based on a breakthrough fueling technology that is different from vaporization approaches. This enables… more