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RAMSES

Company: 21st Century Systems, Incorporated Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: ABSTRACT: The floor of an ALC is like a well-orchestrated dance. However, when an unexpected failure occurs, it can introduce significant delays in not only the specific aircraft"s maintenance, but of the entire network of systems. 21st Century Systems, Inc. (21CSi) is in the position to… more

Voxel-based Fusion (VOXION)

Company: 21st Century Systems, Incorporated Agency/Program/Year/Phase: DOD / STTR / 2014 / 1
Abstract: ABSTRACT: In ISR applications, multiple sensors can be employed to achieve more accurate parameters of interest on targets, improving discrimination and detection. But, the proliferation of sensor systems has created a large volume of multi-sensor data across a number of physical spectra. These… more

Low Cost Small Sample Volume High Precision Carbon Dioxide Analyzer

Company: LI-COR BIOSCIENCES, INC. Agency/Program/Year/Phase: DOE / SBIR / 2014 / 2
Abstract: The increasing concentration of carbon dioxide in the atmosphere is changing the earths climate. Climate change will cause periods of extremely high daily temperatures, increase the frequency of heavy rainfall, intensify droughts, increase the maximum wind speed of cyclones, and cause sea levels to… more

Novel Hydrocyanine Probes for the Accurate Detection of Reactive Oxygen Species

Company: LI-COR BIOSCIENCES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Reactive oxygen species (ROS) are involved in numerous cell-signaling pathways. They have been implicated in over 150 diseases including cancer, arthritis, Parkinson's disease, diabetes, myocardial infarction and atherosclerosis. The need to understand the… more

Next Generation Western for high-throughput and high-content protein analysis

Company: LI-COR BIOSCIENCES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): The identification and quantification of specific proteins in complex samples are critical processes in discovering, understanding, and ultimately addressing, the underlying nature of human health and disease. The western blot is a fundamental method used for… more

Silica Colloidal Crystals for High Resolution MALDI-MS of Glycoproteins

Company: LI-COR BIOSCIENCES, INC. Agency/Program/Year/Phase: HHS / STTR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): The product is a slide coated with silica colloidal crystals to combine protein electrophoresis with matrix- assisted laser desorption/ionization mass spectrometry (MALDI-MS) detection, giving superior performance in both. The Phase II proposal will be to develop… more

Adaptable Standardized Modular Infrastructure for Optimal Space Utilization

Company: Pacific Engineering, Inc Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: PEI is proposing to develop and produce a modular, low maintenance and cost-effective shower stalls for the Navy. The effort will design and fabricate shower stalls that require least number of standardized components, are adaptable to different shapes and sizes with optimum space utilization,… more

RADIOGRAPHIC CONTRAST TO DIFFERENTIATE CAVITATED FROM NON-CAVITATED DENTAL CARIES

Company: FIREFLY HEALTH INNOVATIONS NE, INC. Agency/Program/Year/Phase: HHS / STTR / 2014 / 2
Abstract: DESCRIPTION (provided by applicant): This project aims to improve the accuracy of tests for early tooth decay (dental caries), specifically for interproximal surfaces (where the posterior teeth abut one another). In these regions, there is no physical space to visually inspect or probe for caries.… more

SBIR Phase II: PET Radiotracer Synthesis

Company: Ground Fluor Pharmaceuticals, Inc. Agency/Program/Year/Phase: NSF / SBIR / 2014 / 2
Abstract: This Small Business Innovation Research Phase II project develops positron emission tomography (PET) imaging products to manage neurodegenerative disorders, cancer, and cardiovascular disease. PET is now a key diagnostic and management tool in oncology, and compounds labeled with [18F]-fluoride… more

SBIR Phase I: A Semantic Data-Driven Human Capital Recommendation System

Company: Green Schingle LLC Agency/Program/Year/Phase: NSF / SBIR / 2014 / 1
Abstract: This SBIR Phase I project proposes to apply the combination of semantic matchmaking and a knowledge acquisition loop to human capital selection processes to generate a rank-ordered short-list of qualified candidates. The problem with available job matching methods is they rely primarily on keyword… more

Mucins in the Diagnosis and Prognosis of Pancreatic Diseases

Company: SANGUINE DIAGNOSTICS AND THERAPEUTICS Agency/Program/Year/Phase: HHS / STTR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Due to its asymptomatic nature and lack of methods for early detection, gt 80% of pancreatic cancer (PC) patients present with an unresectable primary tumor with distant metastasis at the time of diagnosis. While the overall 5 year survival rate of pancreatic… more

Autonomously Locating to Perch and Stare (ALPS)

Company: 21st Century Systems, Incorporated Agency/Program/Year/Phase: DOD / SBIR / 2013 / 1
Abstract: Small Unmanned Air Systems (SUAS) are being developed for numerous applications, but size and weight constraints severely limit the capability and endurance of such vehicles. Many missions could be extended by landing for certain periods, entering a low-power state, and re-launching as needed,… more

Low Cost Small Sample Volume High Precision Carbon Dioxide Analyzer

Company: LI-COR BIOSCIENCES, INC. Agency/Program/Year/Phase: DOE / SBIR / 2013 / 1
Abstract: LI-COR Biosciences proposes to develop a new sensor that measures the concentration of carbon dioxide in the atmosphere with precision of 1 part in 3000 within one minute, requires only small amounts of gas, operates unattended in the field for at least 6 months, costs less than $5000, and is… more

Improving Obesity Outcomes Through Interactive Web-Based Clinical Skills Training

Company: NATURE TECHNOLOGY CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): To commercialize non-viral gene medicines, it is critical that both vector potency (i.e. therapeutic transgene expression levels) and the duration of the therapeutic effect be improved. Potent dose-sparing extended duration gene therapies will have a cost and… more

Temperature-Tolerant COLD-PCR enables mutation-enriched targeted re-sequencing

Company: TRANSGENOMIC, INC. Agency/Program/Year/Phase: HHS / STTR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): Cancers develop from the life-long accumulation of critical somatic mutations due to DNA-damaging agents that lead to cells transforming into tumor-forming cells. These low-level tumor-associated somatic DNA mutations can have profound implications for… more

SBIR Phase I: Wise-Irr: Smart Irrigation via Wireless Underground Sensors

Company: Wildsense Agency/Program/Year/Phase: NSF / SBIR / 2013 / 1
Abstract: This Small Business Innovation Research Program (SBIR) Phase I project investigates the feasibility of novel wireless underground communication technologies for real-time agriculture field monitoring to establish the proper timing and amount of irrigation for greatest effectiveness. Existing… more

IMPROVING THE TREATMENT OF CONTAMINATED AQUIFERS BYDEVELOPING DIRECT-PUSH OXIDAN

Company: AIRLIFT ENVIRONMENTAL, LLC Agency/Program/Year/Phase: HHS / STTR / 2013 / 1
Abstract: DESCRIPTION: Water quality is one of the biggest issues related to public health in the United States. Few situations incite more public outcry than when a community learns that their drinking water has been tainted. Two of the biggest threats to groundwater quality in the U.S. are contamination… more

SHARE Under Uncertainty

Company: 21st Century Systems, Incorporated Agency/Program/Year/Phase: DOD / STTR / 2012 / 1
Abstract: In the GMD battlespace, it"s critical to rapidly ascertain specific identifying characteristics of a track so follow-on sensors can match the same track. Currently, sensors communicate track data with differing biases and uncertainties with little data-rich content and attempts to utilize track… more

Fusion with Uncertainty Reasoning using Nested Assessment Characterizer Elements (FURNACE)

Company: 21st Century Systems, Incorporated Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1
Abstract: Situation/threat modeling and threat prediction require higher levels of data fusion to provide actionable information to the warfighter. Beyond sensor data and sources the analyst has control over, the use of out-sourced and re-sourced data are becoming more common. However, the current data fusion… more

Self-Regulating Anomaly Detector (SeRADe)

Company: 21st Century Systems, Incorporated Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1
Abstract: Today"s intelligence exploitation has an information challengethere is a great deal of data being processed by a large number of analysts with insufficient ability to identify anomalies in the data. The process needs a capability that can facilitate a rapid understanding of complex information… more

Agent-Enabled Logistics Enterprise Intelligence System (AELEIS)

Company: 21st Century Systems, Incorporated Agency/Program/Year/Phase: DOD / SBIR / 2012 / 2
Abstract: Army logisticians and fleet managers need an effective method to extract actionable information from their large data stores. They need to extract root cause and case-based analysis to diagnose or predict breakdowns. An Enterprise Intelligence System that extracts data from multiple sources, fuses… more

Development of Ultrafine Particles for Intranasal Delivery of Antipsychotics

Company: LNKCHEMSOLUTIONS Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION: The goal of the proposed project is to develop a biocompatible ultrafine particle-based vector system for the intranasal delivery of clozapine for the pharmacological therapy of treatment- resistant schizophrenic disorders and their associatedsuicidal behavior. The rationale behind the… more

Early Detection of Pancreatic Cancer Using Ice COLD-PCR

Company: TRANSGENOMIC, INC. Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Ninety percent of all pancreatic cancers are pancreatic ductal adenocarcinoma (PDAC). PDAC diagnosis is difficult, usually occurring in the late stages of disease. Patients with these advanced tumors typically respondpoorly to therapy. Post diagnosis, median… more

Ex Vivo Tolerance for Xenotransplantation of Diabetes P2

Company: XIMEREX, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2
Abstract: DESCRIPTION (provided by applicant): Type I diabetes is a widespread disease in which insulin producing pancreatic islets are lost, leading to unstable glucose levels. If the islets can be replaced, as with transplantation, then diabetes can be reversed.Human islets have limited utility because of… more

Lightweight RSG Launcher Components and AURE Composite Cansiters

Company: Pacific Engineering, Inc Agency/Program/Year/Phase: DOD / SBIR / 2012 / 2
Abstract: NAVSEA Undersea Defensive Warfare Systems Program office is developing a Surface Ship Torpedo Defense program that utilizes Anti-Torpedo-Torpedo (ATT) hard kill capability for high value unit (HVU) platforms (Carriers and Combat Logistics Force (CLF) ships). The CAT, a hard kill countermeasure,… more