SBIR Phase I: Development and Validation of an In Vitro Diagnostic of HDL Cholesterol Efflux and Coronary Artery Disease Risk
Company: Accent Assays, Inc. Agency/Program/Year/Phase: NSF / SBIR / 2013 / 1Abstract: This Small Business Innovation Research (SBIR) Phase I project will develop a new approach to accurately predict coronary artery disease (CAD) risk. Because high-density-lipoprotein (HDL) protects from CAD, current methods to assess risk measure the cholesterol content of HDL (HDL-C) as a surrogate… more
RF Sensing of Personnel in Wooded Areas
Company: TrellisWare Technologies, Inc. Agency/Program/Year/Phase: DHS / SBIR / 2013 / 1Abstract: Perhaps because it is the world's longest undefended border, smuggling is endemic across the our northern frontier with Canada. Since a 5,525 mile
border cannot be effectively patrolled on foot, the Department of Homeland Security (DHS) must rely on technology to detect and track smugglers.
Radio… more
Innovative Solutions to Effectively Enforce Anti-texting Rules on Commercial Motor Vehicle (CMV) Drivers
Company: Savari Inc. Agency/Program/Year/Phase: DOT / SBIR / 2012 / 1Abstract: Distracted driving could have severe repercussions leading to loss of life, loss of property, and expensive lawsuits. While there can be many reasons for the driver to get distracted, research shows that the probability of accidents from texting/web-surfing while driving is an order of magnitude… more
SmartWorkZone - Situational awareness messages in the vehicle when driving through a work zone area.
Company: Savari Inc. Agency/Program/Year/Phase: DOT / SBIR / 2012 / 1Abstract: Congestion due to a work zone can cause accidents, as the drivers may not be prepared to take sudden actions ahead of a work zone or in some cases may not have enough visibility/time. Transmitting alert messages in advance can enable the driver to take safety precautionary measures so that it is… more
Ototoxicity protection with intratympanic steroid implant
Company: O-RAY PHARMA, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): Chemotherapy-induced ototoxicity is damage to the inner ear that is caused by the side effects of administered drugs. This can lead to permanent hearing loss and/or tinnitus (continuous ringing in the ear) in the patient. Some of the most common kinds of drugs… more
Oral, replicating Ad4-HIV vaccine development and evaluation in NHP challenge model
Company: PAXVAX, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2Abstract: DESCRIPTION (provided by applicant): Development of a vaccine to prevent, or reduce the rate of, HIV infections remains a high priority despite recent setbacks in the field. The lessons from failed and successful experimental programs indicate the need toapply new approaches to HIV vaccine design… more
Replicating Ad4-HIV vaccine development based on improved HIV Env and GBV-C E2
Company: PAXVAX, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): Development of a vaccine to prevent, or reduce the rate of, HIV infections remains a high priority despite recent setbacks in the field. The lessons from failed and successful experimental programs indicate the need toapply new approaches to HIV vaccine design… more
Use of Spray-Drying as a Manufacturing Process for Oral Adenovirus Vaccine
Company: PAXVAX, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): The 2009 H1N1 pandemic illustrates a critical weakness in our ability to respond to a pandemic threat. The ability to ramp up production of vaccine doses within the critical period from the discovery of the threat is hindered by two major supply constrictions: 1)… more
High-Efficiency Data-Rate-Scalable Laser Transmitter for Interplanetary Optical Communications
Company: RAM Photonics Agency/Program/Year/Phase: NASA / SBIR / 2012 / 1Abstract: Interplanetary missions are at the core of NASA's current space exploration program and are expected to lead the way to new resource discovery in the next decade and beyond. In the absence of manned craft, the payoff for a given mission rests in its ability to gather data and transmit it back… more
A therapeutic Fc gamma Fel d1 chimeric protein vaccine to treat cat allergy
Company: TUNITAS THERAPEUTICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2Abstract: DESCRIPTION (provided by applicant): The overall goal of this phase 2 SBIR proposal is to develop and commercialize a novel biologic for allergen- specific immunotherapy as effective treatment for cat allergy/asthma. Cat allergy is common, with 17% of USpopulation, age 6-59, being skin test… more
Therapeutic peanut allergen Fc gamma chimeric proteins to treat peanut allergy
Company: TUNITAS THERAPEUTICS, INC. Agency/Program/Year/Phase: HHS / STTR / 2012 / 2Abstract: DESCRIPTION (provided by applicant): The overall goal of this Phase 2 STTR is to develop and commercialize a novel approach for allergen specific immunotherapy as a treatment for severe food allergy. Currently treatment to prevent severe food reactions isa major unmet need. There is no effective… more
Portable Lab-on-a-chip Flow Cytometer: Prototype and Application Development
Company: NANOSORT, LLC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2Abstract: DESCRIPTION (provided by applicant): Portable Lab-on-a-chip Flow Cytometer: Prototype and Application Development NanoSort RESEARCH and RELATED Other Project Information 7. PROJECT SUMMARY The lab-on-a-chip NanoSort device proposed here advances the achievements of the Phase I Beta Prototype project… more
Ion Channel Drug Discovery Using Photoswitch Technology
Company: PHOTOSWITCH BIOSCIENCES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2Abstract: DESCRIPTION (provided by applicant): Ion channels are membrane proteins that allow the selective movement of charged molecules through cellular membranes. Many disease states, such as cystic fibrosis, muscular dystrophies, hypertension, and cardiac arrhythmias are caused by ion channel pathologies.… more
Quantitative Characterization of SubMicron Aggregates for Antibody Therapeutics
Company: NANOIMAGING SERVICES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2Abstract: DESCRIPTION (provided by applicant): Aggregation in antibody therapeutics is a topic of increasing concern in the biopharmaceutical industry, as these aggregates are believed to play an undesirable role resulting in adverse health effects to patients by inducing immunogenicity, altering therapeutic… more
Markerless motion capture for the clinical assessment of human movement
Company: ANIMOTION, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2Abstract: DESCRIPTION (provided by applicant): The overall objective of this project is to productize and commercialize a markerless motion capture system for applications in biomechanical and clinical practice. The markerless system, as opposed to traditionally used marker based systems, would provide… more
Nonpeptide Kisspeptin Antagonists for PCOS and HPG axis control
Company: CRINETICS PHARMACEUTICALS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): During the past decade, the discovery of kisspeptin peptides and their cognate receptor KISS1R (aka GPR54) has expanded our mechanistic understanding of the hypthothalamic-pituitary-gonadal (HPG) axis. The kisspeptin system has been shown to be an integrator of… more
RF/EO Track Correlation and Characterization (RETC2)
Company: ExoAnalytic Solutions, Inc Agency/Program/Year/Phase: DOD / STTR / 2012 / 1Abstract: In order to counter emerging threats from the Middle East and Southeast Asia, the Ballistic Missile Defense System (BMDS) is acquiring new sensor (e.g. AN/TPY-2 and PTSS) and weapon technology (SM-3). As these new technologies becomes fielded, the BMDS's Command, Control Battle Management and… more
Exploitation of Networked Sensor Phenomenology Involving Robust Estimation (ENSPIRE)
Company: ExoAnalytic Solutions, Inc Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: One of the primary research objectives for multi-sensor data fusion within the Ballistic Missile Defense System (BMDS) is the development of novel techniques to enable robust target discrimination. While great strides have been made in recent years to advance capabilities through the use of… more
Ontological Sensor Management and Real-time Tasking (O-SMART)
Company: ExoAnalytic Solutions, Inc Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: Missile Defense Agency (MDA) recently adopted the Phased Adaptive Approach (PAA) to enhance the Ballistic Missile Defense System"s (BMDS) ability to counter emerging threats in the Middle East and Southeast Asia. PAA primarily focuses on fielding new sensor technology (e.g. AN/TPY-2, ABIR, and… more
Stellar Track and Radiance Simulation (STARS)
Company: ExoAnalytic Solutions, Inc Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: ExoAnalytic Solutions proposes to develop a star catalog and in-band irradiance simulation by leveraging our in house star background model called STARS (Stellar Track And Radiance Simulation) v1.0 and the Exo6Sim optical focal plane scene generation simulation. STARS v1.0 uses a stellar spectrum… more
Semantically Enabled Event Reasoning
Company: ExoAnalytic Solutions, Inc Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: ABSTRACT: Over the past twenty years, the United States and other nations around the world have become dependent on space technology for communications, precision tracking and many other applications, causing the space domain to become both contested and congested. To maintain Unites States space… more
Reconfigurable/Reprogrammable Communications Systems
Company: Pacific Microchip Corp. Agency/Program/Year/Phase: NASA / SBIR / 2012 / 1Abstract: NASA's latest effort in developing a common platform for space communication and navigation systems is the Space Telecommunications Radio System (STRS) standard. It defines architecture enabling interoperability of Software Defined Radio (SDR) components. Future proof, power conscious… more
Low-power Cross-Correlator ASIC
Company: Pacific Microchip Corp. Agency/Program/Year/Phase: NASA / SBIR / 2012 / 1Abstract: Pacific MicroCHIP Corp. offers to design an ASIC that includes a cross-correlation unit together with the interfaces to be connected to the output of the GeoSTAR's receivers, multiplexer and output interface for the GeoSTAR's system-level integration. The proposed novel ASIC required by… more
Transceiver ASIC for 100Gbps Detector Data Link
Company: Pacific Microchip Corp. Agency/Program/Year/Phase: DOE / SBIR / 2012 / 1Abstract: The Facility for Rare Isotope Beams (FRIB) employs extremely complex instrument, involving thousands of detector elements that generate unprecedented amount of experimental data. Reliable extremely high data throughput standard compliant interfaces that consume low power and are capable of operation… more
Design Tools For Tela Canvas Highly Regular Circuit Geometries
Company: Tela Innovations, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 2Abstract: Through this DARPA SBIR Phase II program, we plan to extend our previous point-solution demonstration (DARPA seedlings) to include logic, SRAM, and IO's and deliver the EDA tool to enable DoD ASICs to take full advantage of our commercial experience. Our Phase I effort to date has shown a… more