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Scalable, Secure Associative Database

Company: Applied Technical Systems Inc. Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: The Associative Model of Data offers a fundamentally different meta-model for data organization than the well-established relational data model. The associative model focuses on Items and Links among items rather than sets of records. We propose to compare and contrast the associative model with two… more

A Variable Pulse Width, Voltage, and Repetition Frequency IGBT-based High Power Radio Frequency Source Driver

Company: Eagle Harbor Technologies, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: The United States Navy is interested in developing small vessel mounted and man-portable directed energy weapons. One key technology in this endeavor is the development of high power radio frequency (HPRF) sources. While much work is being done to advance the state of the art in HPRF sources, the… more

Minimal Residual Disease Monitoring by T-cell Receptor Repertoire Profiling

Company: ADAPTIVE TCR CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): Minimal Residual Disease Monitoring by T-cell Receptor Repertoire Profiling T-cell neoplasms are generally more aggressive and have poorer outcomes than comparable B-cell lymphomas. In addition, for many of these patients, prognosis following disease relapse is… more

Correlating TCR diversity to immune reconstitution after cord blood transplant

Company: ADAPTIVE TCR CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2013 / 2
Abstract: DESCRIPTION (provided by applicant): Many patients requiring stem cell transplantation for hematological malignancies are unable to find a suitable HLA-matched sibling or unrelated donor. Transplants using stem cells from umbilical cord blood provide an alternative for these patients, allowing… more

Vaccine Adjuvant for Rapid Tolerance Induction in Allergy Patients

Company: TRIA BIOSCIENCE CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): Allergy is a major cause of illness and disability with an estimated 40-50 million people afflicted in the US alone. AIT provides long-term benefits for the patient and its need for optimization creates a compelling business opportunity. There is a very strong… more

An automated, atomic fluorescence-based, field deployable groundwater mercury monitoring system

Company: Brooks Rand Ltd Agency/Program/Year/Phase: DOE / SBIR / 2013 / 2
Abstract: Monitoring mercury contamination in groundwater, surface water, and other natural environments is challenging and expensive, and because samples have to be collected in the field and analyzed in a laboratory, there is a long delay before results are available. The expense of monitoring limits the… more

High-Resolution and Frequency, Printed Miniature Magnetic Probes

Company: Eagle Harbor Technologies, Inc. Agency/Program/Year/Phase: DOE / SBIR / 2013 / 1
Abstract: In modern fusion concepts, inductive pickup loops are one of the primary magnetic diagnostics in tokamaks and small-scale concept exploration experiments. They are used in industries and laboratories that utilize and study low-temperature plasmas. Inductive pickup loops are capable of extremely… more

Development of a Plasma Injector for Supersonic Drag Reduction

Company: Eagle Harbor Technologies, Inc. Agency/Program/Year/Phase: NASA / SBIR / 2013 / 1
Abstract: Methods to reduce the turbulent viscous skin friction stand out as paramount to increasing the energy efficiency, and therefore the aerodynamic efficiency of supersonic aircraft. Eagle Harbor Technology (EHT) proposes to develop and optimize a MHD plasma injector, which will be used to efficiently… more

Novel, Very Wide-Bandwidth Characterization Technique

Company: EOSPACE Inc Agency/Program/Year/Phase: DOD / SBIR / 2013 / 1
Abstract: EOSPACE proposes developing a practical, very-wide-bandwidth electrical characterization technique based on advanced photonic signal processing. The characterization method only requires a high-speed mm-wave source and uses exclusively low-speed optical detection, eliminating the need for high-speed… more

Electromagnetic-Attack-Resistant Electro-Optic LiNbO3 Modulator

Company: EOSPACE Inc Agency/Program/Year/Phase: DOD / SBIR / 2013 / 1
Abstract: The objective is to develop a wideband, high-sensitivity, high RF power handling optical modulator suitable for use in low-noise microwave photonic links associated with military and commercial antenna applications. Specifically, the modulator will be designed to be highly-resistive to… more

Autologous HIV-1 resistant T cells through accelerated CCR5 gene disruption

Company: PRECISION GENOME ENGINEERING, INC. Agency/Program/Year/Phase: HHS / STTR / 2013 / 2
Abstract: DESCRIPTION (provided by applicant): Treating patients infected with Human Immunodeficiency Virus-1 (HIV-1) is a substantial clinical challenge with evolving pharmaceutical drug and dosing options. Treatments should improve the health and quality of life for HIV-infected individuals by reducing… more

Low-Energy Rotary Shear for Sub-millimeter Particle Production

Company: Forest Concepts, Llc Agency/Program/Year/Phase: DOE / SBIR / 2013 / 1
Abstract: Inexpensive biofuels are essential to the national economic and environmental stability of the United States. Pathways are well established to ferment sugars derived from biomass into fuels and bioproducts. However, there is a massive gap between the physical form of raw cellulosic biomass and the… more

Programmable Picosat Transceiver

Company: Tethers Unlimited, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2013 / 2
Abstract: ABSTRACT: The goal of the Space Test Program is to enable the US Air Force to rapidly develop emerging space technologies by providing economical flight opportunities to increase a technology"s TRL. Over the past decade, the CubeSat form factor has emerged as an economical platform for testing… more

SWIFT-HPX - High Data Rate Ka-band Commications for Small Satellites

Company: Tethers Unlimited, Inc. Agency/Program/Year/Phase: NASA / SBIR / 2013 / 1
Abstract: Leveraging TUI's SWIFT software defined radio (SDR) architecture, we propose to develop a 100 Mbps downlink and intersatellite crosslink capability with ranging and timing synchronization capabilities to enable more sophisticated CubeSat and small satellite missions. This effort will focus on… more

SWIFT-nanoLV Avionics Platform

Company: Tethers Unlimited, Inc. Agency/Program/Year/Phase: NASA / SBIR / 2013 / 1
Abstract: With the increased demand for and utility of nano- and micro-satellites, the demand for responsive, low-cost access to space has also increased. To meet this demand, multiple private companies are pursuing the development of nano- and micro-launch vehicles (NMLV). However, NMLV builders lack… more

TRUSSELATOR - On-Orbit Fabrication of High Performance Support Structures for Solar Arrays

Company: Tethers Unlimited, Inc. Agency/Program/Year/Phase: NASA / SBIR / 2013 / 1
Abstract: TUI proposes to develop and demonstrate a process for fabricating high-performance composite truss structures on-orbit and integrating them with thin film solar cell assemblies to enable the deployment of very large solar arrays with lower cost and increased power-per-mass than SOA array… more

Sensing and Positioning on Inclines and Deep Environments with Retrieval [SPIDER]

Company: Tethers Unlimited, Inc. Agency/Program/Year/Phase: NASA / SBIR / 2013 / 1
Abstract: To enable future robotic exploration systems to have greater mobility, sensing, sampling, and communication capabilities on difficult terrain such as craters, cliffs, gullies, and skylights, Tethers Unlimited proposes to develop a "Sensing and Positioning on Inclines and Deep Environments with… more

Versatile Structural Radiation Shielding (VSRS)

Company: Tethers Unlimited, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2013 / 2
Abstract: ABSTRACT: The Phase I Versatile Structural Radiation Shielding (VSRS) Effort has successfully demonstrated the feasibility of 3D printing multifunctional spacecraft structures with integral multi-layer, multi-material, minimum-mass radiation shielding. We developed novel space-compatible materials… more

MULTI-FUEL PROCESSOR FOR PORTABLE POWER

Company: InnovaTek, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2013 / 2
Abstract: The quiet operation and high efficiency of fuel cells provide an ideal solution for portable electric power generation for a wide range of military and commercial applications. A compact and efficient fuel processor that provides hydrogen from multiple types of liquid fuels will allow fuel cell… more

Tool for non-invasive delivery of central nervous system drug candidates

Company: IMPEL NEUROPHARMA, INC. Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): Animal models of disease are transforming preclinical research, allowing critical insights into disease mechanisms and evaluation of new therapeutics. While the utility and availability of animal models in research isswiftly expanding often the research tools… more

High Efficiency 808-nm VCSEL Arrays with Excellent Beam Quality

Company: nLight Photonics Agency/Program/Year/Phase: DOD / SBIR / 2013 / 1
Abstract: Today"s high energy Q-switched Nd:YAG lasers are often pumped by stacks of multiple edge-emitting diode laser bars since the vertical-cavity surface-emitting laser (VCSEL) traditionally have been lower in efficiency. In this effort we are proposing a novel VCSEL design which overcomes the… more

Wavelength Stabilized Two Dimensional External Cavity Arrays for Pumping Alkali Vapor Laser Systems

Company: nLight Photonics Agency/Program/Year/Phase: DOD / SBIR / 2013 / 1
Abstract: nLIGHT proposes a two dimensional Wavelength Stabilized Vertical External Cavity Surface Emitting Lasers (WS-VECSEL) as a pump source for Rb vapor alkali laser used in directed energy weapons. The integration of a narrow-band reflector (i.e. a volume holographic grating) into the external cavity… more

High-Efficiency Resonantly Pumped 1550-nm Fiber-Based Laser Transmitter

Company: nLight Photonics Agency/Program/Year/Phase: NASA / SBIR / 2013 / 1
Abstract: nLight proposes the development of high efficiency, high average power 1550-nm laser transmitter system that is based on Er-doped fiber amplifier resonantly pumped by high efficiency 1532-nm fiber-coupled diode laser pumps. To meet the efficiency requirement for space communication, nLight proposes… more

Compact, Rugged, Multiple Spectral Band Laser

Company: nLight Photonics Agency/Program/Year/Phase: DOD / SBIR / 2013 / 1
Abstract: nLIGHT proposes the development of a multiple spectral band laser head that is based on a vertically stacked array of single emitter laser diodes. A key design aspect of this device is that the proposed laser head is largely based on a multi-emitter pump module that is currently under commercial… more

Multi-kW Fiber Lasers Based on Novel Light Guide Combiners

Company: nLight Photonics Agency/Program/Year/Phase: DOD / SBIR / 2013 / 1
Abstract: ABSTRACT: The efficient coherent beam combination of a master oscillator power amplifier (MOPA) system requires a reduction in non-linearities of the power amplifier sections. Fiber non-linearities, such as stimulated Brillouin scattering (SBS) and stimulated Raman scattering (SRS), provide an… more