AAV Mediated Gene Transfer to the CNS for MPS I
Company: REGENX, LLC Agency/Program/Year/Phase: HHS / STTR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): Mucopolysaccharidosis type I (MPS I) is an autosomal recessive storage disease caused by the absence of a-L-iduronidase (IDUA), resulting in systemic accumulation of glycosaminoglycan (GAG) storage materials, hepatosplenomegaly, skeletal dysplasias,… more
Novel Adeno-Associated Viral Therapy for Wet Age-Related Macular Degeneration
Company: REGENX, LLC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: DESCRIPTION (provided by applicant): The overall goal of this project is to develop a novel gene-based delivery system to treat neovascular age- related macular degeneration (wet AMD), a debilitating ocular disease. AMD is the leading cause of blindness inAmericans over 60 years of age, with wet AMD… more
On-board navigation for small MAVs in ship-borne environments
Company: CENTEYE, INC. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: The goal of this effort is to build a fully on-board vision based navigation system for small micro air vehicles (SMAVs) that will allow autonomous flight and navigation in a ship-borne environment. The target platform is a hovering air vehicle of 7cm to 20cm in size with a payload capacity between… more
Developing a grower-centric online software prototype to enable vegetable producers to collect accurate and timely crop harvest information
Company: AGSQUARED, LLC Agency/Program/Year/Phase: USDA / SBIR / 2012 / 1Abstract: Consumers are now demanding more information about farm production processes and their resulting harvests. Harvest records, although difficult for farmers to capture, can contain rich product data such as grading information and macro and micronutrient content, allowing farmers to differentiate… more
Optical Fluorescence and X-Ray Computed Tomography Scanner for Small Animal In-Vi
Company: BIOSCAN, INC. Agency/Program/Year/Phase: HHS / SBIR / 2011 / 2Abstract: DESCRIPTION (provided by applicant): The overall goal of this application is to develop a quantitative in-vivo small animal imaging system for fluorescent reporter probes that fuses fluorescence light emitting computed tomography (FLECT) with X- ray computed tomography (CT). The proposed… more
A synthetic biology library for the Semantic Web
Company: CLARK AND PARSIA, LLC Agency/Program/Year/Phase: HHS / STTR / 2011 / 2Abstract: DESCRIPTION (provided by applicant): The long-term aims of this project are to improve the engineering practices of synthetic biologists, and thereby to hasten the pace of synthetic biology research. Synthetic biology is poised to make great contributions to health, medicine, energy, and the… more
Fuel Efficient Forward Operating Base (FOB)
Company: Marine Design Dynamics, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2011 / 1Abstract: Marine Design Dynamics, Inc. is pleased to propose an advanced, analytical method for the development of concepts and systems to improve energy efficiency and reduce logistics requirements to sustain USMC Forward Operating Bases (FOB). In its simplest form, our concept is to provide a capability to… more
NITRC Image Repository: A Commercial Solution to Advancing Data Sharing in Neuros
Company: TURNER CONSULTING GROUP, INC. Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1Abstract: DESCRIPTION (provided by applicant): The NIH Blueprint for Neuroscience Research is committed to implementing a ten-month initiative to create a proof-of-concept of the NITRC Image Repository (NITRC-IR). The goal of the NITRC-IR is to promote publication,indexing, and sharing of anonymized fMRI… more
A Web-based Multimedia Intervention for Head and Neck Cancer Patients
Company: TRIAD INTERACTIVE, INC. Agency/Program/Year/Phase: HHS / STTR / 2011 / 1Abstract: DESCRIPTION (provided by applicant): Treatment for head and neck squamous cell carcinoma (HNSCC) often confers considerable functional impairment. As a result, HNSCC patients experience significant decrements in quality of life, high levels of emotional distress, deteriorations in interpersonal… more
Optimizing Emergency Aftercare with Mobile Video Prescriptions
Company: HEALTHEWORKS, LLC Agency/Program/Year/Phase: HHS / STTR / 2011 / 1Abstract: DESCRIPTION (provided by applicant): healthEworks' mission is to improve discharge health education for the 100 million patients discharged from U.S. emergency departments (EDs) annually. healthEworks aims to accomplish this goal by creating and distributing Video Prescriptions - concise videos… more
Optical Fluorescence and X-Ray Computed Tomography Scanner for Small Animal In-Vi
Company: BIOSCAN, INC. Agency/Program/Year/Phase: HHS / SBIR / 2010 / 1Abstract: DESCRIPTION (provided by applicant): The overall goal of this application is to develop a quantitative in-vivo small animal imaging system for fluorescent reporter probes that fuses fluorescence light emitting computed tomography (FLECT) with X- ray comput
ed tomography (CT). The proposed… more
Scalable Production of New Generation Adeno-Associated Virus Gene Therapy Vectors
Company: REGENX, LLC Agency/Program/Year/Phase: HHS / SBIR / 2010 / 1Abstract: DESCRIPTION (provided by applicant): The overall goal of this application is to develop a scalable production system for the manufacture of an adeno- associated virus (AAV) serotype 8-based gene therapy vector bearing a human low density lipoprotein recept
or (hLDLR) transgene for the treatment of… more
Countering Cyber Terrorism through Internet Media
Company: The Rendon Group Agency/Program/Year/Phase: DOD / SBIR / 2010 / 1Abstract: This Phase I Technical Approach will provide the Government with an approach to identify, assess, and monitor the manner in which terrorist websites influence target audiences. Our approach is unique in that it applies psychological and sociological approaches to understanding the information and… more
Navy ERP Advanced Visual Reporting
Company: Maga Design Group Agency/Program/Year/Phase: DOD / SBIR / 2010 / 1Abstract: The objective of this research is to demonstrate the feasibility of developing a software toolkit to describe, define and create visual data models that can be dynamically linked into a spatial framework to facilitate more rapid understanding of complex data sets for leadership decision making. The… more
Accessible Web-Based I Can Work Application that will Enhance Community Participation and Living for Individuals with Disabilities
Company: NDI Consulting, Inc. Agency/Program/Year/Phase: ED / SBIR / 2010 / 1Abstract:
Cross-layer Queue Management and Queue-status Messages for Wireless Tactical Networks
Company: Defense Group Inc. Agency/Program/Year/Phase: DOD / SBIR / 2010 / 1Abstract: Defense Group Inc. (DGI) proposes a unique approach to Cross Layer Modeling of JTRS MANETs. Our approach integrates admission control with congestion management schema. We propose a schema of "Intelligently" dropping packets with three possibilities for improved JTRS network throughput: 1) Using a… more
A synthetic biology library for the Semantic Web
Company: CLARK AND PARSIA, LLC Agency/Program/Year/Phase: HHS / STTR / 2010 / 1Abstract: DESCRIPTION (provided by applicant): The goal of the proposed research is to determine the feasibility of, and create prototype software for, a library of reusable synthetic biology components using Semantic Web technologies OWL, RDF, SPARQL and SWRL. Thislibrary will dramatically increase the… more
Multi-Attribute Reliability and Maintainability Engineering Assessment Methodology
Company: Cognition LLC Agency/Program/Year/Phase: DOD / SBIR / 2010 / 1Abstract: While current Air Force logistics processes have served us well, and provided unparalleled support since the end of the Cold War, the need to significantly reduce costs while improving weapons system availability is essential. Senior Air Force officials have stated in numerous documents that the… more
Decision Support System Based On Collaborative-orientated System Engineering Cpabilities
Company: Cognition LLC Agency/Program/Year/Phase: DOD / SBIR / 2010 / 2Abstract: The objective of this project is to promote and realize improvements in readiness, sustainability and availability for US Air Force weapons systems and platforms. The centerpiece of Phase II is the primary set of process workflows which provide for the accomplishment of Supply Chain Management (SCM)… more
Application of Advanced Materials for High Volatility Fuel Management
Company: Marine Design Dynamics, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2010 / 2Abstract: The High Volatility Fuel Storage Module (HVF Module) prototype technology demonstrator will incorporate MDD"s Phase I preliminary design efforts with a Phase II, detailed engineering approach, to develop a unit that will support the Littoral Combat Ship (LCS) as a mission module. The HFV Module… more
Advanced Development for Defense Science and Technology
Company: SUPERIOR NANOBIOSYSTEMS Agency/Program/Year/Phase: DOD / SBIR / 2009 / 1Abstract: The objective of our proposed effort is to demonstrate the feasibility of an extremely rapid analysis of whole blood samples in non-laboratory environments using MEMS-based fabrication techniques combined with new developments in highly specific antibodies. We believe this technology will enable… more
Processing for Flexible Sensors
Company: CENTEYE, INC. Agency/Program/Year/Phase: DOD / SBIR / 2009 / 2Abstract: The overall goal of this project is to develop a flexible acuity sensor (FAS), including both hardware and software, and demonstrate its ability to acquire and track moving targets in the environment, including when the sensor itself is moving. These sensors will utilize a proprietary Centeye vision… more
Expressive Integrity Constraint Validation with OWL
Company: CLARK AND PARSIA, LLC Agency/Program/Year/Phase: DOC / SBIR / 2009 / 2Abstract: We propose to develop a commercially adequate, robust and perfomant OWL-based Integrity Constraint (IC) validation system with several innovations, including novel debugging and explanation support for data integrity errors; incremental and optimized validation of data integrity; and a unified… more
Decision Support System Based On Collaborative-orientated System Engineering Cpabilities
Company: Cognition LLC Agency/Program/Year/Phase: DOD / SBIR / 2009 / 1Abstract: While current Air Force logistics processes have served us well, and provided unparalleled support since the end of the Cold War, the need to significantly reduce costs while improving weapons system availability is essential. Senior Air Force officials have stated in numerous documents that the Air… more
Potable Water Production Module
Company: Marine Design Dynamics, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2009 / 2Abstract: The Littoral Reverse Osmosis Module (L-ROM) prototype technology demonstrator is a reverse osmosis water purification module for use in littoral and other waters having a high colloidal (inorganic and natural organic) matter. The principal challenge of this project is to design a system that will… more