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Innovative Device to Improve Safety of Preparing and Administering Chemotherapy

Company: J AND J SOLUTIONS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 2
Abstract: ? DESCRIPTION (provided by applicant): Manual drug compounding of chemotherapy medications permits deadly dosing errors and toxic drug exposure and therefore poses unnecessary risks to patients and healthcare professionals. Some robotic compounding devices have been developed in response;… more

SBIR Phase II: In Situ Optical Probe for Real-time Monitoring of Protein Expression Bioreactors

Company: ASL Analytical, Inc. Agency/Program/Year/Phase: NSF / SBIR / 2014 / 2
Abstract: This Small Business Innovation Research (SBIR) Phase II project proposes to develop an on-line, probe-based monitor for the real-time, continuous measurement of key analytes in protein expression bioreactors. This directly addresses the need for improved biopharmaceutical production monitoring. The… more

Development of a Porcine Model of Autosomal Dominant Polycystic Kidney Disease

Company: EXEMPLAR GENETICS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common, potentially fatal genetic disorders in humans with an incidence of 1 in every 500-1000 individuals. The majority of ADPKD cases (85%) are caused by mutations in the PKD1 gene, which… more

Development of a Porcine Model of Duchenne Muscular Dystrophy

Company: EXEMPLAR GENETICS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2014 / 2
Abstract: DESCRIPTION (provided by applicant): Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder caused by mutations in the DMD gene with a prevalence of 1 in 3500 male births. The consequent loss of functional dystrophin results in the progressive degeneration of skeletal and cardiac… more

Next Generation Vaccine for Infectious Bovine Keratoconjuctivitis

Company: HARRISVACCINES, INC. Agency/Program/Year/Phase: USDA / SBIR / 2014 / 1
Abstract: Currently available vaccines for infectious bovine keratoconjunctivitis (IBK), also known as "pinkeye", have poor efficacy and low cross-protection between strains. This may be partly due to the lack of mucosal antibody responses, which are not induced by traditional inactivated bacterin… more

Acoustic Array Simulation Environment System

Company: Softronics LImited Agency/Program/Year/Phase: DOD / SBIR / 2014 / 2
Abstract: The proposed effort will design and build a 64 channel ASW test/training system that relays individual sonobuoy acoustic data from a master scenario generator to each randomly located/drifting relay sonobuoy. The data is retransmitted as simulated sonobuoy data for purposes of training and testing.… more

A Computational Tool for High Advance Ratio Configurations

Company: Sukra Helitek Inc. Agency/Program/Year/Phase: NASA / SBIR / 2014 / 1
Abstract: Newer vertical lift configurations consider speed as an important design parameter with forward speeds upwards of 230 Knots, which is well above the acceptable incompressible flow regime. In such high speed vertical lift configurations, even though the aircraft may be cruising at compressible Mach… more

Targeting the chondrosarcoma extracellular matrix for drug delivery

Company: TERPENOID THERAPEUTICS, INC. Agency/Program/Year/Phase: HHS / STTR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Chondrosarcoma is the second most common primary tumor of the bone having an incidence of 8 per million people in the US population over age 80. Research, particularly on cancer of the breast, has made great strides incurtailment of disease with chemo and… more

Gamma-ketoaldehyde scavengers for alcoholic liver disease

Company: METABOLIC TECHNOLOGIES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Chronic alcohol overconsumption is the third largest risk factor for disease burden worldwide and is a frequent comorbidity of liver disease and cancer. While abstinence is a cornerstone of treatment, there is considerable interest in identifying other… more

Nutritional Intervention for Age-Related Muscular Function and Strength Losses

Company: METABOLIC TECHNOLOGIES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 2
Abstract: DESCRIPTION (provided by applicant): Sarcopenia, defined as age related loss of muscle mass and muscle function and strength, is very prevalent among the elderly. Sarcopenia is one of the largest public health problems facing a rapidly increasing, aging population in the United States and leads to… more

SBIR Phase I: Commercialization of multi-modal nanoparticle imaging contrast agents for multi-scale use in biomedical applications

Company: NanoMedTrix, LLC Agency/Program/Year/Phase: NSF / SBIR / 2014 / 1
Abstract: This Small Business Innovation Research Phase I project will demonstrate the feasibility of using an innovative multimodal imaging agent for cell tracking. While traditional contrast agents are suitable for many clinical imaging approaches, new fields of medicine, such as stem cell transplantation,… more

Unified high performance analysis of imaging biomarkers for Alzheimer's disease

Company: PIERSON BRAIN IMAGE ANALYSIS Agency/Program/Year/Phase: HHS / SBIR / 2014 / 2
Abstract: DESCRIPTION (provided by applicant): Alzheimer's disease is a neurodegenerative disease of the brain causing impairments to memory and cognitive functions, eventually leading to death. The causes of Alzheimer's disease and mechanisms of disease progressionare not fully understood, but an… more

Quantitative Test of the Success/Reduction of Harm of Smoking Cessation Treatment

Company: BEHAVIORAL DIAGNOSTICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Cigarette smoking is the most common preventable cause of morbidity and mortality in the United States. Over the past 20 years, several effective treatments, including varenicline, bupropion and nicotine replacement treatments (NRT, such as nicotine gum or… more

Development of Novel Small Molecule Therapies for Skeletal Muscle Atrophy

Company: EMMYON, INC. Agency/Program/Year/Phase: HHS / STTR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Skeletal muscle atrophy is a widespread and serious medical problem. Frequent causes of skeletal muscle atrophy include orthopedic injuries, bed rest, advanced age, cancer, heart failure, COPD, diabetes, stroke, renalfailure, critical illness and spinal cord… more

Power-Dense Lightweight Hydro Turbine/Generators for 20,000+ Low-Head US Dams and Reclamation Conduits that Install In-Line,are Low Cost and Mass Producible

Company: Amjet Turbine Systems, LLC Agency/Program/Year/Phase: DOE / SBIR / 2014 / 2
Abstract: There is a manifest need in the US and the world for renewable, lowcost energy. However, conventional and small hydropower systems for (20,000+) low head dams (550ft.) in the US tend to be extremely costintensive due to a variety of configurational issues. These include coffer dams, power houses,… more

SBIR Phase I: Novel enzymes for producing homogeneous preparations of individual, monounsaturated industrial fatty acids

Company: VariFAS Biorenewables LLC Agency/Program/Year/Phase: NSF / SBIR / 2014 / 1
Abstract: The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is the development of a new scalable manufacturing capability for producing bio-based chemicals for surfactants, lubricants, and polymers. This manufacturing platform will utilize biologically… more

Multiple-stage activated-char filtration

Company: Advanced Renewable Technology International Inc Agency/Program/Year/Phase: DOE / STTR / 2014 / 1
Abstract: Less than 1% of the worlds water is considered freshwater. Population growth and intensive use in cities and agro industrial activities threatens the depletion of this resource in many parts of the world. This depletion poses many major social and economic concerns. As a result, efforts have been… more

Reliability-Based Design Optimization Software Package for Broader Simulation-Based Design Applications

Company: RAMDO Solutions, LLC Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: It is critical to the US Army to have reliable ground vehicles that can be relied on to demonstrate consistently high levels of performance for survivability, mobility, and durability under a wide range of operational conditions without being subject to unanticipated premature failure, and with… more

The Iowa Assessment of Skills and Knowledge for Automatic Word Recognition and Decoding (iASK)

Company: FOUNDATIONS IN LEARNING, INC Agency/Program/Year/Phase: ED / SBIR / 2014 / 1
Abstract: The project team is developing a prototype of an online word recognition assessment program for middle school students who are struggling readers. The assessment will address a variety of literacy skills including decoding, fluency, and word recognition. The product will generate formative… more

Code optimization for two-dimensional distributed soil loss modeling

Company: AGREN INC Agency/Program/Year/Phase: USDA / SBIR / 2014 / 1
Abstract: Central Iowa-based small business, Agren, in collaboration with the ARS Sedimentation Laboratory and the University of Tennessee, has developed two GIS-based soil loss modeling tools. Each tool combines remotely-sensed, high-resolution digital elevation models (LiDAR) and newly developed hydrologic… more

"Cyclodextrin diets for enhancing fish health"

Company: DIAMOND V MILLS, INCORPORATED Agency/Program/Year/Phase: USDA / SBIR / 2014 / 1
Abstract: Aquaculture is the fastest growing food-producing sector in the world and accounts forapproximately 50% of the seafood consumed throughout the world. However, the demand for farmraisedfish has pushed fish production densities to new limits and this has increased the incidenceand spread of disease.… more

SBIR Phase I: A Collaborative Aerospace Vehicle Design Game in Support of Engineering Curricula for Grades 9-12

Company: VSI Aerospace, Inc. Agency/Program/Year/Phase: NSF / SBIR / 2013 / 1
Abstract: This Small Business Innovation Research (SBIR) Phase I project involves the development of the Design environment for Aerospace Vehicles in Classroom Interaction (DAVinCI). DAVinCI is a collaborative, guided inquiry environment and game targeted for grades 9-12. This concept will integrate aerospace… more

A brief iPad-based screening measure for HIV-associated neurocognitive disorders

Company: DIGITAL ARTEFACTS, LLC Agency/Program/Year/Phase: HHS / STTR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): HIV-associated neurocognitive disorders (HAND) remain prevalent despite effective anti-retroviral treatments. Cognitive impairments in the current treatment era are often mild and not readily detectable because currentscreening measures (e.g., the HIV Dementia… more

Development of a Porcine Model of Juvenile Neuronal Ceroid Lipofuscinosis

Company: EXEMPLAR GENETICS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): Juvenile neuronal ceroid lipofuscinosis (JNCL), also known as Batten disease, is an autosomal recessive disorder caused by mutations in the CLN3 gene with a worldwide incidence of 1 in 12,500 live births. It is part ofa group of lysosomal storage disorders - the… more

Internet-Based Distributed Quantitative 4D Analysis of Aortic MR/MDCT Images

Company: MEDICAL IMAGING APPLICATIONS, LLC Agency/Program/Year/Phase: HHS / STTR / 2013 / 2
Abstract: Aortic aneurysms and dissections are a cause of frequently preventable death for over 13,000 people annually in the US alone. Many more patients live under a constant threat of a catastrophic aortic event from atheroscle- rotic or congenital causes. Therefore, early and comprehensive diagnosis of… more