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Clonal Hematopoietic Progenitor Cell Assay

Company: Aastrom Biosciences, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1993 / 1
Abstract: Hematopoiesis, the regulated production of mature blood cells, is a complex scheme of multilineage differentiation which occurs mainly in the bone marrow of adult mammals. Mature cells are continuously produced from progenitor (or precursor) cells. Consequently, assays which detect these progenitor… more

Hematopoietic Cell Expansion System

Company: Aastrom Biosciences, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1993 / 1
Abstract: N/A

Improved Ultrafilters for Bioprocessing

Company: Abel Company Agency/Program/Year/Phase: HHS / SBIR / 1993 / 1
Abstract: Efficient separation and purification of bioproducts on a commercial scale are controlling steps in the bioprocessing of high value-added products such as therapeutics in human health care. This project will examine the feasibility of achieving significant improvement in downstream processing… more

LASER-ELECTRODE CATHETER FOR AV NODE-HIS BUNDLE ABLATION

Company: Abela Laser Systems Agency/Program/Year/Phase: HHS / SBIR / 1993 / 2
Abstract: ABELA LASER SYSTEMS (ALS) PLANS TO DESIGN, DEVELOP, AND CHARACTERIZE A COMBINATION LASER-ELECTRODE CATHETER FOR PERCUTANEOUS TRANSVENOUS HIS BUNDLE ABLATION. THE CATHETER WILL BE CAPABLE OF SAFELY PROJECTING A SUFFICIENT AMOUNT OF LASER ENERGY TO THE AV NODE-HIS BUNDLE TO ABLATE OR PERMANENTLY… more

Innovative Power Module

Company: Abi Agency/Program/Year/Phase: DOD / SBIR / 1993 / 1
Abstract: At the end of Phase I, ABI will deliver a working "subscale" power module which runs on diesel fuel and has an output of approximately 25 horsepower at 3600 RPM. The overall size, exclusive of fuel pump, cooling, and 011 tank, will be approximately the size and shape of a roll of kitchen paper… more

NEW FLOW CYTOMETRY TECHNOLOGIES FOR CLINICAL HEMATOLOGY

Company: ABIOMED, INC. Agency/Program/Year/Phase: HHS / SBIR / 1993 / 2
Abstract: AUTOMATED BLOOD CELL ANALYSIS IS A ROUTINE FUNCTION IN THE CLINICAL HEMATOLOGY LABORATORY. HOWEVER, THE FLOW CYTOMETRIC INSTRUMENTATION PERFORMING THESE TESTS MAY HAVE FUNDAMENTAL LIMITATIONS REGARDING MEASUREMENT OF RED BLOOD CELL VOLUME, RED BLOOD CELL HEMOGLOBIN CONCENTRATION, AND ACCURATE… more

MINIATURE IMPLANTABLE TRANSCUTANEOUS OPTICAL DATA LINK

Company: ABIOMED, INC. Agency/Program/Year/Phase: HHS / SBIR / 1993 / 2
Abstract: BETWEEN COCHLEAR IMPLANTS AND QUADRI/PARAPLEGICS, THERE ARE APPROXIMATELY 700,000 PERSONS IN THE U. S. WHO WOULD BENEFIT FROM PROSTHETICS UTILIZING NEURAL OR NEUROMUSCULAR STIMULATION. SUCH SYSTEMS REQUIRE IMPLANTABLE, HIGH-SPEED, BI-DIRECTIONAL, TRANSCUTANEOUS DATA TRANSMISSION IMMUNE TO VARIATIONS… more

Disposable High Resolution Falloposcope

Company: ABIOMED, INC. Agency/Program/Year/Phase: HHS / SBIR / 1993 / 1
Abstract: Endoscopic exploration of the utero-fallopian region is useful and may become a more general observational modality if a viewing instrument can be build with a front end that is disposable and inexpensive, has a small diameter with potential for transcervical introduction without anesthesia, and can… more

Optical Periodontal Probe

Company: ABIOMED, INC. Agency/Program/Year/Phase: HHS / SBIR / 1993 / 1
Abstract: N/A

Tubular Pediatric Ventricular Assist Device

Company: ABIOMED, INC. Agency/Program/Year/Phase: HHS / SBIR / 1993 / 1
Abstract: N/A

Self-routing Optical Crossbar Switch

Company: Abj Integration Technologies, Agency/Program/Year/Phase: DOD / SBIR / 1993 / 1
Abstract: High speed, low cost optical self routing optical crossbar switches with gigabit data rates are key components in optical communication and routing systems. We propose to fabricate and study a monolithically integrated optical crossbar switch which will be inexpensive and high performance. This… more

Field Localization Of Brain Generators

Company: ABRATECH CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 1993 / 1
Abstract: Preliminary studies have demonstrated the feasibility of a novel computational scheme which will address critical errors in the present methodology of source localization. These studies will also make it feasible to obtain source location and pattern of activity based on realistic models of the head… more

Expert Polynomial Network Turbine Engine Diagnostician

Company: ABTECH CORPORATION Agency/Program/Year/Phase: DOD / SBIR / 1993 / 1
Abstract: The objective of this effort is to demonstrate a prototype advanced diagnostic system for the T800 turboshaft engine using a hybrid polynomial network and production-rule expert system. The resulting system will demonstrate the feasibility of developing a revolutionary diagnostic capability which… more

An Ontogenic Polynomial Neural Network/Expert System Modeling Evnironment for Chaotic Avionics Systems Behavior Prediction

Company: ABTECH CORPORATION Agency/Program/Year/Phase: DOD / SBIR / 1993 / 1
Abstract: N/A

THE CONTROL INTERFACE ASSESSMENT SYSTEM

Company: ACADEMIC SOFTWARE, INC. Agency/Program/Year/Phase: HHS / SBIR / 1993 / 2
Abstract: THIS PROJECT DEVELOPS AND FIELD TESTS A PROTOTYPE SOFTWARE/HARDWARE ASSESSMENT PACKAGE TO SUPPORT ASSISTIVE TECHNOLOGY ASSESSMENT PERSONNEL RESPONSIBLE FOR SELECTION OF APPROPRIATE CONTROL INTERFACE DEVICES FOR PERSONS WHO HAVE DIFFICULTY INTERACTING WITH THEIR ENVIRONMENT. THIS POPULATION INCLUDES… more

Sports Center Unlimited

Company: ACADEMIC SOFTWARE, INC. Agency/Program/Year/Phase: HHS / SBIR / 1993 / 1
Abstract: Sports Center Unlimited will be a simulated sports/leisure activity exploration program for youths with physical disabilities. The Phase I prototype will run on a Macintosh using QuickTime multi-media with sound, color, video, animation, and user interaction. As one of many animated characters, each… more

REMOVAL OF AUTOMOTIVE POLLUTANTS USING NEW METAL-SUPPORTED METAL CATALYST

Company: Accel Catalysis Inc. Agency/Program/Year/Phase: EPA / SBIR / 1993 / 1
Abstract: A NEW TECHNIQUE IS PROPOSED FOR THE PREPARATION OF METAL-SUPPORTED METAL (MSM) CATALYSTS. THE KEY FEATURE OF THIS TECHNIQUE INVOLVES THE PREPARATION OF A THIN LAYER OF POROUS METAL ON TOP OF A METAL SUBSTRATE SUCH THAT THE POROUS METAL SURFACE IS AN INTEGRAL PART OF THE METAL SUPPORT. SUBSEQUENT… more

COMPUTERIZED EMERGENCY OPERATION PROCEDURES RESEARCH

Company: Accident Prevention Group Agency/Program/Year/Phase: NRC / SBIR / 1993 / 2
Abstract: THE PURPOSE OF PHASE I OF THIS RESEARCH PROJECT IS TO CRITICALLY REVIEW THE EXISTING COMPUTERIZED EOP SYSTEMS FOR BOTH PWR AND BWR PLANTS, DEVELOPED BY VARIOUS NATIONAL AND INTERNATIONAL ORGANIZATIONS TO FULLY UNDERSTAND THEIR ADVANTAGES, DISADVANTAGES AND LIMITATIONS IN TERMS OF THEIR IMPACT ON… more

REAL-TIME COLLECTION OF OPERATIONAL DATA TO SUPPORT RISK-BASED OPERATION REGULATION AND INSPECTIONS AT NUCLEAR POWER PLANTS

Company: Accident Prevention Group Agency/Program/Year/Phase: NRC / SBIR / 1993 / 1
Abstract: COMPUTERIZED DATA COLLECTION DEVICES EXIST AND ARE BEING USED IN VARIOUS APPLICATIONS AT SOME NPPS FOR SYSTEMS AND EQUIPMENT NOT INSTRUMENTED IN THE CONTROL ROOM. HOWEVER, CURRENT APPLICATIONS IN THE NUCLEAR POWER INDUSTRY ARE RATHER SPORADIC AND NOT EXPLOITING THE FULL POTENTIAL OF THE TECHNOLOGY.… more

ADVANCED ACCELERATORS BASED ON SUPERCONDUCTING BAND GAP STRUCTURES

Company: Accsys Technology, Inc. Agency/Program/Year/Phase: DOE / SBIR / 1993 / 2
Abstract: THIS PROJECT INVESTIGATES A NEW TYPE OF HIGH Q RESONANT STRUCTURE, WHICH HAS RECENTLY BEEN DEMONSTRATED, TO DEVELOP HIGH GRADIENT, SUPERCONDUCTING ACCELERATOR CAVITIES. BASED ON THE CONCEPT OF A PHOTONIC BAND GAP (PBG) RESONATOR, THESE NEW STRUCTURES ARE PHYSICALLY SIGNIFICANTLY DIFFERENT FROM THE… more

High Current CW Superconducting RFQ Linac

Company: Accsys Technology, Inc. Agency/Program/Year/Phase: DOD / SBIR / 1993 / 1
Abstract: THE EFFECTIVENESS OF THE NEUTRAL PARTICLE BEAM (NPB) MISSILE DEFENSE SYSTEM DEPENDS ON THE SUCCESSFUL ACCELERATION OF HIGH BRIGHTNESS H ION BEAMS AT HIGH CURRENTS WITH CONTINOUS WAVE (CW) OPERATION. PRESENT BASELINE DESIGNS FOR THESE POWERFUL LINAC SYSTEMS INCLUDE ONE OR MORE STAGES OF BEAM… more

Development of an RFQ Linear Accelerator for Clinical BNCT

Company: Accsys Technology, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1993 / 1
Abstract: The primary goal of this Phase I design study is to develop the design of an accelerator-based neutron source for clinical boron neutron capture therapy (BNCT) using the compact radio-frequency quadruple (RFQ) linear accelerator. This accelerator design study will be completed in collaboration with… more

AN EXTENDED INTERDIGITAL NIOBIUM SUPERCONDUCTING LINAC STRUCTURE FOR LOW VELOCITY HEAVY IONS

Company: Accsys Technology, Inc. Agency/Program/Year/Phase: DOE / SBIR / 1993 / 1
Abstract: THE USE OF THE RADIO FREQUENCY SUPERCONDUCTING ION LINACS HAS GROWN STEADILY OVER THE PAST 15 YEARS, PRIMARILY FOR APPLICATIONS IN NUCLEAR AND ATOMIC PHYSICS WHERE FLEXIBILITY N ION SPECIES AND ENERGY ARE REQUIRED. THIS TECHNOLOGY CONTINUES TO BE ACTIVELY DEVELOPED AT SEVERAL LABORATORIES WORLDWIDE.… more

METHODS FOR REDUCING PLASMA EFFECTS ON THE NASP

Company: Accurate Automation Corporation Agency/Program/Year/Phase: DOD / SBIR / 1993 / 2
Abstract: WE PROPOSE THE DEVELOPMENT OF AN INNOVATIVE NEUROCONTROLLER THAT GENERATES TRAJECTORIES WHICH REDUCE PLASMA EFFECTS ON THE COMMUNICATION SYSTEM OF THE NASP. WE WILL MODEL PLASMA SHEATH GENERATION AND INCORPORATE THIS MODEL INTO A GHAME FLIGHT SIMULATOR ON A SILICON GRAPHICS WORKSTATION. THIS MODEL… more

PARALLEL NEURAL NETWORK TOOLBOX FOR SUPERCOMPUTERS

Company: Accurate Automation Corporation Agency/Program/Year/Phase: DOD / SBIR / 1993 / 2
Abstract: THIS PROPOSAL INVOLVES RESEARCH INTO A SUPERCOMPUTER-BASED ENVIRONMENT FOR RESEARCH INTO MASSIVELY PARALLEL NEURAL-NETWORK ALGORITHMS FOR LARGE SCALE, COMPUTATIONALLY INTENSE PROBLEMS. THIS ENVIRONMENT WILL HAVE APPLICATION TO AREAS SUCH AS IMAGE PROCESSING, PATTERN RECOGNITION, CONTROL SIGNAL… more