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Allergens and Induced Asthma: Eradicating Indoor Allergens from Dust Mites (Phase

Company: CARBONIX, LLC Agency/Program/Year/Phase: HHS / SBIR / 2014 / 2
Abstract: DESCRIPTION (provided by applicant): The mission of CarboNix LLC is the clinically effective abatement of common indoor allergens that cause allergic reactions and frequently induce asthma, especially in economically-disadvantaged children. CarboNix LLC proposes a Phase II SBIR research program that… more

Lessons from Nature: Antifreeze Glycolipids for Cryopreservation of Mammalian Cel

Company: CELL AND TISSUE SYSTEMS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Storage of cells for many researchers simply involves addition of 10% DMSO or similar cryoprotectants to cells in suspension, putting them in cryovials and slow cooling to subzero temperaturesf and storage in a mechanical or nitrogen cooled freezer or dewar. As… more

Cryopreservation of Engineered Tissue Equivalents

Company: CELL AND TISSUE SYSTEMS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 2
Abstract: ABSTRACT In an effort to reduce the use of animals for toxicity testing, companies have developed in vitro skin models or equivalents to replace the Draize skin irritation test. This development has been further pushed by the European Union regulation thathas prohibited the use of animals for… more

A Millimeter-wave Tunable Cavity for Ultra-sensitive Solids and Liquids DNP-NMR at Low Budget

Company: DOTY SCIENTIFIC, INC. Agency/Program/Year/Phase: HHS / STTR / 2014 / 1
Abstract: ? DESCRIPTION (provided by applicant): NMR is probably the most powerful and widely used analytical technique for structure determination and function elucidation of molecules of all types, but it suffers from low sensitivity, particularly for insoluble biological macromolecules. Dynamic… more

Evaluation Of A Novel Connexin-Based Peptide For The Treatment Of Diabetic Wounds

Company: FIRSTSTRING RESEARCH, LLC Agency/Program/Year/Phase: HHS / SBIR / 2014 / 2
Abstract: Project Summary/Abstract According to the ADA, 25.8 million children and adults have diabetes. Diabetics have an increased risk of complications such as heart disease and are prone to impaired wound healing. A major cause of morbidity and hospitalizationis diabetic foot ulceration (DFUs) that may… more

Selectively Absorbable Surgical Mesh for Hernia Repair

Company: POLY-MED, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Hernia repair is one of the most frequently performed surgical operations in the United States with approximately 800,000 procedures performed annually. The vast majority of these repairs employ a tension- free repairtechnique which involves the use of… more

Low-loss Optical Polymer Materials in Multi-kilogram Quantities for Optical Lens Development

Company: Tetramer Technologies, L.L.C. Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: In this Phase I SBIR program, Tetramer Technologies will develop new, commercially attractive, thermoplastic optical polymers that have ultra-low scattering losses for use in diffraction-limited optical lenses. The value proposition to the customer using Tetramer"s optical polymers will be… more

Commercial Development of Advanced UV Curable Index Matching Materials

Company: Tetramer Technologies, L.L.C. Agency/Program/Year/Phase: DOD / SBIR / 2014 / 2
Abstract: In this Phase II SBIR program, Tetramer Technologies will develop new, commercially attractive, patentable, UV curable refractive index (RI) matching materials which have a significant shelf life in the uncured state. The value proposition to the customer working with fiber optic cabling will be… more

New Approaches to Improved PEM Electrolyzer Ion Exchange Membranes

Company: Tetramer Technologies, L.L.C. Agency/Program/Year/Phase: DOE / SBIR / 2014 / 1
Abstract: Electrolyzer systems produce high value hydrogen on demand and on site, thus eliminating costly delivery and storage cylinders of hydrogen gas. The potential commercial market applications are projected to be in the $100 billion range by 2017 and are focused in the areas of industrial gas,… more

GaN High-Power Low-Loss C3-varactor RF switch MMIC

Company: Sensor Electronic Technology, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: WWe propose to develop novel low-loss high-power fully planar GaN C3 (Capacitively-Coupled-Contact) varactor RF switch MMIC with switching time well below 300 ns. The use of GaN material system offers radical device performance improvement over MEMS, pin-diode and other switch types due to an… more

Development of a lasmiditan analogue for treatment of acute kidney injury

Company: MITOHEALTH, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): The long-term goal of this project is to develop a safe and efficacious therapeutic small molecule for treatment of acute kidney injury (AKI). AKI results from diverse insults such as sepsis, ischemia-reperfusion (I/R)or nephrotoxicant exposure and nearly half of… more

Assessing the Bite Counter as a Tool for Food Intake Monitoring: Phase II

Company: BITE TECHNOLOGIES, LLC Agency/Program/Year/Phase: HHS / STTR / 2014 / 2
Abstract: DESCRIPTION (provided by applicant): Self-monitoring has been described as the cornerstone of the behavioral treatment of obesity . Consistent self-monitoring of energy intake is associated with improved dietary adherence and weight loss and maintenance.The problem is that individuals are… more

Development of Peptide Antibiotic Nucleic Acids

Company: NUBAD, LLC Agency/Program/Year/Phase: HHS / STTR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): One of the challenges of research in infectious diseases is to find ways to use the increasing knowledge of the mechanisms underlying disease transformation and progression to develop novel therapeutic strategies for diseases such as increasing menace of… more

A Rapid Assay for RNA Targeted Drugs

Company: NUBAD, LLC Agency/Program/Year/Phase: HHS / STTR / 2014 / 2
Abstract: DESCRIPTION (provided by applicant): Some of the most significant therapies that treat disease target nucleic acids. Drugs that target nucleic acid include cancer drugs, antibiotics, and antivirals. Combined these classes of drugs have annual sales worldwide of ~ 139 billion. Antibiotics that… more

Reversal of Myocardial Infarction by Localized Stimulation

Company: MICRO VIDE, LLC Agency/Program/Year/Phase: HHS / STTR / 2014 / 2
Abstract: DESCRIPTION (provided by applicant): Heart attacks (i.e. myocardial infarction or MI) occur in more than 1.2 million patients annually. Advances in pharmacological therapy have dramatically improved survival following the initial MI. Consequently, the number of patients with previous MI continues to… more

SBIR Phase II: Computing-Assisted Zoning Optimization and Service

Company: ZillionInfo Agency/Program/Year/Phase: NSF / SBIR / 2014 / 2
Abstract: This Small Business Innovation Research (SBIR) Phase II project is aimed at developing commercial redistricting software products that can be used by non-experts. Redistricting or rezoning is the process of dividing space into districts or zones while optimizing a set of criteria under various… more

Peptide-Derived Orally-Active Kappa-Opioid Receptor Agonists for Peripheral Pain

Company: HALIMED PHARMACEUTICALS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Treatment of peripheral pain of various origins remains a major unmet medical need, affecting tens to hundreds of millions of people nationwide at some time during their lives. Kappa-opioid agonists have been shown in peripheral pain models to be particularly… more

IGF::OT::IGF SBIR Topic 314 Phase II- 3D Human Tumor Co-culture System for Accurate Prediction of Clinical Efficacy.

Company: KIYATEC, LLC Agency/Program/Year/Phase: HHS / SBIR / 2014 / 2
Abstract: Not Available

SBIR Phase I: The Multivariate Optical Element Technology Platform for Fluorochrome Discrimination

Company: Cirtemo Corporation Agency/Program/Year/Phase: NSF / SBIR / 2014 / 1
Abstract: This Small Business Innovation Research (SBIR) Phase I project proposes to develop a novel Multivariate Optical Element (MOE) technology platform for fluorescence biomarker applications with superior spectroscopic discrimination performance as compared to traditional bandpass filter techniques. Life… more

Developing the Dietary Inflammatory Index for Clinical Application

Company: CONNECTING HEALTH INNOVATIONS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): A large, persuasive, and ever-increasing body of evidence links chronic inflammation to virtually all of the chronic diseases that cause the majority of disability and death in the U.S., including diabetes, cardiovascular diseases (CVD), and cancer. Diet plays a… more

High-Power 3 Micron Fiber Based Laser System

Company: COE Optics. LLC Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: Abstract The specific goal of this SBIR effort is the development of a compact, power scalable laser source that operates 2.7 to 3 microns. The core technologies will utilize recent advancements in highly doped Er:YAG Single Crystal Fibers and integrate them into a platform that can be scaled.

SBIR Phase I: Novel Manufacturing Process for Cost-Effective Production of Discontinuous SiC Fibers from Renewable, Organic Precursors

Company: Advanced Composite Materials, LLC Agency/Program/Year/Phase: NSF / SBIR / 2014 / 1
Abstract: This Small Business Innovation Research Phase I project aims to develop a cost-effective and scalable manufacturing process for producing high performance silicon carbide (SiC) fiber for use in protective polymer coatings to increase wear resistance and extend service lifetime. The outcomes of this… more

SBIR Phase IB: Nanomanufactured optical elements for fiber optic connectors

Company: MagAssemble, LLC Agency/Program/Year/Phase: NSF / SBIR / 2014 / 1
Abstract: The broader impact/commercial potential of this project is in the field of advanced manufacturing. This project develops a low cost, high resolution nanomanufacturing technology platform for building optical fiber devices with approaches that are currently out of reach because of manufacturing cost.… more

Fabrication of T-SOFC via Freeze Cast Methods for Space and Portable Applications

Company: Yanhai Power LLC Agency/Program/Year/Phase: NASA / SBIR / 2014 / 1
Abstract: As NASA space missions become longer in duration the need for high efficiency power generator sets that can operate on NASA logistical fuel become critical. Historically NASA has used fuel cells as part of the energy solution. Space bound energy and power systems require rapid start and stop cycle… more

Engineered Neurotensin Fragments Targeting Neuropathic Pain

Company: JT PHARMACEUTICALS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Neuropathic pain management is a major unmet clinical need. Classically used medications, including opioids and non-opioids (primarily NSAIDs), have major side effects associated with their use, and many individuals donot respond to any medications. Neuropathic… more