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Intracellular Detection of Small Molecules in Live Cells

Company: Agave BioSystems, Inc. Agency/Program/Year/Phase: DOD / STTR / 2014 / 2
Abstract: ABSTRACT: Protection of first responders who are exposed to hazards including chemical warfare agents (CWAs) is a very critical need. The need is derived from not only their welfare but their ability to respond, protect the community and provide logistical support to the response. A simple… more

Identification of Patients with Clostridium Difficile Infection, Colonization and/or Reoccurrence

Company: Agave BioSystems, Inc. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: Clostridium difficile infection (CDI) results in excess of 14,000 deaths and over $1 billion in excess healthcare costs annually. Early and reliable diagnosis is key for both improving treatment outcomes, and instituting precautions to prevent transmission. Antibiotic therapy can actually increase… more

Volcanic Ash Analysis and Detection Technology

Company: Mobile Mapping Corporation Agency/Program/Year/Phase: DOD / SBIR / 2014 / 2
Abstract: ABSTRACT: Aviation near volcanic plumes is dangerous because aircraft engines can be damaged if they ingest airborne ash and aerosols. Knowing the forecast location of an ash plume will improve aviation safety while reducing engine maintenance costs. Ash forecast models are immature. To… more

Harnessing Clean River Energy with the RivGen Power System to Replace and Offset Diesel Fuel Use by Rural Communities

Company: ORPC ALASKA, LLC Agency/Program/Year/Phase: USDA / SBIR / 2014 / 2
Abstract: ORPCproposes a project that will alter fossil fuel use and energy economics in remote off-grid river communities. The project will allow conversion of hydrokinetic river energy, a vast renewable resource that is underutilized, into an economical, reliable source of clean electricity for river… more

High-capacity and Cost-effective Manufacture of Chloroperoxidase

Company: Agave BioSystems, Inc. Agency/Program/Year/Phase: DOD / STTR / 2013 / 2
Abstract: The chloroperoxidase enzyme from the filamentous fungus Caldariomyces fumago has applications in industrial chemical synthesis and the detection and inactivation of chemical warfare agents. Chloroperoxidase is capable of regio- and enantioselective oxygenations and halogenations of organic… more

Multiplex Immunoassays in the Development of Vaccines Against Enteric Pathogens

Company: Agave BioSystems, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2013 / 2
Abstract: Bacterial enteric pathogens causing travelers"diarrhea (TD) in developing countries include enterotoxigenic E. coli (50%), Camplyobacter jejuni, Shigella sonnei and Shigella flexneri, while Norovirus is a common viral cause. High risk regions for TD include areas where US service members are… more

Probiotics for Maintaining Dolphin (Tursiops truncatus) Health and the Readiness of the U.S. Navy"s Marine Mammal Systems

Company: Agave BioSystems, Inc. Agency/Program/Year/Phase: DOD / STTR / 2013 / 1
Abstract: Agave BioSystems, with their academic partners at the Mote Marine Laboratory, proposes to develop probiotic pharmaceuticals from indigenous commensal microbes to enhance gastrointestinal health in the bottlenose dolphin (Tursiops truncatus). The dolphin gastrointestinal microbiome will be… more

PNA-Based Rapidly Adaptable Anti-Microbial Nanoparticles

Company: Agave BioSystems, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2013 / 2
Abstract: Wound management becomes increasingly challenging due to bacterial infections, especially from epidemic drug-resistant strains. To address this problem, Agave BioSystems proposes to develop a RANT (Rapidly Adaptable Nanotherapeutics) breadboard system built upon the modules successfully established… more

National Phone App for Linking Adolescents to Local Pregnancy Prevention Resources

Company: National Health Promotion Asso., Inc. Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: Teen pregnancy rates remain high particularly among racial/ethnic minority youth and age of onset for sexual activity has decreased significantly in recent years. As young teenagers initiate dating and sexual activity during the years of middle school, there are often few resources available for… more

Harnessing Clean River Energy with the RivGen Power System to Replace and Offset Diesel Fuel Use by Rural Communities

Company: ORPC ALASKA, LLC Agency/Program/Year/Phase: USDA / SBIR / 2013 / 1
Abstract: This project will make hydrokinetic river energy, a completely renewable resource, into an economical source of clean power for river communities. ORPC will accomplish this by optimizing the prototype RivGen Power System design for lower speed river currents that are prvalent throughout the world.… more

Intracellular Detection of Small Molecules in Live Cells

Company: Agave BioSystems, Inc. Agency/Program/Year/Phase: DOD / STTR / 2012 / 1
Abstract: ABSTRACT: The extreme toxicity of organophosphate (OP) chemical warfare agents (CWA) is due to their specific, rapid, and irreversible reaction with cholinesterase enzymes. A significant portion of this reactive nature of OP agents is directly due to the unique metabolically active environment… more

Ionic Liquid-Based Dried Biological Specimen Materials

Company: Agave BioSystems, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1
Abstract: Dried blood spots (DBS) analysis has many advantages over standard liquid blood sample testing including: small sample size, ease of blood sampling, room temperature storage, minimal storage size requirement, and ease of shipping. Although these advantages are significant, there are still problems… more

PNA-Based Rapidly Adaptable Anti-Microbial Nanoparticles

Company: Agave BioSystems, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1
Abstract: Agave BioSystems proposed to develop a system of Rapidly Adaptable Nanotherapeutics (RANT) by combining advanced bioformatics, with DNA-based nanoparticles, peptide nucleic acid (PNA) antisense oligonucleotides, and cell permeating peptides (CPPs). Advanced bioinformatics computing will allow for… more

Combinatorial PNA-CPP Molecules Targeting Plasmid Transfer and Replication to Control Antibiotic Resistance

Company: Agave BioSystems, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1
Abstract: One major cause of the widespread of drug-resistant and virulent bacteria pathogen is the horizontal gene transfer of resistance and virulence genes in the form of plasmids. As proof-of concept for this Phase I effort, Agave BioSystems proposes to develop combinatorial therapeutics by inhibiting… more

Antimicrobial Drug Targeted to Essential Bacterial Genes in Wound Infection Pathogens

Company: Agave BioSystems, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1
Abstract: Wounds infected with drug-resistant Gram-negative bacteria can increase morbidity, hospital length of stay and cost. Among these Klebsiella pneumoniae and Pseudomonas aeruginosa have become important causes of concern in military personnel wounded in battlefield. New classes of antimicrobial agents… more

Yeast-Based High-Throughput Screens for Inhibitors of Key Flaviviral Enzymes

Company: Agave BioSystems, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1
Abstract: With no clinically approved antiviral therapy available for treatment of flavivirus infections, the development of efficient vaccines and antiviral agents for prevention and treatment of infections is an urgent health priority. A combination of structure-based in silico models, in vitro and… more

Multiplex Immunoassays in the Development of Vaccines Against Enteric Pathogens

Company: Agave BioSystems, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1
Abstract: Bacterial enteric pathogens causing travelers"diarrhea (TD) in developing countries include enterotoxigenic E. coli (50%), Camplyobacter jejuni, Shigella sonnei and Shigella flexneri, while Norovirus is a common viral cause. High risk regions for TD include areas where US service members are… more

Novel Toxicity Sensor using Genetically Engineered, Permeabilized, Freeze-Dried Bacteria

Company: Agave BioSystems, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 2
Abstract: Field testing of water samples is needed for broad and sensitive detection of toxic industrial chemicals, or TICs. The use of unicellular organisms in cell-based detection systems is particularly advantageous both because these organisms have developed a natural ability to respond to environmental… more

Improved Coupling Factor of Personal Cooling Systems

Company: Alaska Native Technologies, LLC Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1
Abstract: The Microclimate Cooling Unit will use magnetic energy to cause a temperature change in the exchanger to extract heat from the gel pack, which covers the primary area of heat loss on the human body at the neck and upper back, reducing the overall body temperature. Thermocouples will monitor the gel… more

Production Methods and Software for NIST Calibration Phantoms

Company: Sigma-K Corp. Agency/Program/Year/Phase: DOC / SBIR / 2012 / 2
Abstract: Magnetic Resonance Imaging data needs to be calibrated using a universal standard. NIST and the ISMRM SQRM committee have developed the NIST/NIST MR phantom. The group had two phantoms manufactured to their specifications and these phantoms have been imaged at numerous imaging facilities. Sigma-K… more

Volcanic Ash Analysis and Detection Technology

Company: Mobile Mapping Corporation Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1
Abstract: ABSTRACT: A refined volcanic plume model is proposed to evaluate improved forecasting of ash movement and dispersion. This refined model utilizes near real-time model calibration and validation, perspective satellite observation geometry, and future in-situ measurements for more accurate models… more

Volcanic Ash Analysis and Detection Technology

Company: Polartronix Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1
Abstract: ABSTRACT: This proposal is to design an instrument that will detect and quantify volcanic ash hazards. A proof of concept model of the instrument will be constructed and tested. This instrument will measure overall density, particle size distribution and elemental composition. While the… more

High-capacity and Cost-effective Manufacture of Chloroperoxidase

Company: Agave BioSystems, Inc. Agency/Program/Year/Phase: DOD / STTR / 2011 / 1
Abstract: The chloroperoxidase enzyme from the filamentous fungus Caldariomyces fumago has applications in industrial chemical synthesis and the detection and inactivation of chemical warfare agents. Chloroperoxidase is capable of regio- and enantioselective oxygenations and halogenations of organic… more

Specific Epigenetic Molecules Involved in Wound Healing and Repair

Company: Agave BioSystems, Inc. Agency/Program/Year/Phase: DOD / STTR / 2011 / 1
Abstract: The ability to direct the wound pathways following injury could provide a critical path in wound care at crucial times during the progression of healing. A promising field of study in wound healing is epigenetics; alterations in gene expression caused by mechanisms other than changes in DNA… more

Multiplex Microsphere Assay for Botulinum Neutralizing Antibodies

Company: Agave BioSystems, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2011 / 1
Abstract: Currently, the accepted standard experimental model for measuring protective efficacy against botulism is the Mouse Lethality Neutralization (MLN) assay. Botulism poisoning is a life threatening condition that is not only a public health concern, but could also be a potential biological weapon. … more