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Manufacturing of Growth Factors to Enable Cardiopoietic Stem Cell Therapy for Hea

Company: APT THERAPEUTICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Cardiopoietic cell therapy significantly improved left ventricular function, blunted pathological remodeling, and functional outcomes in animal models and Phase I/II clinical trial of heart failure patients. There is ongoing Phase III trial. In this therapeutic… more

Low-dose IL2-based Immunomodulatory therapy for Stroke

Company: APT THERAPEUTICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): It has been recently shown that CD4+ and CD8+ T lymphocytes are critically involved in the collateral brain injury and neurological deficit associated with experimental stroke. Naturally occurring CD4+CD25+Foxp3+ (nTreg) cells derived from thymus play a key role… more

Next-Generation Micro-chip Carrier for Cooling of Satellite Payload Electronics

Company: ThermAvant Technologies, LLC Agency/Program/Year/Phase: DOD / SBIR / 2014 / 2
Abstract: ABSTRACT: A chip carrier for high power density electronics made from low CTE materials and embedded with an oscillating heat pipe will be applied to a real world satellite electronics device to transform high heat flux (e.g. 100-300W/cm2) at the device package to a lower heat flux at the heat sink… more

Image Quality Indicator(s) and Software for Computed Radiography (CR)

Company: Lickenbrock Technologies LLC Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: ABSTRACT: This Phase I project will be a feasibility study to develop a standard method, new image quality indicators (IQI"s) and software algorithms to automatically verify computed radiography (CR) image quality for nondestructive testing (NDT) of military airframes. Compared to existing… more

Multimodal-Multidimensional image fusion for morphological and functional evaluation of the retina

Company: Lickenbrock Technologies LLC Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: ABSTRACT: This project will deliver software that integrates information from repeated experiments, disparate imaging and functional sensing to study the physiological response of ocular tissue to laser damage. Imaging and functional testing modalities include the fundus camera, scanning laser… more

Direct RT-PCR detection of RNA pathogens in crude samples

Company: DNA POLYMERASE TECHNOLOGY, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 2
Abstract: DESCRIPTION (provided by applicant): The objective of this application is to introduce a novel, simplified, low cost technology to address the broad need of detecting RNA pathogens directly in crude samples, such as blood. Traditional RT-PCR requires purifying the RNA which increases the cost, time,… more

Efficient shaping or reshaping of complex 3D parts using engineered residual stress

Company: Engineering Software Research & Development, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: ABSTRACT: Increasing emphasis on affordability of military systems has led to a number of advances in airframe production. For example, high speed machining (HSM) has made it possible to fabricate thin structures that provide improved performance. However, near-surface plastic strains induced by… more

Development of Iron Phosphate Wasteforms for Fission Products Waste Streams

Company: MO-SCI Corp. Agency/Program/Year/Phase: DOE / SBIR / 2014 / 1
Abstract: Most liquid high-level nuclear waste is currently being immobilized to a solid form as a borosilicate glass by vitrification. However, many nuclear wastes have complex and diverse chemical compositions that reduce their compatibility with borosilicate glass. The current baseline spent nuclear fuel… more

Development of Cost-Effective YSZ Coating Methods for SOFC Interconnects

Company: MO-SCI Corp. Agency/Program/Year/Phase: DOE / STTR / 2014 / 1
Abstract: Solid oxide fuel cells (SOFCs) require robust seals that can prevent intermixing of air and fuel, remain inert in reducing and oxidizing environments while in contact with SOFC materials, and maintain their effectiveness through repeated thermal cycles. Recent research has focused on compliant (or… more

Development of Hermetic Sealing Glasses for Solid Oxide Fuel Cells

Company: MO-SCI Corp. Agency/Program/Year/Phase: NASA / SBIR / 2014 / 1
Abstract: Sealing glasses, either rigid glass-ceramics or viscous, non-crystallizing compositions, will be developed and sealing processes will be optimized based on NASA's solid oxide fuel cell (SOFC) designs. SOFC design constraints, including material selection and operational conditions, will guide… more

MIST System for Simultaneous Parallel Intracellular Delivery and Transfection

Company: OPENCELL TECHNOLOGIES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 2
Abstract: DESCRIPTION (provided by applicant): Alternative nanomaterial and gene transfer solutions are needed to access the potential held in intracellular imaging, biopharmaceuticals, gene therapy and stem cell research. Delivery of smalland macromolecules- including nucleic … more

Adjoint-Based Shape Optimization for Noise Reduction

Company: Innovative Technology Applications Co., L. L. C. Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: ITAC and its partners propose to develop and demonstrate a computational technology and methodology tool for the concurrent automated shaping of aft airframe and nozzle geometries to reduce tactical aircraft jet noise without any performance penalties. The proposed technologies will lead to an… more

Plasma Fairings for Quieting Aircraft Landing Gear Noise

Company: Innovative Technology Applications Co., L. L. C. Agency/Program/Year/Phase: NASA / SBIR / 2014 / 2
Abstract: This Phase II SBIR project deals with the design, development, and testing of a "Plasma Fairing" to reduce noise on the Gulfstream G550 landing gear. The plasma fairing will use single dielectric barrier discharge (SDBD) plasma actuators to reduce flow- separations and impingement around… more

Multi-Pulse Single Shot Explosive Power Supplies

Company: Loki, Incorporated Agency/Program/Year/Phase: DOD / SBIR / 2014 / 2
Abstract: The objective of all Phases of Loki"s current and proposed research and development work under Topic A12-064, Multi-Pulse Single Shot Explosive Power Supplies is to create new types of compact, autonomous multi-pulse single-shot power supplies that are capable of producing a series of high… more

Developing a standardized kit and normal reference profile for circular RNAs in the nervous system

Company: COFACTOR GENOMICS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Modified ribonucleic acids (RNA) are important regulators of translation and other cellular pathways. Non- coding RNAs like microRNAs play significant roles in neuronal development, and can serve as biomarkers for psychiatric disorders. Another such modified RNA… more

SBIR Phase II: Palatal Device Providing In-situ Sensory Feedback for Patients with Vestibular Imbalance

Company: Innervo Technology LLC Agency/Program/Year/Phase: NSF / SBIR / 2014 / 2
Abstract: This Small Business Innovation Research (SBIR) Phase II project proposes to develop advanced versions of a hidden and noninvasive balance device that can be used for balance assistance for people with vestibular dysfunction. Vestibular patients experience imbalance due to loss of vestibular feedback… more

SBIR Phase I: Practical On-Machine Inspection Equipment (PROMISE) for Metal Deposition Processes

Company: PRODUCT INNOVATION AND ENGINEERING, LLC Agency/Program/Year/Phase: NSF / SBIR / 2014 / 1
Abstract: This Small Business Innovation Research (SBIR) Phase I project will research and develop an innovative Practical On-Machine Inspection Equipment (PROMISE) for metal deposition processes. PROMISE will be a cost-effective and robust in-situ inspection system for direct metal deposition processes.… more

SBIR Phase II: A Knowledge-Based System to Improve Student Advisement in Two Year Colleges

Company: Townsend Communications, Inc Agency/Program/Year/Phase: NSF / SBIR / 2014 / 2
Abstract: This SBIR Phase II project is designed to improve academic advising and access to advising to over 11 million community college students. Community colleges serve a significant population of non-traditional adult students seeking associates degrees and vocational training to improve their job and… more

Development of TAK1 Compounds for Neonatal Onset Multisystem Inflammatory Disease

Company: CONFLUENCE LIFE SCIENCES, LLC Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Cryopyrin-associated periodic syndromes (CAPS) are a family of rare autoinflammatory diseases of which neonatal-onset multisystem inflammatory disease (NOMID) is the most severe phenotype. NOMID is characterized by NLRP3 activating mutations resulting in… more

Novel Inhaled Therapy for Idiopathic Pulmonary Fibrosis

Company: ANTEGRIN THERAPEUTICS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Idiopathic pulmonary fibrosis (IPF) is a deadly lung disease that affects an estimated 133,000 patients in the U.S. and more than 5 million worldwide. Median survival time after diagnosis is only 2-3 years, with a 5-year mortality rate exceeding 50%. IPF is the… more

A new two-drug combination therapy for noise-induced hearing loss

Company: GATEWAY BIOTECHNOLOGY, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Noise is the most common occupational and environmental hazard, thus it is not surprising that noise-induced hearing loss (NIHL) is the second most common form of sensorineural hearing deficit, second only to age-related hearing loss (presbycusis). Although… more

Development of Anti-Microbial Peptide Therapeutics

Company: TENSIVE CONTROLS, INC. Agency/Program/Year/Phase: USDA / SBIR / 2014 / 1
Abstract: A safe food supply is critical to the well being of any society. However, in highly urbanized societies, the number of people affected by a contaminated food source can be huge. Antibiotic resistant disease in the U.S. is an escalating problem [2, 3]. Much of this problem is a result of the use of… more

SBIR Phase II: Securing Industrial Control Networks with Network Forecasting

Company: Observable Networks, Inc Agency/Program/Year/Phase: NSF / SBIR / 2014 / 2
Abstract: This Small Business Innovation Research Phase II project is focused on network forecasting, a new approach to securing industrial control networks. In essence, network forecasting involves monitoring all devices on a network, and for each device using past behavior to predict near-term future… more

Expanding small molecule functional metagenomics through shuttle BAC expression i

Company: INTACT GENOMICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 2
Abstract: DESCRIPTION (provided by applicant): Hospital acquired microbial infections are the fourth largest killer in America, taking 100,000 lives and adding 30B to hospital costs. The emergence of drug resistant microbes has further amplified public health concern. Fungi are prolific producers of… more

Tiptuximab Immunotherapeutic for Cancer

Company: MEDICAL GUIDANCE SYSTEMS, LLC Agency/Program/Year/Phase: HHS / STTR / 2014 / 1
Abstract: ? DESCRIPTION (provided by applicant): Poor prognosis cancers such as lung cancer, glioblastoma, pancreatic cancer and others have 3 year survival rates that range from 1%-15%. Recent advancements in the development of therapeutic antibodies haveshown promise in other cancers such as breast… more