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Multi-day Pain Management Therapy with Novel Injectable Formulation

Company: ORBIS BIOSCIENCES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): Our long term goal is to widespread the use of PPF technology for promoting effective production of drug-encapsulating microparticles with uniform size and physical characteristics that can be leveraged to release a specific drug at controlled rates over… more

SBIR TOPIC 294 PHASE I - DEVELOPMENT OF GLYCOSYLATION - SPECIFIC RESEARCH

Company: APTAKON, INC. Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: The function of many cancer related proteins is modulated by modifications such as phosphorylation and glycosylation. The development of antibodies that recognize site-specific phosphorylation has vastly improved our understanding of signal transductionand cancer cell physiology and regulation.… more

Multi-view, Photon Counting DXA Scanner for Quantitative Musculoskeletal Imaging

Company: QUANTUM MEDICAL METRICS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): The fragility of osteoporotic bones is largely due to alterations in the underlying structural geometry. Research has demonstrated that it is possible to measure the mechanical geometry of human bones in vivo using dualenergy x-ray absorptiometry (DXA) scans.… more

Nanoporous Membranes for cellular microarrays and in vitro assays

Company: SIMPORE, INC. Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): Advances in protein and DNA microarrays have enabled dramatic increases in throughput and equipment standardization has made these techniques more commonplace. High density, high throughput microarrays reduce the cost of research and development in drug discovery… more

Microfabricated porous TEM grids for improved phase contrast and CryoEM imaging

Company: SIMPORE, INC. Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): Cryo electron microscopy is a powerful technique for generating 3-D images of macromolecules and their interactions with fine structure within cells. These materials are imbedded in their native state within a thin layer of amorphous ice for imaging in a… more

A Human Fc Bifunctional Fusion Protein to Treat Severe Allergic Asthma

Company: TUNITAS THERAPEUTICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): The overall goal of this proposal is to develop and commercialize a novel biologic therapy for the treatment of allergic disease and particularly allergic asthma. Specifically, this proposal will provide the critical immunogenicity, mechanistic and biomarker data… more

Ading color to cancer, adenovirus and flow cytometry to identify and capture CTCs

Company: NANOSORT, LLC Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): We propose a novel technique to identify and capture circulating tumor cells (CTCs) using engineered adenoviruses and sophisticated flow cytometry. Current techniques for detection of CTCs include reverse transcriptase-polymerase chain reaction (RT-PCR), flow… more

Lab-on-a-chip Flow Cytometer Using COlor-Space-Time (COST) Coding Method

Company: NANOSORT, LLC Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): Lab-on-a-chip flow cytometer using color-space-time (CoST) coding method NanoSort, LLC RESEARCH and RELATED Other Project Information 7. PROJECT SUMMARY Fluorescence-activated-cell-sorting (FACS) or flow cytometry enables clinicians and researchers to… more

TAS::75 0849::TAS PHASE I, TOPIC 293, CTC LABEL AND CAPTURE BY LAB-ON-A-CHIP FLOW-CYTOMETRY

Company: NANOSORT, LLC Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: This Phase I, SBIR contract is for the development of a customized lab-on-a-chip fluorescense activated cell sorter (FACS) system that will provide on-chip antibody labeling, enumeration, and sorting of CTCs suitable for downstream molecular analysis. Theaim is to further understand cancer biology… more

Mindfulness and Acceptance Applied in Colleges Through Web-Based Guided Self-Help

Company: CONTEXTUAL CHANGE, LLC Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): Nearly half of all college students have a diagnosable mental health problem (Blanco et al., 2008). College counseling centers (CCCs) are faced with increasing demands for services from Universities, students and parents to meet the treatment needs of their… more

Biased Agonism In GPCR Drug Discovery: Application To Somatostatin Agonists

Company: CRINETICS PHARMACEUTICALS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): Analogs of the neuropeptide somatostatin are important therapeutics for the treatment of hormone secreting tumors with annual sales in excess of 1.3B. However, currently available peptide depots are only effective in approximately half the patients with growth… more

Prevention of Allergic Rhinitis with Topical Immunomodulating Antibodies

Company: RADIX THERAPEUTICS, LLC Agency/Program/Year/Phase: HHS / STTR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): Up to 30% of the US population are now affected by nasal allergy, resulting in a total (direct and indirect) cost of approximately 14.6 billion per year. Seasonal allergic rhinitis (AR), due to exposure to airborne pollen and molds is a major component of this… more

TAS::75 0849::TAS

Company: RADIX THERAPEUTICS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: Over 60% of cancer patients are treated with radiotherapy, yet radiation-induced normal tissue damage can cause organ dysfunction and morbidity. Radiotherapy of CNS tumors is problematic due to potential for diminished neurological function or mental retardation. Our proprietary thrombin-derived… more

DBillScan: A Camera Phone Based Currency Reader for the Visually Impaired

Company: Limaging, LLC Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): For this SBIR Limaging, LLC teams with researchers in Ophthalmology at the Wilmer Eye Institute at Johns Hopkins University to develop DBillScan, a camera phone based currency reader to identify U.S. dollar bills for the blind and visual impaired (VI). In many… more

Stroke Treatment by Chemically-Induced Hypothermia

Company: HALIMED PHARMACEUTICALS, INC. Agency/Program/Year/Phase: HHS / STTR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): Stroke is the third leading cause of death in the United States. In spite of intensive investigations, clinical therapies for treating acute stroke patients remain limited and unsatisfactory. There are consistent animal and human data that mild to moderate… more

Development and Commercialization of Next Generation of Neural Microelectrode Arr

Company: BLACKROCK MICROSYSTEMS Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): The array technology developed by Normann et.al. two decades ago at the University of Utah is currently being manufactured and marketed to the neuroscience research community by Blackrock Microsystems (formerly known asCyberkinetics, Inc., CKI). The Utah… more

A novel ion source for efficient coupling of liquid chromatography and mass spect

Company: Masstech, Inc. Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): The primary objective of this proposal is to develop a novel ion source for the efficient on-line coupling of a wide array of chromatographic techniques with mass spectrometry. The use of liquid chromatography separation is a prerequisite for high-throughput mass… more

Vision Impaired Wayfinding with Doppler Velocimeter

Company: KORONIS BIOMEDICAL TECHNOLOGIES CORPORAT Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): The objective is to use a new innovative sensor technology called a Doppler velocimeter (DV) for solving the problem of wayfinding indoors for the vision impaired. By performing a Doppler measurement of the floor movement relative to the walking person it is… more

Home Based Spirometer for Monitoring Lung Transplant Patients

Company: KORONIS BIOMEDICAL TECHNOLOGIES CORPORAT Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): Koronis Biomedical Technologies Corporation (KBT) proposes to develop a spirometer device targeted toward the needs of lung transplantation patients. Spirometers are standard care for the management of post-operative lung transplantation patients due to their… more

A Low Power Wireless Pulse Oximeter Sensor for Unobtrusive Wearable Applications

Company: KORONIS BIOMEDICAL TECHNOLOGIES CORPORAT Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): Koronis Biomedical Technology Corporation (KBT) proposes to develop and evaluate a miniature ultralow power pulse oximeter for long-term wearable monitoring. There continues to be a clinical need for an unobtrusive pulse oximeter sensor that is small and can be… more

Allergens and Induced Asthma: Eradicating Indoor Allergens and Dust Mites

Company: CARBONIX, LLC Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): Allergens and Induced Asthma: Eradicating Indoor Allergens and Dust Mites The mission of CarboNix LLC is the clinically effective abatement of common indoor allergens that cause allergic reactions and frequently induceasthma, especially in children. The focus of… more

Novel Method and Self Contained System for Reliable Assessment of Potency of Botu

Company: AGRI-ANALYSIS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): To meet Agency requirement for reliable assessment of botulinum neuron toxin A (BoNT/A) in manufactured products, we propose to apply the fluorescent peptide beacon technology for measurement of both binding function and proteolytic function of the toxin in a… more

Microtechnology-Enhanced Surgical Device For Pediatric Lens Capsulotomy And Treat

Company: MYNOSYS CELLULAR DEVICES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): We propose a new interventional device that solves a significant therapeutic bottleneck in the treatment of lens cataract in children. As the leading cause of childhood blindness, lens cataract interferes with the optical performance of the eye and if untreated,… more

Development of tools to modify globin gene expression in stem cells

Company: RETROTHERAPY, LLC Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): Development of tools to modify globin gene expression in stem cells The objective of this proposal is to develop a treatment for patients with sickle cell disease. The development of methods for treating common geneticdiseases, such as sickle cell disease remains… more

Correlating TCR diversity to immune reconstitution after cord blood transplant

Company: ADAPTIVE TCR CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): The goal of this Phase I project is to develop a method to objectively measure immune reconstitution following hematopoietic stem cell transplantation using direct sequencing of the T-cell repertoire. This method willbe developed using data from patients treated… more