Ion Channel Drug Discovery Using Photoswitch Technology
Company: PHOTOSWITCH BIOSCIENCES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2Abstract: …st commercial products to be developed will be all-optical ion channel assays and instruments for high- throughput ion channel drug discovery. The use of all-optical technology for ion channel assays has several advantages over existing techniques: (1) Elimination of liquid… more
SBIR Phase II: Mixed Oxide Sulfur-Tolerant Water Gas Shift Catalysts
Company: PH Matter, LLC Agency/Program/Year/Phase: NSF / SBIR / 2012 / 2Abstract: This Small Business Innovation Research Phase II project will focus on the refinement of catalyst compositions identified during the Phase I program for production of fuels from biomass. New catalyst materials are needed to make liquid fuels and hydrogen from biomass more… more
SBIR Phase II: Fluid submersion cooling for energy and cost efficient data centers
Company: GR Cooling Agency/Program/Year/Phase: NSF / SBIR / 2012 / 2Abstract: This Small Business Innovation Research Phase II project proposes to commercialize liquid submersion cooling for computer servers. Liquid submersion cooling involves submersion of heat-generating components in a non-electrically-conductive liquid, replacing air as the heat… more
SBIR Phase I: Optoelectronic Solar Tracking Device
Company: Meridian Deployment Agency/Program/Year/Phase: NSF / SBIR / 2012 / 1Abstract: This Small Business Innovation Research (SBIR) Phase I project investigates a novel optical element (OE) that uses liquid crystal (LC) in thin panels to steer sunlight. Any technology using focused sunlight must account for the motion of the sun. For decades this has been… more
Persistent Anchorless Active Sonar Craft (PAASC)
Company: Liquid Robotics, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: The Liquid Robotics Team proposed to adapt LRI's wave-based propulsion technology and AD & D, Inc. and Ultra USSI's DWADS sonar technologies to create a Persistent Anchorless Active Sonar Craft. Using a combination of conventional fossil fuel and wave-based… more
Multi-Vehicle Coordinated Autonomy System for SHARC USV
Company: Liquid Robotics, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 2Abstract: The primary objective of our proposed Phase II effort is to develop a centralized multi-vehicle coordinated autonomy framework for the control of large numbers (10"s to 100"s) of SHARC (or other) unmanned surface vehicles to enable execution of several military, commercial, and science… more
Innovative Device to Improve Safety of Preparing and Administering Chemotherapy
Company: J AND J SOLUTIONS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2Abstract: … exposure to these highly toxic drugs presents serious health risks (e.g., cancers, infertility, miscarriages, birth defects, spontaneous abortions, and congenital malformations) to over 5.5 million healthcare workers who are exposed to chemotherapy drugs each year. Liquid,… more
SBIR Phase I: Economic Feasibility of ABFX Process
Company: ENVIRONMENTAL ENERGY & ENGINEERING COMPANY Agency/Program/Year/Phase: NSF / SBIR / 2012 / 1Abstract: …riven by waste heat. The broader impact/commercial potential of this project will be the adoption of an economical process for the efficient extraction of energy and chemical resources from biomass. The pretreatment process will be used for the production of liquid and gaseous… more
Antimicrobial Combinations that Help Protect Against Salmonella spp.&L. monocytogenes in Organic&Natural Poultry Products
Company: SEA STAR INTERNATIONAL, LLC Agency/Program/Year/Phase: USDA / SBIR / 2012 / 2Abstract: … in the Commercialization Plan. This proposal will add-value to agricultural wastes currently being burned as cheap fuel sources by upgrading thes waste product to food grade antimicrobials. We will do this in a sustainable manner that minimizes or eliminates most of the liquid… more
SBIR Phase I: New Chitin/Alginate Biocomposites by Homogeneous Processing in Ionic Liquids: Disruptive Technology for Wound Care Application
Company: 525 Solutions, Inc. Agency/Program/Year/Phase: NSF / SBIR / 2012 / 1Abstract: This Small Business Technology Transfer (SBIR) Phase I project will utilize patent pending technology that allows direct dissolution and reconstitution of natural biopolymers to prepare chitin/alginate composite fibers with embedded additives for use in wound care products. The technology allows for… more
Liquid and Full Pressure Range Gas Environmental TEM Specimen Holders for High-Resolution Elemental Analysis
Company: Hummingbird Precision Machine Inc. Agency/Program/Year/Phase: DOE / SBIR / 2012 / 1Abstract: The inability to dynamically image solid-state materials at atomic resolutions and perform spectroscopy at the same time in changing liquid and gas environments is a significant impediment to the advance of multiple areas of science. Recently Hummingbird Scientific has developed… more
Clinical Development of a Stable Glucagon Formulation for Bi-hormonal Pump
Company: XERIS PHARMACEUTICALS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: … and in type 1 diabetics. The major clinical metric for thisstudy will be the capacity of this glucagon formulation to raise glucose levels even after short-term aging in a patch pump chamber. The initial effort of this project will develop and optimize a non-aqueous, liquid… more
Lab-on-a-Chip for Multiplexed Newborn Screening of Lysosomal Storage Disorders
Company: Advanced Liquid Logic, Inc. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2Abstract: … screening, but when applied to enzyme assays it is expensive, time consuming, and labor intensive. There is a need for an inexpensive, rapid, and automated technology for performing newborn screening assays. A digital microfluidic cartridge, which is essentially a liquid… more
Multiplex platform for point of care newborn screening of hyperbilirubinemia
Company: Advanced Liquid Logic, Inc. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: … times of at least 3 days is not suitable for universal bilirubin screening. Therefore, there is an immediate need to develop novel point of care technologies that will meet the AmericanAcademy of Pediatrics recommendation for bilirubin screening. Advanced Liquid… more
Development of a Novel Aerosol Mass Spectrometric Technology for Rapid and Sensit
Company: Aerodyne Research, Inc. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1Abstract: …n with high resolution aerosol mass spectrometry to allow sensitive detection and chemical characterization of specific toxicants as well as toxicant classes in microvolumes of blood or biofluid samples. A droplet-on- demand (DOD) interface will convert microvolumes of liquids… more
Ionic Liquid-Based Dried Biological Specimen Materials
Company: Agave BioSystems, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: Dried blood spots (DBS) analysis has many advantages over standard liquid blood sample testing including: small sample size, ease of blood sampling, room temperature storage, minimal storage size requirement, and ease of shipping. Although these advantages are significant, there… more
A new, rapidly dissolving and thermally stable dry powder Hepatitis-B vaccine
Company: AKTIV-DRY, LLC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2Abstract: …he Phase I SBIR we tested in vitro three Hep-B dry powder formulations of commercially available Shanvac-B and demonstrated powder stability and immunogenicity at temperatures ranging from -20 ?C through 65 oC. At these temperature extremes the currently marketed liquid Hepatis… more
Highly Efficient Water Management System for Lignocellulosic Biomass
Company: Altex Technologies Corporation Agency/Program/Year/Phase: EPA / SBIR / 2012 / 1Abstract: … environmental problems. This high moisture content also increases the cost of transporting biomass from the field to a biorefinery. In the Altex process, the moisture is removed by conditioning the biomass and facilitating the removal of bound water as liquid water rather… more
Confined Submerged Jet Enhancement of Regenerative Cooling Heat Transfer Coefficients in Liquid Rocket Engines
Company: Analytical Services, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: ABSTRACT: In the proposed effort, ASI will demonstrate the feasibility of a practical, proven method for significantly increasing the heat transfer coefficient inside regenerative cooling channels. The technique, used in the electronics industry for high heat flux removal applications, requires… more
Mixed-Phase Ice Crystal and Droplet Characterization and Thermometry
Company: Artium Technologies, Inc. Agency/Program/Year/Phase: NASA / SBIR / 2012 / 1Abstract: This effort proposes to design, build, and demonstrate a new instrument for icing research and flight safety capable of discriminating liquid water from ice while simultaneously measuring the diameter, velocity, and temperature of droplets or the velocity and size for ice… more
Spatially and Temporally Resolved Imaging of Dense Sprays
Company: Artium Technologies, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: … and measurements into the depths of spray formation and dynamical processes in dense spray environments. From a phenomenological and physical point of view, it is evident that we must observe and understand the entire spray flow field including how the liquid breaks up to… more
High Turndown Ratio, High Delta-Emittance, Variable Emissivity Electrochromics
Company: Ashwin-Ushas Corporation, Inc. Agency/Program/Year/Phase: NASA / SBIR / 2012 / 2Abstract: … electrostatics, phase change materials, others), especially, e.g., for missions in extreme light/dark environments, planetary platforms. This firm's unique, patented variable-emittance skin technology, based on conducting polymers, microporous membranes and ionic liquids,… more
Very-Wide-Operating-Temperature Li Batteries Based on Unique Ionic Liquid Electrolytes Originally Developed for Electrochromics in Spacecraft Thermal
Company: Ashwin-Ushas Corporation, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 2Abstract: … beset with performance deficiencies at low/high temperatures/extreme environments (high vacuum, radiation, vibration/shock), primarily from poor conductivity/mobility in organic electrolytes used under such conditions. In this respect, electrolytes using ionic liquids, with… more
Functionalized-Conducting-Polymer - Microporous-Membrane Based Voltammetric Sensor Skins With High Selectivity/Sensitivity, Multiple Analyte Sensing i
Company: Ashwin-Ushas Corporation, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 2Abstract: A new, very inexpensive, lightweight (25 mg/cm^2), low power (micro-W/cm^2), electrochemical voltammetric sensor technology for CW agents, based on unique conducting polymer microporous membranes and ionic liquid electrolytes with very wide operating temperature, is offered.… more
Improved Coupling Factor of Personal Cooling Systems
Company: Aspen Systems, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2012 / 1Abstract: …ooled water through flow channels in a wearable vest to facilitate improved cooling of personnel in high-temperature environments. The system is designed to cycle coolant delivered to various zones within the vest enabling the body surface to vasodilate in between chilled … more