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Development of Technologies that Address the Complex Architecture of the Face During the Treatment of Severe Facial Burn Injury

Company: KeraNetics, LLC Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: …ovative 3D printed halofuginone eluding keratin-based wound dressing that could potentially improve healing rates and reduce scarring and contracture in our burned Wounded Warriors. The proposed dressing will be formulated and tested for mechanical properties and drug delivery… more

High Specific Activity Sn-117m by Post Irradiation Isotope Separation

Company: IsoTherapeutics Group LLC Agency/Program/Year/Phase: DOE / SBIR / 2014 / 1
Abstract: … of interest in a variety of biomedical applications, including several in the fields of oncology and cardiology. While tin-117m can be produced through a variety of methods, there are limiting factors that must be addressed in order to facilitate drug… more

HERMES-Based X-Ray Strip Detector

Company: Sydor Instruments, LLC Agency/Program/Year/Phase: DOE / SBIR / 2014 / 2
Abstract: … as compared to present techniques. By acquiring data simultaneously at many points, the quality and quantity of data will be improved 100-fold from the current state of the art. These detectors will benefit a wide range of applications ranging from structure-based drug… more

Fast-Timing Large-Area Detector for Neutron Scattering

Company: Radiation Monitoring Devices, Inc. Agency/Program/Year/Phase: DOE / SBIR / 2014 / 1
Abstract: … to homeland security, nuclear and high-energy physics research, and the development of new sources to effectively address our nations future energy needs. The proposed detectors will also result in scientific research leading to the development of new drugs,… more

new SPM platform for heated probe AFM and Mass Spectrometry for naNoscale chemical analysis

Company: Anasys Instruments Corp Agency/Program/Year/Phase: DOE / SBIR / 2014 / 1
Abstract: … a MS. Mass spectrometry (MS) is one of the most widely used analytical techniques for chemical characterization. It is used routinely in a wide variety of industrial and academic laboratories in a wide set of applications such as polymers, pharmaceutics, life… more

UV IR Image Combiner

Company: Physical Optics Corporation Agency/Program/Year/Phase: DOD / SBIR / 2014 / 2
Abstract: … structures and biological tissue, industrial inspection equipment for product verification and test, laser machining and drilling, microlithography, tissue welding and wideband imaging systems. Potential customers include aerospace, biomedical, pharmaceuticals,… more

A New Nb3Sn Process with a Novel Artificial Pinning Center for High Energy Physics and High Magnetic Field Applications

Company: Supramagnetics, Inc. Agency/Program/Year/Phase: DOE / SBIR / 2014 / 2
Abstract: … to 18T range. NMR spectroscopy is a non- destructive technique for mapping molecular structures and learning how molecules function and relate to each other. This is important for many applications that have benefits to the public including discovering new drugs, evaluating… more

Forensic Storage Bags for Radioactively Contaminated Samples

Company: Materials Modification Inc Agency/Program/Year/Phase: DOE / SBIR / 2014 / 1
Abstract: … disturb the chemistry of the TNF samples collected. Commercial Applications and Other Benefits: The technology as developed can be extended to many other applications, such as low-level radioactive waste storage, radioactive material transport, chemotherapy-drug… more

Low Z Thin Film Stripper Foils, Targets and X-Ray Windows

Company: UHV TechNologies, Inc. Agency/Program/Year/Phase: DOE / SBIR / 2014 / 1
Abstract: … have very significant impact on the operating conditions of the next generation nuclear accelerator facilities, that are used not only for scientific research but also for medical and commercial isotope manufacturing. As an example, the radio-pharmaceuticals… more

Development of Technologies that Address the Complex Architecture of the Face During the Treatment of Severe Facial Burn Injury

Company: Applied Tissue Technologies LLC Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: … (PWD) to be applied to severe facial burns, by a medic, at the time and site of injury. The PWD will envelop the head and form an enclosed treatment chamber that will enable immediate topical delivery of high-dose antibiotics, analgesics and anti-inflammatory drugs. Negative… more

Ultrafast Electron Diffraction Device for Time-Resolved Chemical Imaging

Company: Advanced Energy Systems, Inc. Agency/Program/Year/Phase: DOE / SBIR / 2014 / 2
Abstract: …. Commercial Applications and Other Benefits: The prototype X-band RF electron source we propose would find immediate application as a tabletop Ultrafast Electron Diffraction (UED) system for time-resolved chemical imaging, and as a resource for the pharmaceutical industry… more

X-ray Window Incorporating a Polymer Support Structure

Company: ML3 Scientific, Inc. Agency/Program/Year/Phase: DOE / SBIR / 2014 / 1
Abstract: …technology will allow the DOE to utilize new detector technology at its synchrotron light source sites which will enable faster X-ray analysis for many diverse fields such as crystallography, catalyst development, forensic sciences, the development of new pharmaceuticals,… more

Domestic, high-quality 2212 precursor powder for high temperature superconducting round wires

Company: Solid Material Solutions Agency/Program/Year/Phase: DOE / SBIR / 2014 / 1
Abstract: … for wire processing. This will serve as the basis for a pilot operation that will supply 2212 conductor development and production. Applications that benefit from this kind of 2212 conductor include 1) High field MRI machines used widely in medical and pharmaceutical research,… more

Enhancing the Pharmacokinetic Profile of Protein-based Drugs

Company: Extend Biosciences Inc. Agency/Program/Year/Phase: DOD / SBIR / 2014 / 2
Abstract: Many protein-based drugs have limited efficacy due to a short half-life or require intravenous delivery because of low bioavailability. Extend Biosciences is developing proprietary carrier molecules that allow proteins to access an intrinsic transport pathway for efficient… more

Direct Digital Secondary Electron Signal Acquisition Probe for Scanning Electron Microscope.

Company: Sciencetomorrow, Llc Agency/Program/Year/Phase: DOE / SBIR / 2014 / 2
Abstract: …. 2. Quantitative measurement will enhance process control, improve reliability prediction and design validation in semiconductors, photo-voltaic, bio-medical devices and catalysts. 3. Video and dynamic-imaging will advance nano-scale research in pharmaceutical and… more

A mechanism-based computational tool to optimize pulmonary drug delivery

Company: 3DT HOLDINGS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): Coronary artery disease (CAD) is a national and worldwide epidemic that places the largest clinical and economic burden on the healthcare system of any disease condition. Patients with stable and acute coronary conditions are often treated with percutaneous… more

Expanding Precision Particle Fabrication Technology for the Widespread Control of

Company: ORBIS BIOSCIENCES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2013 / 2
Abstract: DESCRIPTION (provided by applicant): A critical need currently exists in the pharmaceutical market for microparticles that can accurately and effectively control the release of poorly water-soluble compounds. Although these poorly water-soluble drugs areprojected to have high… more

A Human Fc Bifunctional Fusion Protein to Treat Severe Allergic Asthma

Company: TUNITAS THERAPEUTICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2013 / 2
Abstract: … plus down-regulation of afferent phase IgE antibody production. This phase 2 proposals comprises complimentary mechanism-of action experiments, efficacy studies and critical preclinical activities that are expected to provide a strong Investigational New Drug (IND… more

SBIR Phase I: Controlled Drug Release from and Degradation of PEG-Hydrogels

Company: ProLynx LLC Agency/Program/Year/Phase: NSF / SBIR / 2013 / 1
Abstract: … are independently predictable, simple to control, and do not show the initial bursts of drug release or terminal drug-dumping characteristic of encapsulating systems. Commercial success will be achieved by a) partnerships where we use our technology for proprietary drugs of … more

Body Worn EMG Controlling of Assistive Robotic Arm for Stroke Rehabilitation

Company: CARE TEAM SOLUTIONS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: …, reminders, monitors, and usage communicators have enabled an array of home health aids to support users and caregivers in pill management and monitoring. Beyond bulk pills, additional medication forms, such as topicals, are gaining popularity in unique drug delivery… more

System for PCS Agencies to Monitor, Investigate and Respond to Elder Safety Risks

Company: ADVANCED GENOMIC TECHNOLOGY, LLC Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: … (FTD), Lewy body (LBD), and Parkinson's disease (PD) with dementia (PDD). Success of this project will provide blood miRNA-based diagnostics for MCI, and predict conversion from MCI to AD, unprecedented tests to monitor disease onset, progression, and drug… more

Imaging Software of Functional Connectivity MRI for Alzheimer's Disease

Company: BRAINSYMPHONICS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2013 / 2
Abstract: … Connectivity MRI for Alzheimer's Disease , is written in response to (PA-11-134) Lab to Marketplace: Tools for Brain and Behavioral Research (SBIR [R43/R44]) . Alzheimer's disease (AD) is the most common form of dementia. However, developing drugs that… more

Urinary Biomarkers of Renal Mitochondrial Dysfunction

Company: SCHNELLGEN, INC. Agency/Program/Year/Phase: HHS / STTR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): The long-term goal of this project is to identify and validate biomarkers of mitochondrial dysfunction due to environmental stressors. Diverse acute insults from surgery, trauma, ischemia/reperfusion (I/R) and drug andenvironmental chemical… more

Genetically-delivered Bevacizumab for Treatment of Wet Age-Related Macular Degene

Company: REGENX BIOSCIENCES, LLC Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: …y system for bevacizumab (anti-VEGF antibody) to treat wet age-related macular degeneration (AMD). The premise is based on: (1)the demonstrated efficacy of monthly intravitreal injections of the monoclonal bevacizumab in treating wet AMD that is accompanied by a high cost of … more

IGF::OT::IGF Aerosolized Delivery of Anti-Tubercular Drugs

Company: PULMOKINE, INC. Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: Develop an inexpensive, easy to use, aerosolized delivery system of a combination of anti-tubercular drugs that could be used for the treatment of multi-drug resistant tuberculosis (MDR TB ). PUBLIC HEALTH RELEVANCE