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Development of Technologies that Address the Complex Architecture of the Face During the Treatment of Severe Facial Burn Injury

Company: KeraNetics, LLC Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: …ovative 3D printed halofuginone eluding keratin-based wound dressing that could potentially improve healing rates and reduce scarring and contracture in our burned Wounded Warriors. The proposed dressing will be formulated and tested for mechanical properties and drug delivery… more

High Specific Activity Sn-117m by Post Irradiation Isotope Separation

Company: IsoTherapeutics Group LLC Agency/Program/Year/Phase: DOE / SBIR / 2014 / 1
Abstract: … of interest in a variety of biomedical applications, including several in the fields of oncology and cardiology. While tin-117m can be produced through a variety of methods, there are limiting factors that must be addressed in order to facilitate drug… more

HERMES-Based X-Ray Strip Detector

Company: Sydor Instruments, LLC Agency/Program/Year/Phase: DOE / SBIR / 2014 / 2
Abstract: … as compared to present techniques. By acquiring data simultaneously at many points, the quality and quantity of data will be improved 100-fold from the current state of the art. These detectors will benefit a wide range of applications ranging from structure-based drug… more

Fast-Timing Large-Area Detector for Neutron Scattering

Company: Radiation Monitoring Devices, Inc. Agency/Program/Year/Phase: DOE / SBIR / 2014 / 1
Abstract: … to homeland security, nuclear and high-energy physics research, and the development of new sources to effectively address our nations future energy needs. The proposed detectors will also result in scientific research leading to the development of new drugs,… more

new SPM platform for heated probe AFM and Mass Spectrometry for naNoscale chemical analysis

Company: Anasys Instruments Corp Agency/Program/Year/Phase: DOE / SBIR / 2014 / 1
Abstract: … a MS. Mass spectrometry (MS) is one of the most widely used analytical techniques for chemical characterization. It is used routinely in a wide variety of industrial and academic laboratories in a wide set of applications such as polymers, pharmaceutics, life… more

Combined Extinction/Flourescence Absorption Diagnostics for Pharmaceutical Sprays

Company: En'Urga Inc. Agency/Program/Year/Phase: DOC / SBIR / 2014 / 1
Abstract: This Phase I project will evaluate the feasibility of a pharmaceutical spray quality audit system. The spray quality audit system will estimate the mass distribution of active ingredients and droplet sizes in pharmaceutical sprays using combined fluorescence absorption and light… more

Distributed SAR and GMTI using a Cooperative Sensor Network

Company: Intelligent Automation, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: … GMTI capability to detect victims in search and rescue operation in cluttered environments such as rough sea and forest. Similarly, law enhancement can use CORSON"s SAR capability to detect persons or facilities hidden under camouflage in border patrol or counter-drug… more

Rapid Low-Cost Biological Warefare Decontamination

Company: Lynntech, Inc. Agency/Program/Year/Phase: DHS / SBIR / 2014 / 1
Abstract: … and long term shelf life. Potential markets include first responders, military, medical and biomedical industry, and agriculture and industrial sectors for clean up and first response remediation. Alternative end user interest might include clandestine drug synthesis… more

Ricin Toxin Protective Monoclonal Antibodies with Improved Serum Half-Life

Company: Mapp Biopharmaceutical, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: … exposure. There are currently no methods of preventing or treating ricin exposure this represents a major unmet need for protection of civilians and warfighters. Because of their excellent safety profile and efficacy, mAbs are a rapidly growing class of therapeutic drugs… more

A novel process to produce air-stable core-shell nanoparticles for energetic applications

Company: NEI Corporation Agency/Program/Year/Phase: DOD / SBIR / 2014 / 2
Abstract: … ramjet engine inlets, ramjet fuels, self-ejecting combustible plumes for large-area heating, thermal battery heat sources and shaped-charge liners. Additional commercial applications include in situ soldering and welding, thermal battery heating pellets, airbags, drug… more

UV IR Image Combiner

Company: Physical Optics Corp. Agency/Program/Year/Phase: DOD / SBIR / 2014 / 2
Abstract: … structures and biological tissue, industrial inspection equipment for product verification and test, laser machining and drilling, microlithography, tissue welding and wideband imaging systems. Potential customers include aerospace, biomedical, pharmaceuticals,… more

Aerolized Vaccine Dose Analysis (AVIDA) System

Company: Physical Optics Corp. Agency/Program/Year/Phase: DOC / SBIR / 2014 / 1
Abstract: …e innovation in the system architecture enables high-speed acquisition of both fluorescence and scattering images at

A New Nb3Sn Process with a Novel Artificial Pinning Center for High Energy Physics and High Magnetic Field Applications

Company: Supramagnetics, Inc. Agency/Program/Year/Phase: DOE / SBIR / 2014 / 2
Abstract: … to 18T range. NMR spectroscopy is a non- destructive technique for mapping molecular structures and learning how molecules function and relate to each other. This is important for many applications that have benefits to the public including discovering new drugs, evaluating… more

Nano-Therapeutics for Peripheral Neuropathy

Company: Physical Optics Corporation Agency/Program/Year/Phase: DOD / SBIR / 2014 / 2
Abstract: … delivery system for topical treatment of peripheral neuropathy (PN), Physical Optics Corporation (POC) proposes to continue development of Nano Therapeutics for Peripheral Neuropathy (NATPEN) in Phase II. The NATPEN includes a nanocarrier (NC) loaded with specific drugs, a… more

HIGH PRESSURE MONOLITH ELECTROOSMOTIC PUMP

Company: MicroChem Solutions Agency/Program/Year/Phase: DOE / STTR / 2014 / 2
Abstract: … devices. Microchip HPLC can and will play an important role in point-of- care measurements, remote sensing and chemical and biological warfare agent detections. Highly parallel configurtaions can enhance the sample throughput considerably with commensurate impact on drug… more

Enhancing the Pharmacokinetic Profile of Protein-based Drugs

Company: Extend Biosciences Inc. Agency/Program/Year/Phase: DOD / SBIR / 2014 / 2
Abstract: Many protein-based drugs have limited efficacy due to a short half-life or require intravenous delivery because of low bioavailability. Extend Biosciences is developing proprietary carrier molecules that allow proteins to access an intrinsic transport pathway for efficient… more

Forensic Storage Bags for Radioactively Contaminated Samples

Company: Materials Modification Inc Agency/Program/Year/Phase: DOE / SBIR / 2014 / 1
Abstract: … disturb the chemistry of the TNF samples collected. Commercial Applications and Other Benefits: The technology as developed can be extended to many other applications, such as low-level radioactive waste storage, radioactive material transport, chemotherapy-drug… more

Low Z Thin Film Stripper Foils, Targets and X-Ray Windows

Company: UHV TechNologies, Inc. Agency/Program/Year/Phase: DOE / SBIR / 2014 / 1
Abstract: … have very significant impact on the operating conditions of the next generation nuclear accelerator facilities, that are used not only for scientific research but also for medical and commercial isotope manufacturing. As an example, the radio-pharmaceuticals… more

Development of Technologies that Address the Complex Architecture of the Face During the Treatment of Severe Facial Burn Injury

Company: Applied Tissue Technologies LLC Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: … (PWD) to be applied to severe facial burns, by a medic, at the time and site of injury. The PWD will envelop the head and form an enclosed treatment chamber that will enable immediate topical delivery of high-dose antibiotics, analgesics and anti-inflammatory drugs. Negative… more

Ultrafast Electron Diffraction Device for Time-Resolved Chemical Imaging

Company: Advanced Energy Systems, Inc. Agency/Program/Year/Phase: DOE / SBIR / 2014 / 2
Abstract: …. Commercial Applications and Other Benefits: The prototype X-band RF electron source we propose would find immediate application as a tabletop Ultrafast Electron Diffraction (UED) system for time-resolved chemical imaging, and as a resource for the pharmaceutical industry… more

Model-Based Compositional Reasoning for Complex Systems of Systems

Company: Dependable Computing LLC Agency/Program/Year/Phase: DOD / SBIR / 2014 / 2
Abstract: …, which requires a safety argument will be simplified through compositional assurance arguments. Numerous safety-critical industries will benefit from formal reasoning and compositional safety arguments, including: - the medical-device industry, for example drug… more

X-ray Window Incorporating a Polymer Support Structure

Company: ML3 Scientific, Inc. Agency/Program/Year/Phase: DOE / SBIR / 2014 / 1
Abstract: …technology will allow the DOE to utilize new detector technology at its synchrotron light source sites which will enable faster X-ray analysis for many diverse fields such as crystallography, catalyst development, forensic sciences, the development of new pharmaceuticals,… more

Domestic, high-quality 2212 precursor powder for high temperature superconducting round wires

Company: Solid Material Solutions Agency/Program/Year/Phase: DOE / SBIR / 2014 / 1
Abstract: … for wire processing. This will serve as the basis for a pilot operation that will supply 2212 conductor development and production. Applications that benefit from this kind of 2212 conductor include 1) High field MRI machines used widely in medical and pharmaceutical research,… more

Microfluidic automation platform for synthetic biology applications in the development and production of next-generation biofuels

Company: HJ Science & TechNology, Inc. Agency/Program/Year/Phase: DOE / STTR / 2014 / 1
Abstract: … overall efficiency of the FAEE production process. Commercial Applications and Other Benefits: In addition to biofuel, the proposed microfluidic automation technology has combinatorial DNA construction and functional screening in these industries: 1) pharmaceuticals,… more

Direct Digital Secondary Electron Signal Acquisition Probe for Scanning Electron Microscope.

Company: Sciencetomorrow, Llc Agency/Program/Year/Phase: DOE / SBIR / 2014 / 2
Abstract: …. 2. Quantitative measurement will enhance process control, improve reliability prediction and design validation in semiconductors, photo-voltaic, bio-medical devices and catalysts. 3. Video and dynamic-imaging will advance nano-scale research in pharmaceutical and… more