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Nanofluidic Sequencing of Polypeptides

Company: Agiltron Corporation Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: Leveraging Agiltron"s development and production of portable Raman spectrometers, Agiltron will develop a new class of polypeptide sequencers. Our approach capitalizes on recent progress in Raman spectroscopy to push the sensor performance well beyond the current… more

High-efficiency, Radiation-hardened GaN HEMT based L-band Space Power Amplifier

Company: CFD Research Corporation Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: ABSTRACT: An important objective for the Air Force is to reduce the operational costs of GPS satellite systems via higher efficiency electronics, such as power amplifiers. In this project, CFDRC, in collaboration with Vanderbilt University/ISDE and a leading GaN device manufacturer, propose a… more

Small Footprint LIDAR for Continuous Monitoring of Atmospheric State Variables

Company: Physical Sciences Inc. Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: … propagation of not only radar but other RF systems. Improving the capability for monitoring the atmosphere will increase the effectiveness of Navy systems. Physical Sciences Inc., in collaboration with its subsidiary Q-Peak Inc., proposes to develop an advanced, compact Raman… more

Novel Extended-Zone High Power WDM Couplers

Company: Q Peak, Inc. Agency/Program/Year/Phase: DOD / STTR / 2014 / 1
Abstract: …iber components. A range of fiber sizes and device specifications will be developed and commercially offered by Q-Peak. The component that we propose to develop in this Phase I program fulfills an important need as an enabling technology specifically for high-power fiber Raman… more

A Miniaturized SERS Based Sensor Technology for detecting toxic contaminants in oxygen from aircraft On-Board Oxygen Generating Systems (OBOGS)

Company: Sporian Microsystems, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2014 / 2
Abstract: … a visual alarm indicator, and an electronic output signal that can interface with an aircraft's caution and warning system. The objective of the proposed work is to develop such a sensing module, based on the combination of a miniaturized surface enhanced Raman… more

High Power WDM Based Upon Mode Coupling

Company: AdValue Photonics Inc Agency/Program/Year/Phase: DOD / STTR / 2014 / 1
Abstract: … fibers. BENEFIT: High power fiber laser systems are usually limited by the unavailability of highly-reliable fiber-optic devices with high power handling capacity (>100W). High power WDM is an enabling device for some core-pumped applications, such as high-power … more

Low Loss, High Average Power PM WDMs for Raman Fiber Lasers

Company: PolarOnyx, Inc Agency/Program/Year/Phase: DOD / STTR / 2014 / 1
Abstract: … amplifier/laser can be applied to ophthalmology, refractive surgery, photocoagulation, general surgery, therapeutic, imaging, and cosmetic applications. Biomedical instruments include those involved in cells or proteins, cytometry, and DNA sequencing; laser Raman… more

Development of a Fiber Optically Coupled Raman Video Probe for the Non-Destructive Inspection of Concrete in Light Water Reactors

Company: Eic Laboratories, Inc. Agency/Program/Year/Phase: DOE / SBIR / 2014 / 2
Abstract: … time. Technologies that can assess the integrity of LWR structures and provide means to mitigate the degradation of reactor structures will help prolong reactor life and diminish the risks of structural failure. A portable, nondestructive assessment (NDA) Raman spectroscopy… more

High Spatial Resolution Ultrafast Sum-Frequency Generation Microscope

Company: Physics Materials and Applied Mathematics Research LLC Agency/Program/Year/Phase: DOE / STTR / 2014 / 1
Abstract: Vibrationally resonant sum-frequency generation (SFG) spectroscopy is a second order nonlinear optical technique that features high chemical selectivity and a set of selection rules that makes it an ideal complement to coherent Raman scattering (CRS) as an imaging tool. Attempts… more

Protease chain reactions for molecular analysis of cancer markers

Company: Agiltron Corporation Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: … of ultrasound. Furthermore, all of these techniques are inadequate to identify the last residual cells that remain in the resection bed. Agiltron, in collaboration with Wayne State University, proposes to develop a robust, sensitive, selective, and low cost Raman image… more

Radiation-Hardened Memristor-based Memory for Extreme Environments

Company: CFD Research Corporation Agency/Program/Year/Phase: NASA / SBIR / 2013 / 1
Abstract: NASA space exploration missions require radiation-hardened memory technologies that can survive and operate over a wide temperature range. Memristors (memory-resistors) are a promising technology for the next generation of non-volatile memory (NVM) applications and offer a highly-desirable… more

Nondestructive Evaluation of Thick Outer Mold Line Paints and Coatings

Company: ChromoLogic LLC Agency/Program/Year/Phase: DOD / SBIR / 2013 / 1
Abstract: … and measurements of capacitance and dissipation have been used extensively for NDE of coatings, but incapable of depth profiling, identification, and tracking of chemically based degradation that occurs in-use. Ultrasound, Forward-Looking Infrared Systems (FLIR), and Raman… more

RIDES: Raman Icing Detection System

Company: Michigan Aerospace Corporation Agency/Program/Year/Phase: NASA / SBIR / 2013 / 1
Abstract: Michigan Aerospace Corporation proposes to develop an integrated LIDAR instrument capable of identifying icing conditions while also providing air data sensing capabilities. The resulting Raman Icing Detection System (RIDES) will be an integrated air data sensing and icing… more

Volcanic Ash Detection Using Raman LIDAR: "VADER"

Company: Michigan Aerospace Corporation Agency/Program/Year/Phase: NASA / SBIR / 2013 / 1
Abstract: … significant hazard to aircraft engine and electronics and has caused damage to unwary aircraft and disrupted air travel for thousands of travelers, costing millions of dollars. Michigan Aerospace Corporation (MAC) proposes to demonstrate the concept feasibility of a Raman… more

Multi-kW Fiber Lasers Based on Novel Light Guide Combiners

Company: nLight Photonics Agency/Program/Year/Phase: DOD / SBIR / 2013 / 1
Abstract: ABSTRACT: The efficient coherent beam combination of a master oscillator power amplifier (MOPA) system requires a reduction in non-linearities of the power amplifier sections. Fiber non-linearities, such as stimulated Brillouin scattering (SBS) and stimulated Raman scattering… more

Real-time label-free detection of suspicious powders using non-contact optical methods

Company: Photon Systems Agency/Program/Year/Phase: DOD / SBIR / 2013 / 1
Abstract: … comprised of these basic subunits. These current methods include immunoassays or PCR, both of which require expensive equipment and reagents with limited shelf life and restrictive environmental conditions for storage and use. Current optical methods such as Raman… more

Ultra-Compact Optical Spectrometer for Organic Mapping, uCOSOM (microcosm)

Company: Photon Systems Agency/Program/Year/Phase: NASA / SBIR / 2013 / 2
Abstract: … provides a broad organic and inorganic compound measurement capability without the need for sample handling or reagents.It will excite sub-ppb levels of organic compounds on rocks, soil, or other surfaces in the deep UV below 250 nm and simultaneously measure Raman… more

SBIR Phase I: Hand-held Reagentless Trace Chemical (TraC) Water Quality Sensor

Company: Photon Systems Agency/Program/Year/Phase: NSF / SBIR / 2013 / 1
Abstract: …t are designed to remove nitrogen through Simultaneous Nitrification and DeNitrification (SNdN). This is an example of a major source of potential environmental contamination. The technology of the proposed innovative sensor is deep ultraviolet excited resonance Raman (DUV-RR)… more

Compact Raman Lidar for Aerosol Extinction Profiling from Small UAVs

Company: Physical Sciences Inc. Agency/Program/Year/Phase: DOE / SBIR / 2013 / 1
Abstract: Recent work by several groups has resulted in the recognition of the potential for Arctic tundral regions to become a significant net source of carbon greenhouse gases from thawing permafrost. As the Arctic region responds to climate forcings, monitoring how aerosol distributions respond and modify… more

High-resolution optical imaging and spectroscopy instrument for real-time characterization of soft tissue constructs

Company: Physical Sciences Inc. Agency/Program/Year/Phase: DOD / SBIR / 2013 / 2
Abstract: …, microstructure, and overall tissue state and maturity for transplantation. In a Phase I study, Physical Sciences Inc. (PSI) in collaboration with the Center for Regenerative Medicine at the Massachusetts General Hospital (MGH), investigated the use of combined Raman… more

Networkable Automated Water Vapor Lidar for Tropospheric Profiling

Company: Physical Sciences Inc. Agency/Program/Year/Phase: DOE / STTR / 2013 / 2
Abstract: …chanical design and subjecting it to thermoelastic analysis. The Phase II program will fabricate an engineering prototype and demonstrate it at the DoE Southern Great Plains site for several months. It will be intercompared with balloon-borne radiosondes and with the sites … more

Simplifying encoding of bioassays to accelerate translational drug discovery

Company: Physical Sciences Inc. Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): Physical Sciences, Inc. (PSI), in collaboration with The Forsyth Institute, Cambridge, MA proposes to investigate the use of combined Raman microspectroscopy-Optical Coherence Tomography (OCT) imaging for in vivo diagnosis of tooth decay,… more

Generation, Detection, and Control of Ultrafast Nonlinear Optical Processes in High Energy Density Plasmas Using Spike Trains of Uneven Duration and Delay

Company: Polymath Research, Inc. Agency/Program/Year/Phase: DOE / SBIR / 2013 / 1
Abstract: …. We will accomplish this by (i) adopting the appropriate method of generating a pump laser composed of spike trains of uneven duration and delay (STUD pulses), (ii) adopting the appropriate method of detecting and diagnosing the amplified transmission of a stimulated Raman… more

Development of truly noninvasive ultrafast imaging diagnostics and advanced plasma flow solver for fundamental studies of low-temperature, non-equilibrium plasmas

Company: Spectral Energies, LLC Agency/Program/Year/Phase: DOE / SBIR / 2013 / 1
Abstract: …d two photon laser induced fluorescence (fs-TPLIF) technique; (ii) The development of 1-D imaging of electric field distribution, and rotational/translational temperature and vibrational distribution function, using fs coherent Anti-Stokes Raman scattering… more

A Miniaturized SERS Based Sensor Technology for detecting toxic contaminants in oxygen from aircraft On-Board Oxygen Generating Systems (OBOGS)

Company: Sporian Microsystems, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2013 / 1
Abstract: … visual alarm indicator, and an electronic output signal that can interface with an aircraft's caution and warning system. The objective of the proposed work is to develop such a sensing module, based on the combination of a miniaturized surface enhanced Raman scattering… more