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Aircraft Wheel-Tire Dynamic Interface Pressure

Company: Innovative Scientific Solutions, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: …ficant push into contact force measurement using technologies such as our patented S3F. This proposal is one example. ISSI is specifically teaming with Bertec Corp. and the University of Akron to develop a system for measurements of shear stress on the feet of diabetics for… more

Retinal Image Management System (RIMS)

Company: Kitware Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: ABSTRACT: Retinal damage is a debilitating condition, which, if left untreated, can lead to blindness. This condition is widespread and has many causes, ranging from accidental exposure to environmental dangers, to complications of disease such as diabetes (… more

Novel Manufacturing Processes for Tissue Engineered Vascular Grafts

Company: HUMACYTE, INC. Agency/Program/Year/Phase: HHS / SBIR / 2013 / 2
Abstract: … of Technologies for Heart, Lung, Blood and Sleep Disorders and Diseases (R44) . This RFA solicits work on basic, applied, and clinical research on all product and service development related to the mission of the NHLBI... including cardiovascular complications of diabetes… more

Urinary Biomarkers of Renal Mitochondrial Dysfunction

Company: SCHNELLGEN, INC. Agency/Program/Year/Phase: HHS / STTR / 2013 / 1
Abstract: …, liver and kidney). Furthermore, mitochondrial dysfunction can contribute to cell injury through increasedproduction of reactive oxygen and nitrogen species. Mitochondrial dysfunction is also a component of many chronic diseases such as metabolic syndrome, diabetes,… more

Neurorestorative Strategy for Diabetic Peripheral Neuropathy

Company: 3-C INSTITUTE FOR SOCIAL DEVELOPMENT Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): Early childhood research indicates that school readiness is a key determinant of a successful transition to school. Between 9.5% and 14.2% of young children experience social-emotional problems that negatively impact school-readiness, and nearly half of children… more

Development of a TAVI Device with a Reduced Crossing Profile

Company: ABEOME CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): Obesity is considered the number one health problem in the US and Europe, affecting 10% to 30% of adult populations. Obese individuals are more likely to acquire a variety of secondary diseases including diabetes, heartproblems, immune… more

Development of an Electromyographically Controlled Electrolarynx Voice Prosthesis

Company: XERIS PHARMACEUTICALS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): The program outlined in this application has been designed to accelerate the development and commercialization of a Glucagon Mini-Dose Pen to change the paradigm for treatment of moderate hypoglycemia in insulin-using diabetics. This research… more

Clinical Development of a Stable Glucagon Formulation for Bi-hormonal Pump

Company: XERIS PHARMACEUTICALS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2013 / 2
Abstract: DESCRIPTION (provided by applicant): The objective of this program is to further the development of a novel, stable, non-aqueous glucagon formulation as an integral component of a bi-hormonal (insulin-glucagon) pump system for treatment of persons with diabetes. The addition of… more

Non-Invasive Treatment for Uveitis

Company: ACIONT, INC. Agency/Program/Year/Phase: HHS / SBIR / 2013 / 2
Abstract: … of a sustained release drug delivery device into the eye. Thus, there is a great need to develop a superior drug delivery system in terms of safety, patient acceptance and efficacy for uveitis. The same product could be used to treat other indications such as diabetic… more

Development of a wearable telemetry module and dual hormone infusion set for use

Company: ADVANCED MEDICAL ELECTRONICS CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: …s Corporation (AME) and the University of Minnesota propose to develop a new graphene based continuous glucose monitor with passive wireless readout capability and dissolvable / biocompatiblemetallization layers for use in close-loop glucose control applications. Diabetes is the… more

System for Increasing Patient Access to Eye Exams for Diabetic Retinopathy

Company: AEON IMAGING, LLC Agency/Program/Year/Phase: HHS / SBIR / 2013 / 2
Abstract: Project Summary / Abstract - EY020017 Phase IIB Competitive Renewal The overall goal of the proposed SBIR program is to implement and evaluate a low cost, portable retinal camera, the DLP-Cam, in a primary care system for diabetic retinopathy (DR) screening. Untreated DR has… more

Continuous Monitoring of Glycemic Oscillations in Interstitial Fluid

Company: ULTRADIAN DIAGNOSTICS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2013 / 2
Abstract: … measurements within interstitial fluid were highly correlated with reference glucose measurements. Moreover, measurements of glucose oscillations within subcutaneous tissue showed clear differences between normal subjects and those with type 1 and type 2 diabetes. Further… more

STTR Phase II: Microgames for Improving Pediatric Compliance

Company: ArchieMD, Inc Agency/Program/Year/Phase: NSF / STTR / 2013 / 2
Abstract: … Phase II project will harness the popularity and ubiquity of mobile microgames on hand-held devices for educating children on self-management of chronic health conditions. Millions of children suffer from chronic conditions which require regular management, such as diabetes,… more

Kiddio: Food Fight - Training Vegetable Parenting Practices

Company: ARCHIMAGE, INC. Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): Higher vegetable intake has been related to lower risks of diabetes, cardiovascular disease, several cancers, and obesity/adiposity later in life. Yet, children are eating vegetables well below recommended amounts. Parents are important… more

Pediatrician Office Drug Prevention

Company: ATHERSYS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: … care. In fact, taken together, CVD is the leading cause of death in the United States and is responsible for an estimated 287 billion dollars annually in direct and indirect costs, according the American Heart As the population ages and the incidence of diabetes and obesity… more

Rapid detection of methylglyoxal in blood samples

Company: BIOO Scientific Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): Diabetes is a serious, life-threatening disease caused by improper absorption and metabolism of glucose. Increased glucose levels can lead to an accumulation of toxic sugar degradation products, such as methylglyoxal (MG), in the bloodstream.… more

Neurorestorative therapy of stroke with HUCBC in T2DM rats

Company: SANERON CCEL THERAPEUTICS, INC. Agency/Program/Year/Phase: HHS / STTR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): Diabetes mellitus (DM) leads to a 3-4 fold higher risk of experiencing ischemic stroke. In addition, DM stroke patients are more prone to develop more and earlier white matter (WM) high-intensity lesions than non DM stroke patients. Treatment… more

hiPS Derived Cardiomyocyte Assay for Screening Toxicant Differentiation Effects

Company: CELL AND TISSUE SYSTEMS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: … the obesogenesis assay sensitivity. PUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: According to the US Centers for Disease Control more than one-third of U.S. adults (35.7%) are obese. Obesity-related conditions include heart disease, stroke, type 2 diabetes and… more

Developing A Novel Therapy for Diabetic Retinopathy

Company: CHARLESSON, LLP Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): Diabetic retinopathy (DR) is a common complication of diabetes and a leading cause of vision loss in the United States. Unfortunately, there is no FDA-approved pharmacotherapy for DR. Current treatments in clinical… more

CDX-301 and Plerixafor Combination in Stem Cell Mobilization for Transplantation

Company: COGNOSCI, INC. Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): Diabetic peripheral neuropathy (DPN) is one of the most common and devastating complications of diabetes mellitus, affecting more than 50% of diabetic patients, and is the leading cause of foot amputation. DPN, characterized by peripheral… more

Micro Patterned Intraocular Lens Membrane for Reducing Incidence of PCO

Company: SHARKLET TECHNOLOGIES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): The exponential increase of diabetics and the elderly in the U.S. has at least tripled cataract surgeries in just two decades. As many as half of these surgeries will lead to posterior capsular opacification (PCO), which requires follow-up… more

Long-Term Non-Enzymatic Glucose Sensors for an Artificial Pancreas

Company: Giner, Inc. Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: … and function at high cell densities thus minimizing overall implant size. The oxygen generator will be powered by a remotely rechargeable battery. The first proposed application of this platform technology is pancreatic islet implant for the treatment of Type 1 diabetes (T1D).… more

Advanced In-Shoe Orthotic Treatment for Foot Pain

Company: DIAPEDIA, LLC Agency/Program/Year/Phase: HHS / SBIR / 2013 / 2
Abstract: … for accelerating to market a new device that will provide an evidence-based, patient-specific solution to a significant public health problem: foot pain. The TrueContour(R) therapeutic insole system was originally conceived for prevention of forefoot injury in diabetes… more

Diabetes Prevention: Interactive DPP Curriculum for Virtual Small Group Delivery

Company: DISCOVERY GENOMICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): Pancreatic cancer represents the 10th most common cancer diagnosis, yet the 4th most common estimated cause of death. The only potential curative therapy for pancreatic cancer is surgical resection; however, few patients have tumors which can be respected.… more

A Low-Cost, Portable Guidance System for Needle Biopsy

Company: ENVIRONMENT AND HEALTH GROUP, INC. Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): Over three-quarters of Hispanic women in the US are overweight or obese. High rates of excess body weight place these women at heightened risk for a variety of illnesses and health conditions, such as Type 2 diabetes, coronary heart disease,… more