Search

Peripheral administration of nonpeptide somatostatin agonists for ophthalmic dise

Company: CRINETICS PHARMACEUTICALS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: … boomers , age-related eye diseases are common and becoming more prevalent. Currently, it is estimated that 11 million Americans suffer from age-related macular degeneration (AMD) - a number that is expected to double in the next generation. The first world diabetes epidemic… more

Development and Evaluation of a Universally Designed App to Support Self Directed Diabetes Education and Self Management for Individuals with Intellectual Disabilities

Company: AbleLink Technologies, Inc. Agency/Program/Year/Phase: ED / SBIR / 2014 / 1
Abstract: While research shows there is an increasing incidence of diabetes in Americans, there is also a compelling body of research showing that individuals with intellectual disabilities (ID) are even more likely to suffer the effects of diabetes, which include increased risk of heart… more

Glucagon Mini-Dosing Pen for Treatment of Hypoglycemia

Company: XERIS PHARMACEUTICALS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 2
Abstract: DESCRIPTION (provided by applicant): The program outlined in this application has been designed to accelerate the development and commercialization of a Glucagon Mini-Dose Pen to change the paradigm for treatment of moderate hypoglycemia in insulin-using diabetics. This research… more

A Healthy Dining Worksite Program Contributing to Healthier Eating in Restaurants

Company: ACCENTS ON HEALTH, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): The economic and social costs related to obesity and other diet-related conditions (e.g., several forms of cancer, heart disease, type two diabetes, and more) are extensive. The worksite setting represents a channel through which hundreds of… more

Cost-Effective OCT Detection of Vision-Threatening Macular Edema

Company: AEON IMAGING, LLC Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: … The combined DLO-OCT system will cost-effectively identify patients with vision-threatening macular edema for referral and treatment. Vision loss due to untreated macular edema has reached epidemic levels and is the resultof a wide variety of conditions, including diabetes and… more

Development of selective Cav3 channel blockers for treatment of neuropathic pain

Company: AFASCI, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: …. T-type Ca2+ channels play key roles in pain signaling. The Cav3 family of channels is involved in at least two key stages of pain pathways: first, at the dorsal root ganglion (DRG) and again at the thalamic pain relay. Both chronic nerve constriction injury and diabetic… more

Novel cell-based Restorative Approach in Treatment of Diabetes-related Retinopath

Company: TARGAZYME, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Retinal vascular diseases remain a common cause of vision loss and blindness with diabetes as the most common condition leading to retinopathy in adults in Western society. In particular, with type 1 diabetes the majority of patients will… more

SBIR Phase I: A Novel Extended Delivery Dual-action Platform for Peptide-based Anti-fibrotics

Company: ANGION BIOMEDICA CORPORATION Agency/Program/Year/Phase: NSF / SBIR / 2014 / 1
Abstract: … extended-release scaffold might necessitate administration only once monthly or even less frequently. By encapsulating a variety of highly potent drugs from insulin to growth factors, custom platforms can be designed to treat a host of indications such as diabetes, keloid… more

Kiddio: Food Fight - Training Vegetable Parenting Practices

Company: ARCHIMAGE, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 2
Abstract: DESCRIPTION (provided by applicant): Higher vegetable intake has been related to lower risks of diabetes, cardiovascular disease, several cancers, and obesity/adiposity later in life. Yet, children are eating vegetables well below recommended amounts. Parents are important… more

Riboswitch Based Methyltransferase HTS Assay for Epigenetic Drug Discovery

Company: BELLBROOK LABS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Epigenetic regulation of gene expression via methylation has been implicated in diverse diseases including cancer, diabetes and inflammation, and high throughput screening for histone methyltransferase (HMT) inhibitorsis an area of intense… more

Choroidal Blood Flow Imaging with Spectral Domain OCT

Company: BIOPTIGEN, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Ophthalmic vascular diseases impact millions of Americans. Age-related macular degeneration and diabetic retinopathy are the two major diseases with a well- known vascular factor. The role of the vascular system in glaucoma and retinopathy of… more

Intrasurgical Optical Coherence Tomography

Company: BIOPTIGEN, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Each year, over 20 million ophthalmic surgeries are performed worldwide. Indications for ophthalmic surgery include potentially blinding diseases, such as cataracts, diabetic retinopathy, macular disease, and retinal detachment. Surgeons… more

Bilingual Foto-tabloids in Community Newspapers

Company: ACMA SOCIAL MARKETING Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Diabetes among Hispanics has reached epidemic proportions. (1) [Pre-diabetes] education is key in diabetes prevention and control yet education tools that translate into culturally engaging, yet simple and easy to understand information is a… more

Mobile Health App to Reduce Diabetes in Latina Women with Prior Gestational Diabe

Company: ENVIRONMENT AND HEALTH GROUP, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Hispanic women have the highest lifetime risk for type 2 diabetes (T2DM). A window of opportunity for preventing T2DM exists for women with pregnancies complicated by gestational diabetes mellitus (GDM). Women with prior GDM face increased… more

Evaluation Of A Novel Connexin-Based Peptide For The Treatment Of Diabetic Wounds

Company: FIRSTSTRING RESEARCH, LLC Agency/Program/Year/Phase: HHS / SBIR / 2014 / 2
Abstract: Project Summary/Abstract According to the ADA, 25.8 million children and adults have diabetes. Diabetics have an increased risk of complications such as heart disease and are prone to impaired wound healing. A major cause of morbidity and hospitalizationis diabetic foot… more

Portable Gas Perfusion System for Pancreas Preservation

Company: GINER, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 2
Abstract: DESCRIPTION (provided by applicant): Pancreatic islet transplantation (ITx) is an emerging treatment for a subset of Type 1 diabetics for which standard insulin therapies are insufficient. I is a promising alternative to pancreas transplantation, since ITxhas significantly less… more

Replaceable Long Term Implanted Glucose Sensor

Company: GLYSENS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: ? DESCRIPTION (provided by applicant): Diabetes is a major health care problem that has reached crisis proportions. The disease accounts for gt14% of total national health care expenditures in the US and untold losses of precious human resources, and new therapies are… more

Clinical Evaluation of a Long Term Implanted Glucose Sensor

Company: GLYSENS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 2
Abstract: DESCRIPTION (provided by applicant): Diabetes is a major healthcare problem that is reaching crisis proportions, and new therapies are urgently needed. We have developed a long term, fully self-contained glucose monitoring sensor with battery-operated telemetry for implantation… more

Infrared Eyes

Company: EDEN MEDICAL, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: …ndexing methodology. The iREyes will offer a user-friendly product with a significantly lower cost (lt 500) than today's existing infrared microbolometer technology. The iREyes will also identify hot spots associated with repetitive stress to reduce ulceration risk. … more

Aircraft Wheel-Tire Dynamic Interface Pressure

Company: Innovative Scientific Solutions, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: …ficant push into contact force measurement using technologies such as our patented S3F. This proposal is one example. ISSI is specifically teaming with Bertec Corp. and the University of Akron to develop a system for measurements of shear stress on the feet of diabetics for… more

Quad-Rider Accessible Handcycle

Company: INVOTEK, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Physical activity may improve the health and quality of life of people with spinal cord injury and disease (SCI/D) by slowing or reversing physiological decline, lowering risk factors for cardiovascular disease and diabetes, improving… more

Retinal Image Management System (RIMS)

Company: Kitware Inc. Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: ABSTRACT: Retinal damage is a debilitating condition, which, if left untreated, can lead to blindness. This condition is widespread and has many causes, ranging from accidental exposure to environmental dangers, to complications of disease such as diabetes (… more

Measurement of Beta Cell Death in Diabetes

Company: L2 DIAGNOSTICS, LLC Agency/Program/Year/Phase: HHS / STTR / 2014 / 2
Abstract: DESCRIPTION (provided by applicant): All forms of diabetes are characterized by the death of insulin producing ? cells. In Type 1 diabetes (T1D) this leads to the reliance on exogenous insulin for survival. Death of ? cells is silent - it cannot be detected in vivo until it has… more

Novel Hydrocyanine Probes for the Accurate Detection of Reactive Oxygen Species

Company: LI-COR BIOSCIENCES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: DESCRIPTION (provided by applicant): Reactive oxygen species (ROS) are involved in numerous cell-signaling pathways. They have been implicated in over 150 diseases including cancer, arthritis, Parkinson's disease, diabetes, myocardial infarction and atherosclerosis. The… more

Next Generation Western for high-throughput and high-content protein analysis

Company: LI-COR BIOSCIENCES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2014 / 1
Abstract: …, quantification, and repeatability, which hinder many research efforts. An example is the challenge in determining expression levels of multiple proteins in the very small samples associated with pancreatic islets and mouse biopsies used in research related to diabetes and… more