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Advanced Heavy Fuel Injection System for UAS/UGS Applications

Company: Mainstream Engineering Corporation Agency/Program/Year/Phase: DOD / SBIR / 2014 / 1
Abstract: … of providing multiple injections per engine cycle at engine speeds up to 6000 RPM. To overcome the barriers associated with spark ignition of direct-injected heavy fuel (JP5, JP8, etc.), Mainstream will leverage previous internal research on diesel spray and … more

TEM Holder System for Accurate Monitoring and Control of Environmental Conditions During in-situ Liquid Cell TEM Using Integrated pH and Temperature Sensors

Company: Hummingbird Precision Machine Co, Dba Hummingbird Agency/Program/Year/Phase: DOE / SBIR / 2014 / 2
Abstract: … to obtain transmission electron micrographs of materials at atomic resolution while in liquid environments. However, no product currently on the market allows the TEM data to be correlated with other environmental parameters directly measured in … more

Encapsulation Technology for Increased Environmental Stability of Vertebrate Cells

Company: Luna Innovations Incorporated Agency/Program/Year/Phase: DOD / SBIR / 2014 / 2
Abstract: …ne lung microvessel endothelial cell line when stored at room temperature in ambient air. Phase II will focus on extending the cell viability and function for an increased variety of cell types while also working to integrate the stabilization technology into a microfluidic chip… more

Microfluidic-based device for ambient mass analysis

Company: MassTech Inc Agency/Program/Year/Phase: DOE / SBIR / 2014 / 1
Abstract: …mass spectrometry (MS/MS). Broad applicability of nanoDESI-based MS analysis makes it a unique analytical tool specifically targeting trace amounts of many chemical and biological substances. During implementation of this project we plan to develop and test a microfluidic… more

Portable Microfluidic Platform for Real-Time, High Sensitive Detection and Identification of Trichloroethylene and Other Organochloride Compounds

Company: Hj Science & Technology, Inc. Agency/Program/Year/Phase: DOE / SBIR / 2014 / 2
Abstract: … measurement technology at laboratory level, the real-time on-site monitoring technologies for chlorinated organic compounds are still lacking both in terms of selectivity and sensitivity. HJ Science & amp; Technology proposes to build a novel portable microfluidic… more

SBIR Phase II Topic 272: Low-Cost Microfluidic System for Detection of CTCs; Peri

Company: BIOFLUIDICA MICROTECHNOLOGIES, LLC Agency/Program/Year/Phase: HHS / SBIR / 2013 / 2
Abstract: Not Available

Droplet-Based Automation of Complex Workflows for Synthetic Biology

Company: ADVANCED LIQUID LOGIC Agency/Program/Year/Phase: DOD / STTR / 2013 / 1
Abstract: … a single target, or single methodology. Currently, an automation platform does not exist that enables a broad range of genome engineering methods directed towards a diverse range of biomanufactured products. Advanced Liquid Logic (ALL) has developed digital microfluidics, a… more

Automated Sample Preparation for Next Generation Sequencing Cancer Diagnostics

Company: ADVANCED LIQUID LOGIC Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: … sequencing on NGS platforms. Tumor and nontumor genotypes can then be discerned through bioinformatic analysis of the resulting sequencing data. To better enable deep sequencing of tumor biopsies, Advanced Liquid Logic (ALL) will apply its proprietary digital microfluidic… more

Distributed REMD Simulation for Probing Alzheimer Molecular Mechanisms

Company: ADVANCED LIQUID LOGIC Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: DESCRIPTION: Mass spectrometry is a multiplex technology for high-throughput analysis of biomolecules in newborn screening and clinical laboratories. Complexity in sample preparation has been recognized as the main bottleneck in well-established MS methods. Digital … more

Point-of-Care Nucleic Acid Test for Cytomegalovirus for Newborn Hearing Screening

Company: ADVANCED LIQUID LOGIC Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: …re sensitive than the dried blood spots traditionally used by the newborn screening laboratories. Newborn screening programs do not have the infrastructure necessary to use newborn saliva samples and molecular assays. Advanced Liquid Logic's digital microfluidic technology… more

Point-of-Care Nucleic Acid Test for Cytomegalovirus for Newborn Hearing Screening

Company: ADVANCED LIQUID LOGIC Agency/Program/Year/Phase: HHS / SBIR / 2013 / 2
Abstract: …re sensitive than the dried blood spots traditionally used by the newborn screening laboratories. Newborn screening programs do not have the infrastructure necessary to use newborn saliva samples and molecular assays. Advanced Liquid Logic's digital microfluidic technology… more

A rapid and high-throughput microfluidic stem cell analyzer

Company: CFD Research Corporation Agency/Program/Year/Phase: DOD / SBIR / 2013 / 2
Abstract: Current methods to discern the differentiation state of stem cells are time-consuming, labor-intensive, costly, invasive, and consequently, ill-suited for clinical applications. To overcome these limitations, we propose to develop a microfluidic stem cell analyzer for accurate,… more

Paper-Based, Multi-Fueled Enzymatic Fuel Cell with Passive Microfluidic Flow

Company: CFD Research Corporation Agency/Program/Year/Phase: DOD / SBIR / 2013 / 2
Abstract: … with proven expertise in electrochemical power sources, biomicrosystems, bioelectrochemistry, and system design has been assembled to accomplish these goals. BENEFIT: The major outcome of this project will be a bioelectrochemical system with a paper-based microfluidic… more

A Novel Thioredoxin Mimetic Prodrug for Prevention of Bronchopulmonary Dysplasia

Company: CORSOLUTIONS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: DESCRIPTION (provided by applicant): The merging of cell culture and microfluidic technology has resulted in improved in vitro models for toxicity studies, drug development, and biomedical research. The reason for which microfluidic approaches provide a more accurate in vitro… more

Identification and Validation of Targets of Phenotypic High Throughput Screening

Company: PROSOLIA, INC. Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: … device that enables direct analysis of a variety of materials including biological tissue and live microorganisms that promises to deliver on this objective. The basis for this device is the Liquid Micro junction Surface Sampling Probe (LMJSSP), a set of coaxial … more

Encapsulation Technology for Increased Environmental Stability of Vertebrate Cells

Company: Luna Innovations Incorporated Agency/Program/Year/Phase: DOD / SBIR / 2013 / 1
Abstract: … while still retaining physiological cellular activity. Phase II will focus on extending the cell viability and function to a minimum of 6 months for an increased variety of cell types while also working to integrate the stabilization technology into a microfluidic chip for… more

SBIR Phase I: Quantitative space-time control for high contrast multiphoton microscopy

Company: Mesa Photonics, LLC Agency/Program/Year/Phase: NSF / SBIR / 2013 / 1
Abstract: … space and time, which not only impacts imaging, but all commercial applications of femtosecond lasers. For example, plasma-mediated ablation utilizes amplified femtosecond pulses and is a powerful process that is incorporated in a broad range of industries includes … more

Interactive Web Program and Health Coaching for Prehypertensive Adults

Company: NESHER TECHNOLOGIES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: … diagnostic utility for ultrasensitive protein as well as miRNA quantification at clinically relevantconcentrations without amplification. Furthermore, recent work by our consultants Profs. Steve Quake and Shimon Weiss shows i) combination of microfluidics- based sample… more

COMPUTERIZED CROSS-CULTURAL COMPETENCY ASSESSMENT PROGRAM FOR HEALTH ORGANIZATION

Company: NESHER TECHNOLOGIES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2013 / 1
Abstract: … 4-color (4c) ALEX, substantially expanding its multiplexing power, and demonstrated diagnostic utility for detection of proteins and nucleicacids. Furthermore, recent work by our consultants Profs. Steve Quake and Shimon Weiss shows i) combination of microfluidics-based sample… more

Micro-fluidic spectrometer for measuring groundwater contamination

Company: Southwest Sciences, Inc. Agency/Program/Year/Phase: DOE / SBIR / 2013 / 2
Abstract: Past industrial practices have resulted in groundwater that is contaminated by heavy metals. Long-term monitoring and maintenance is one of the largest costs of environmental management. This project is developing a compact analyzer for measuring chromium ions in ground water that should… more

Remotely Controlled Mixers for LMM Colloid Samples

Company: TECHSHOT, INC. Agency/Program/Year/Phase: NASA / SBIR / 2013 / 2
Abstract: … in the LMM that could lead to new advanced materials with significant commercial potential. Capitalizing on Techshot's rapid progress with the LMM-DS, the company's vast array of mixing and separations technologies, and its extensive experience with microfluidic… more

Development of a Long Term pH and pCO2 Lagrangian Drifter

Company: Sunburst Sensors, LLC Agency/Program/Year/Phase: DOC / SBIR / 2013 / 2
Abstract: … can be widely deployed in the world’s oceans. Sunburst Sensors proposes to develop an innovative, reasonably priced pH and pCO2 measurement system for oceanic surface drifters. Indicatorbased opto-fluidic sensors have been designed and fabricated using microfluidic… more

SBIR Phase II: Nutrient Analyzer with Integrated Optics and Glass-Diaphragm Pump for Field Studies

Company: Translume Agency/Program/Year/Phase: NSF / SBIR / 2013 / 2
Abstract: This Small Business Innovation Research Program (SBIR) Phase I project will entail the development of a microfluidic colorimetric analyzer to yield quantitative field measurements out of essential inorganic nutrients (initially nitrite and nitrate, thereafter ammonium and… more

Terahertz Frequency Spectrometer Combined with Sub-Wavelength Microfluidic Platform

Company: VIBRATESS Agency/Program/Year/Phase: DOD / STTR / 2013 / 1
Abstract: …spectrometer prototype with sub-wavelength spatial resolution for use in the spectroscopic and temporal analysis of trace material samples in advanced sensing and monitoring applications. The instrument operating at room temperature will include a periodic-grating microfluidic… more

Microfluidic Pneumatic Autoinjector Platform

Company: Physical Optics Corporation Agency/Program/Year/Phase: DOD / SBIR / 2013 / 1
Abstract: …tor technology that provides the warfighter with a compact, field-ready, cost-effective platform for long-term storage of any given CBT antidote that does not present a significant logistical burden, Physical Optics Corporation (POC) proposes to develop a Microfluidic Pneumatic… more