SBIR Phase I: Designing an Immune System Response Into High-Temperature Ceramic Matrix Composite Materials (CMC)
Company: Free Form Fibers LLC Agency/Program/Year/Phase: NSF / SBIR / 2013 / 1Abstract: …fort aims to enhance these functions and add to them a material "immune response" capable of local detection of oxygen intrusion, followed by automatic compositional changes which resist further oxygen ingress, and finally the creation of "scar tissue" that… more
SBIR Phase I: Novel Polymer Brush-like Architecture for Temperature Dependent Cell Release and Attachment
Company: Innovative Surface Technologies, Inc. Agency/Program/Year/Phase: NSF / SBIR / 2013 / 1Abstract: … by providing novel polymer brush-like architectures to the culture surface to reduce protein adsorption, and allow efficient hydration to release the strongly adherent cells. Moreover, addition of functionalities to polymer brush-like architectures will increase the adhesive… more
SBIR Phase I: New Fluorescent Biosensors for Signaling in Living Cells
Company: MONTANA MOLECULAR, LLC Agency/Program/Year/Phase: NSF / SBIR / 2013 / 1Abstract: … of this project is that multiplex, genetically-encoded assays reporting multiple cell signaling events would expand the depth of knowledge about signal transduction by improving information on the timing, location and pathway cross-talk in physiologically relevant tissues.… more
SBIR Phase I: Grip-Act-Reposition Miniaturized Stable Working Platform for Minimally Invasive Procedures Inside Active Organs
Company: Piezo Resonance Innovations, Inc. Agency/Program/Year/Phase: NSF / SBIR / 2013 / 1Abstract: …. The catheter needs significant flexibility to negotiate the path to the target organ - which inherently limits control of the working end. In catheter ablation for treating atrial fibrillation (AF), for example, a radiofrequency ablation catheter creates scar tissue lines… more
SBIR Phase I: High Throughput Silver Nanowire Manufacturing
Company: Seashell Technology Agency/Program/Year/Phase: NSF / SBIR / 2013 / 1Abstract: … electronic devices. This is particularly evident for silver nanowires, which have been recognized as the most promising replacement for indium tin oxide in transparent conductor manufacture. Silver nanowires are also superior to silver flake filler used in conductive adhesives… more
SBIR Phase I: Peptide-modified Hyaluronic Acid Biopolymers for Soft Tissue Augmentation, Protection and Rejuvenation
Company: Wasatch Molecular Inc. Agency/Program/Year/Phase: NSF / SBIR / 2013 / 1Abstract: …ess Innovation Research (SBIR) Phase I will focus on development of novel biopolymers obtained by covalently attaching peptide side chains to hyaluronic acid (HA) backbone polymer chains through carefully controlled chemistry. The resulting material can be used for soft tissue… more
SBIR Phase I: Superpenetration Multiphoton Microscopy with MEMS SLMs
Company: Boston Micromachines Corporation Agency/Program/Year/Phase: NSF / SBIR / 2013 / 1Abstract: This Small Business Innovation Research Program (SBIR) Phase I project aims to develop and demonstrate a superpenetration multiphoton microscope (S-MPM) that will more than double the imaging depth achievable in highly scattering biological tissue. MPM technology has… more
SBIR Phase I: A Bioactive Hernia Mesh Containing Choroid Plexus Factors For Improved Tissue Integration
Company: CYTOSOLV INC. Agency/Program/Year/Phase: NSF / SBIR / 2013 / 1Abstract: This Small Business Innovation Research (SBIR) Phase I Project continues the development of the choroid plexus (CP) growth factor cocktail for application to biologic hernia meshes to treat the challenging hernia repair market. CP factors represent a broad spectrum of potent biologic molecules that… more
SBIR Phase I: Tissue Engineered Sustainable Leather
Company: MODERN MEADOW Agency/Program/Year/Phase: NSF / SBIR / 2013 / 1Abstract: This Small Business Innovation Research (SBIR) Phase I project will investigate the application of a novel tissue engineering approach to the fabrication of animal products, in particular leather. The approach relies on the automated deposition of conveniently prepared… more
SBIR Phase I: An Optically-Efficient Miniaturized Raman Optical System for Trending Glucose Levels
Company: eLutions Integrated Systems, Inc. Agency/Program/Year/Phase: NSF / SBIR / 2013 / 1Abstract: … light scattered by chemical species to distinguish, identify, and quantify them based on the shifted spectrum found in their optical fingerprint. The fingerprint of glucose can be used to key in and register its changes in concentration over time in biological tissues, such… more
SBIR Phase II: Sprayable Reversible Hemostat for Treatment of Non-Compressible Hemorrhage
Company: Remedium Technologies, Inc. Agency/Program/Year/Phase: NSF / SBIR / 2013 / 2Abstract: …, which is the leading cause of death (~90%) for bleeding-related trauma. The foam material is based on the biopolymer chitosan; a modification to this polymer with novel hydrophobic grafts allows the material to clot blood much more rapidly and adhere to tissue more… more
SBIR Phase I: An Environmentally Sustainable Approach to PVC-Free Flooring
Company: Interfacial Solutions LLC Agency/Program/Year/Phase: NSF / SBIR / 2013 / 1Abstract: … replacement to PVC in the flooring market. A novel process to continuously create sheet materials has also been determined. To complete the development of this technology and disrupt incumbent products, the new technology needs to be advanced to improve the adhesive bonding… more
SBIR Phase I: Physical Cellular High Content Screening Using a piggyBac Transposen System
Company: ArunA Biomedical, Inc. Agency/Program/Year/Phase: NSF / SBIR / 2013 / 1Abstract: … interrogate complex cell cultures is important since it is believed that many diseases, drug side effects, and environmental phenotypes are the result of multi-cellular interactions that have been disrupted, leading to physical changes at the complex cell/tissue level.… more
SBIR Phase I: Nanofibrillar Scaffolds for Tissue Engineering
Company: Fibralign Corporation Agency/Program/Year/Phase: NSF / SBIR / 2013 / 1Abstract: This Small Business Innovation Research Phase I project will investigate manufacturability of the proposed innovation in the field of tissue engineering, overcome related research challenges, and estimate the market opportunity. We have developed, tested and patented novel… more
SBIR Phase I: Quantitative Phase Imaging for Life Sciences
Company: Phi Optics, Inc. Agency/Program/Year/Phase: NSF / SBIR / 2013 / 1Abstract: This Small Business Innovation Research Program Phase I project proposes a new instrument for imaging live cells and tissues. The instrument addresses the current shortcomings of state-of-the art techniques: expensive and invasive contrast agents that bias the results and… more
SBIR Phase I: Use of Automated Multiparametric Strain Analysis Technology (MPS) as a Diagnostic Test for Heart Disease
Company: CardioWise Agency/Program/Year/Phase: NSF / SBIR / 2013 / 1Abstract: …hase I project proposes to develop in-clinic proof of concept for fully automated cardiac multiparametric strain analysis (MPS) technology capable of identifying left ventricular (LV) contractile injury. The innovation in this technology is centered not in MRI tissue tagging… more
SBIR Phase I: Highly sensitive magnetic devices for biomedical applications
Company: Picosense Agency/Program/Year/Phase: NSF / SBIR / 2013 / 1Abstract: …netocardiography (MCG) of the human heart. Portable cardiography has been limited to electrocardiography (ECG) sensors for decades. ECG is not suitable for continuous heart-rate monitoring (e.g. for in-home use by elderly patients) since it requires conductive (adhesive)… more
SBIR Phase I: Non-Thermal Plasma Device for Wound Disinfection and Promotion of Wound Healing
Company: Sterionics, Inc. Agency/Program/Year/Phase: NSF / SBIR / 2013 / 1Abstract: … bacterial viability. Phase I work will define the ionic, molecular, and radiation species present in the plasma plume for a wider range of feed gas, and determine which species are most effective at achieving bacterial disinfection, how deep into the infected tissue the… more
SBIR Phase I: Preparation and Characterization of Polymer based Biodegradable Nanoparticles of Novel Inhibitors of Cell Proliferation
Company: Advanced Technologies for Novel Therapeutics Agency/Program/Year/Phase: NSF / SBIR / 2013 / 1Abstract: … cell proliferation. The development of polymer-based biodegradable nanoparticles is guided by the desire to improve overall survival and quality of life by increasing the bioavailability of drug to the site of disease, containing delivery to the cancerous tissues, increasing… more
SBIR Phase I: Bioprinted Prevascularized Adipose Graft for Soft Tissue Voids
Company: TeVido BioDevices LLC Agency/Program/Year/Phase: NSF / SBIR / 2013 / 1Abstract: This Small Business Innovation Research Phase I project proposes a new tissue engineered vascularized adipose graft product for reconstructive surgery. Of the approximately one million new breast cancer cases worldwide, many patients choose mastectomy due to a lack of viable… more
SBIR Phase I: New Photoacoustic Imaging System for Cancer Screening Based on Illumination-through-CMUT-Transducer Design
Company: Advanced MicroSensors Corporation Agency/Program/Year/Phase: NSF / SBIR / 2013 / 1Abstract: … the image target through the CMUT array. The unique features of this illumination-through-transducer design are in that 1) there is no need for external alignment mechanisms between the transducer and the light source during image acquisition, 2) depth at which the tissue can… more
SBIR Phase I: Ice-release Coatings
Company: Polymer Exploration Group, LLC Agency/Program/Year/Phase: NSF / SBIR / 2013 / 1Abstract: … fluids, energy inefficient electrical heating, and deicing coatings with high cost but poor mechanical toughness. The proposed coating is based on (1) a recent fundamental study that revealed a heretofore unrecognized combination of critical parameters controlling ice adhesion,… more
SBIR Phase I: Magnetic Sifter for Rapid Isolation of Rare Cells
Company: CytoMag, LLC Agency/Program/Year/Phase: NSF / SBIR / 2013 / 1Abstract: … using fetal cells in maternal blood, and stem cell isolation for regenerative medicine. A device based on the same separation principles could be used to isolate stem cells for implantation in infarcted myocardium, non-union bone fractures, and many other tissues. This… more
OTHER FUNCTIONS CIRCULATING TUMOR CELL ENUMERATION PRODUCT
Company: EPIC SCIENCES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2Abstract: …II controct application is submitted in response to the invitation that was extended after successful completion of the phase I entitled 'Circulating Tumor Cell Enumeration Product'. The Phase /I will demonstrate dinical utility of the product as a surrogate for tissue… more
Oral, replicating Ad4-HIV vaccine development and evaluation in NHP challenge model
Company: PAXVAX, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2Abstract: …h was formulated for administration in an oral dosage form. Oral delivery should be advantageous for HIV vaccines because this route of administration is morelikely to induce mucosal immune responses than parenteral injection and would target the gut mucosal tissues in… more