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Agency:HHS
Year:2011
Phase:Phase I
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Displaying 26 – 50 of 782 Awards
Company: CELEK PHARMACEUTICALS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: CEL-031 is being developed as a novel, targeted tre8tment for non-mLiscle invasive bladder cancer (NMIBC). Bladder cancer is the 5th most common cancer in the US, with most cases diagnosed 8t the nonmuscle invasive stage. It is the most expensive cancerto treDt on a per patient basis. There is 8… more
Company: SEACHANGE PHARMACEUTICALS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): Goals: The goal is to develop a computational system to predict the targets toward which small molecules are biased. The tool will optimize biased libraries, prioritize them for testing against particular targets, identify targets in phenotypic screens, and allow… more
Company: Farus, LLC Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): External fetal heart monitors (FHM) allow for intermittent or continuous monitoring of fetal status both before and during labor, and reduce medical costs by allowing fewer nurses or midwives to manage larger number patients. However, current external FHMs are… more
Company: LIFE BIOSCIENCE, INC. Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): Membrane proteins are an essential component of intercellular signaling pathways. The overwhelming majority of small molecule drugs, either directly or indirectly, target membrane proteins. Arrays of membrane proteins would be important tools in drug screening… more
Company: HEMOSHEAR, LLC Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): Drug developers desperately need better tools in the laboratory to improve the 90% failure rate of drugs in clinical trials. Liver toxicity is still the leading cause of drug failure, despite extensive preclinical testing in surrogate animal species. HemoShear… more
Company: CARMOT THERAPEUTICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): A novel approach to discover selective small molecule inhibitors of FABP4 and FABP5 for the treatment of metabolic diseases The Western diet and lifestyle has brought an epidemic of health problems collectively referredto as metabolic syndrome. Obesity plays a… more
Company: ADURO BIOTECH Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): Despite the availability of a safe and effective prophylactic vaccine for hepatitis B virus (HBV), each year a significant number of new infections are reported to the CDC in the United States. Worldwide more than 2 billion people have been infected with HBV,… more
Company: RXI PHARMACEUTICALS CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): Introduction of small interfering RNAs (siRNAs) into cells with transfection reagents results in potent and specific gene silencing by RNA interference (RNAi). Unfortunately, while siRNA-based drugs represent a potentially significant therapeutic paradigm, the… more
Company: RXI PHARMACEUTICALS CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): Project Summary / Abstract Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting motor neurons in the central nervous system. Degeneration of the motor neurons results in paralysis and eventual death, usually due to… more
Company: NEURODX DEVELOPMENT, LLC Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): This Phase 1 SBIR will develop a non-invasive alternative to radionuclide shunt patency testing for evaluating Normal Pressure Hydrocephalus (NPH) patients with suspected shunt malfunction. Hydrocephalus is a disorder of cerebrospinal fluid dynamics that is… more
Company: NEURODX DEVELOPMENT, LLC Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): This Phase 1 SBIR will develop Continuous Real Time (CRT) ShuntCheck, the first portable, non- invasive device for real time, continuous monitoring of flow in CSF shunts. This device will result in improved clinicalmanagement of hydrocephalus by providing a… more
Company: BRAIN PLASTICITY, INC. Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): The primary objective of this Phase I proposal is to develop and evaluate a novel, brain-based and web-deliverable multimedia training program targeting the treatment of social cognition deficits in schizophrenia. Social cognition impairments have been directly… more
Company: BRAIN PLASTICITY, INC. Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): The primary objective of this Phase I application is to develop and deploy a novel, neuroplasticity- based, computerized training program that has been shown to drive positive changes in attention, working memory and executive function in a vulnerable aging… more
Company: CONVERGENCE MEDICAL DEVICES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): Our goal is to provide neurologists and other clinicians a method for the rapid, painless, non-invasive evaluation of children with neuromuscular disease. Pediatric neuromuscular disorders include muscular dystrophies, spinal muscular atrophy, and… more
Company: DOUBLE S INSTRUCTIONAL SYSTEMS Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): People with intellectual disabilities (ID) have rates of obesity greater than the general population. They often have poor energy dense diets and tend to be inactive. This group also experiences a high prevalence of health related problems: cancer, diabetes,… more
Company: CYNVENIO BIOSYSTEMS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: The evolving understanding of cancer indicates every tumor has distinct characteristics driven by the molecular pathology of the disease. Predicted by this heterogeneity, targeted therapeutic agents are much more successful than a one size fits all approach. Currently, there are no tools to… more
Company: CYNVENIO BIOSYSTEMS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: Improvement of treatment outcomes for patients with solid tissue tumors depends on the drug s ability to target the genetic mutations responsible for tumor growth. Currently, mutational analysis requires an invasive tissue biopsy, which is clinically impractical to perform repeatedly. Alternatively,… more
Company: Synaptic Research, Llc Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): Induced pluripotent stem cells (iPSC) have tremendous potential for regenerative medicine in future. However, there are obstacles to overcome before the iPSC can be used therapeutically. One major hurdle is the tool used to generate iPSC from adult somatic cells.… more
Company: Ventrix Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): Heart failure following a myocardial infarction (MI) continues to remain a leading killer in the western world. In the United States, the estimated annual incidence of myocardial infarction (MI) is 745,000 new and 410,000 recurrent episodes. Approximately 22% of… more
Company: WISDOM TOOLS Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): This SBIR project, Case Study Investigation: Contextual Reconstruction of Accidents for Safety and Health (CSI: CRASH): Using Immersive Learning and Cross Platform Mobile Solutions to Address Accident Investigations from a Multi-Perspective Standpoint, seeks to… more
Company: SIMQUEST , LLC Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): SimQuest LLC proposes to develop a physics-based head and neck simulator to enhance training of dental, endodontic, oral, maxillofacial, plastic, trauma, ENT, and other trainees and surgical educators. This Phase I workwill advance the state of the science in… more
Company: HEARTHSTONE ALZHEIMER CARE, LTD Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): An estimated 5.3 million Americans are currently suffering from Alzheimer's disease (AD), and AD cases are expected to rise at an alarming rate (AD; Alzheimer's Association, 2010). Therefore, market potential exists forproducts, approaches, and/or… more
Company: MC3, INC. Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): Mitral valve regurgitation is a serious condition related to heart disease. The most common and effective surgical method for treating this disease is with the use of an annuloplasty ring, which reduces the size of a dilated mitral valve to restore normal… more
Company: FHC, INC. Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): Malignancies of the brain are among the most devastating diseases known. Glioblastoma multiform (GBM) in particular are known for their rapid, uncontrolled, and aggressive growth. Very little progress has been made in the treatment of GBM over the past 25 years.… more
Company: NANOSCALE MATERIALS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: The goal of the project is to develop a rapid in vitro screening assay for detection of cancer biomarkers in urine and blood. The aim is testing and optimization of nanoparticle sensors, based on cyanine dyes that are chemically linked to Fe/Fe3O4 nanoparticles via protease-selective consensus… more
Displaying 26 – 50 of 782 Awards
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