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Agency:HHS
Phase:Phase I
Program:SBIR
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Displaying 20901 – 20925 of 22474 Awards
Company: Biogen Research Corp Agency/Program/Year/Phase: HHS / SBIR / 1987 / 1
Abstract: POLYMORPHIC CELL-SURFACE MOLECULES ENCODED BY THE MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) OF VERTEBRATES ARE RESPONSIBLE FOR INITIATING A NUMBER OF PHYSIOLOGICAL RESPONSES WHEN THESE ANTIGENS ARE RECOGNIZED AS "NONSELF" BY THE IMMUNE SYSTEM. THE REJECTION OF DONOR TISSUE GRAFTS BY RECIPIENTS WHOSE… more
Company: Biogen Research Corp Agency/Program/Year/Phase: HHS / SBIR / 1987 / 1
Abstract: A MODEL SYSTEM FOR PRODUCTION OF RECOMBINANT PROTEINS IN MILK USING MICE WILL BE DEVELOPED IN PHASE I. THIS WILL ESTABLISH THAT IT IS POSSIBLE TO PRODUCE NOVEL PROTEINS IN MILK FROM MAMMARY TISSUES. A PROMOTER SPECIFIC FOR MAMMARY CELLS WILL BE USED TO DIRECT THE EXPRESSION OF A TEST PROTEIN THAT IS… more
Company: BIOGRAPHICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 1987 / 1
Abstract: N/A
Company: BIOLOG, INC. Agency/Program/Year/Phase: HHS / SBIR / 1987 / 1
Abstract: GRAM-POSITIVE BACTERIA ARE RESPONSIBLE FOR A MAJOR PORTION OF BACTERIAL INFECTIONS. ALTHOUGH SOME SPECIES IN THIS GROUP ARE EASILY IDENTIFIED, BETTER GENERAL IDENTIFICATION METHODS ARE NEEDED. IT IS EXPECTED THAT BIOLOG, INC.'S NEW TECHNOLOGY WILL PERMIT IDENTIFICATION OF THE COMMONLY ADDRESSED… more
Company: Biomagnetic Technologies Agency/Program/Year/Phase: HHS / SBIR / 1987 / 1
Abstract: N/A
Company: Biomaterials International Inc Agency/Program/Year/Phase: HHS / SBIR / 1987 / 1
Abstract: A NEED EXISTS TO QUANTITATE ANESTHETIC AND RESPIRATORY GASES(O2, CO2, N2) IN THE OPERATING ROOM. PREVIOUS WORK HAS SHOWN THAT RAMAN LIGHT SCATTERING CAN BE SUCCESSFULLY UTILIZED FOR MOLECULAR GAS ANALYSIS. THE RAMAN SIGNAL FOR EACH GAS CAN BE SEPARATED FROM THE LASER BEAM RAYLEIGH SCATTER VIA FILTER… more
Company: Biomaterials International Inc Agency/Program/Year/Phase: HHS / SBIR / 1987 / 1
Abstract: THE DEVELOPMENT OF A FIBEROPTIC PH PROBE IS PROPOSED USING A FLUORESCENT DYE IMMOBILIZED IN A HYDROPHILIC GEL MATRIX. THE MAIN TASKS IN THIS PROJECT ARE: (1) SET-UP OF RESEARCH INSTRUMENTATION FOR MEASURING AND CHARACTERIZING EXPERIMENTAL PROBES, (2) SELECTION AND IMMOBILIZATION OF DYES AT THE TIP… more
Company: Biomaterials International Inc Agency/Program/Year/Phase: HHS / SBIR / 1987 / 1
Abstract: THE ANTICOAGULANT, HEPARIN, WILL BE DERIVATIZED WITH BIOLOGICALLY COMPATIBLE HYDROPHOBIC MACROMOLECULES TO MAKE THEM WATER INSOLUBLE. THIS DERIVATIZATION WILL OCCUR THROUGH HYDROPHILIC SPACER GROUPS, ALLOWING THE HEPARIN TO EXTEND INTO THE AQUEOUS ENVIRONMENT AND RETAIN ITS BIOACTIVE CONFIGURATION.… more
Company: Biomaterials International Inc Agency/Program/Year/Phase: HHS / SBIR / 1987 / 1
Abstract: USING THE MOUSE PERITONEAL IMPLANT MODEL, MATERIALS WILL BE EVALUATED FOR THEIR BIOCOMPATIBILITY. THE OBJECTIVE OF THISSTUDY WILL BE TO DEVELOP MATERIALS WITH MINIMAL TENDENCY FORCELLULAR AND TISSUE ADHESION. POLYURETHANES AND SILICONES, MATERIALS WIDELY USED IN BIOMEDICAL DEVICE FABRICATION, WILLBE… more
Company: SURMODICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 1987 / 1
Abstract: SERIOUS ATTENTION HAS BEEN FOCUSED ON THE USE OF ILLICIT DRUGS BY AMERICANS IN ALL WALKS OF LIFE. ONE OF THE MOST ABUSED DRUGS FOR OVER TWO DECADES HAS BEEN MARIJUANA, WHICH IS NOW BEING USED BY BLUE- AND WHITE-COLLAR WORKERS, MILITARY PERSONNEL, PROFESSIONAL ATHLETES, AND HIGH SCHOOL STUDENTS.… more
Company: SURMODICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 1987 / 1
Abstract: BIO-METRIC SYSTEMS, INC. PROPOSES TO DEVELOP A SEMIQUANTITATIVE, NONLABORATORY ENZYME IMMUNOASSAY THAT IS EXPECTED TO BE SENSITIVE, RAPID, AND CONVENIENT TO USE. THIS IMMUNOASSAY WILL REQUIRE NO INSTRUMENTATION AND IS EXPECTED TO HAVE A SINGLE-STEP PROTOCOL: SIMPLY DIP THE APPARATUS IN THE SAMPLE,… more
Company: SURMODICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 1987 / 1
Abstract: N/A
Company: SURMODICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 1987 / 1
Abstract: N/A
Company: Biopolymers Inc Agency/Program/Year/Phase: HHS / SBIR / 1987 / 1
Abstract: FOR OVER 30 YEARS, A MAJOR GOAL OF VASCULAR SURGERY HAS BEEN TO IMPROVE BYPASS SURGERY THROUGH THE DEVELOPMENT OF AN IDEAL PROSTHETIC GRAFT. ALTHOUGH SAPHENOUS VEIN IS THE PREFERRED SUBSTRATE FOR OCCLUDED SMALL-TO-MEDIUM VEINS, FREQUENTLY IT IS UNAVAILABLE OR UNSUITABLE FOR A GREAT NUMBER OF… more
Company: Bioquant, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1987 / 1
Abstract: THE LONG-TERM OBJECTIVE OF THIS PROJECT IS TO PROVIDE FOR THE ENDOCRINE COMMUNITY A COLLECTION OF SPECIFIC MONOCLONAL ANTIBODIES (MOABS) WITH ESPECIALLY HIGH AFFINITY FOR A NUMBER OF HORMONES AND RECEPTORS BEING ACTIVELY UTILIZED IN RESEARCH. THE SPECIFIC AIM OF THIS PHASE I PROJECT IS TO DEVELOP… more
Company: Bioquant, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1987 / 1
Abstract: N/A
Company: Bioquant, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1987 / 1
Abstract: N/A
Company: Bioresources Laboratories Inc Agency/Program/Year/Phase: HHS / SBIR / 1987 / 1
Abstract: THE TECHNOLOGY OF PRODUCING HYBRIDOMAS AND OTHER CLONED CELL LINES THAT SECRETE IMMUNOREACTIVE SUBSTANCES, SUCH AS MONOCLONAL ANTIBODIES, IS NOW COMMANDING ATTENTION IN ALL FIELDS OF BIOLOGY. THE WIDE APPLICABILITY OF MONOCLONAL ANTIBODIES AS HIGHLY SPECIFIC REAGENTS AND THE INCREASING NUMBER OF… more
Company: Biosearch Technologies, Inc Agency/Program/Year/Phase: HHS / SBIR / 1987 / 1
Abstract: A NEW APPROACH WILL BE DEVELOPED FOR PERFORMING AMINO ACID ANALYSIS OF PROTEIN HYDROLYSATES. IT WILL EMPLOY A UNIQUE DERIVATIZING REAGENT THAT IS CAPABLE OF REACTING WITH ALL AMINO ACIDS IN PROTEIN HYDROLYSATES. THESE INCLUDE PROLINE,CYSTEINE, AND TRYPTOPHAN, AMINO ACIDS THAT ARE TYPICALLY DIFFICULT… more
Company: Biosearch Technologies, Inc Agency/Program/Year/Phase: HHS / SBIR / 1987 / 1
Abstract: PRELIMINARY RESEARCH PERFORMED AT BIOSEARCH, INC. HAS CONFIRMED THAT MODIFIED INORGANIC MATERIALS MAY HAVE SUPERIOR PHYSICAL AND CHEMICAL PROPERTIES FOR ATTACHMENT AND ASSEMBLY OF PEPTIDE CHAINS DURING SOLID-PHASE PEPTIDE SYNTHESIS. THESE SUPPORTS ARE BELIEVED TO PROVIDE A MORE MORE FAVORABLE… more
Company: Biosearch Technologies, Inc Agency/Program/Year/Phase: HHS / SBIR / 1987 / 1
Abstract: AT PRESENT, PROGRESS IN PEPTIDE SYNTHESIS IS LIMITED BY THE RIGOROUS PURIFICATION AND CHARACTERIZATION PROCESSES THAT ARE NECESSARY IN BOTH OF THE TWO CURRENTLY ACCEPTED PEPTIDE SYNTHESIS METHODS. BIOTECHNOLOGY, AS WELL AS BIOCHEMICAL AND PHARMACEUTICAL RESEARCH, WILL BENEFIT FROM THE INTRODUCTION… more
Company: SERACARE LIFE SCIENCES, INC. Agency/Program/Year/Phase: HHS / SBIR / 1987 / 1
Abstract: NIH RESEARCHERS HAVE RECENTLY ANNOUNCED THE ISOLATION OF A HUMAN B-LYMPHOTROPIC VIRUS (HBLV) FROM SIX INDIVIDUALS WITH VARIOUS LYMPHOPROLIFERATIVE AND IMMUNE DISORDERS. HBLV APPEARS TO BELONG TO THE GROUP OF HUMAN HERPES VIRUSES AND MAY BE ASSOCIATED WITH B LYMPHOPROLIFERATIVE DISORDERS. EARLY… more
Company: SERACARE LIFE SCIENCES, INC. Agency/Program/Year/Phase: HHS / SBIR / 1987 / 1
Abstract: A NOVEL HUMAN B-LYMPHOTROPIC VIRUS (HBLV) HAS BEEN RECENTLY ISOLATED FROM PATIENTS WITH LYMPHOPROLIFERATIVE DISORDERS. THIS HERPES VIRUS HAS BEEN SHOWN TO INFECT B AND T LYMPHOCYTES AND TO ALTER THEIR MORPHOLOGY AND GROWTH CHARACTERISTICS. THE SIGNIFICANCE OF THE VIRUS IN CAUSING HUMAN DISEASES HAS… more
Company: Biostar Medical Products, Inc Agency/Program/Year/Phase: HHS / SBIR / 1987 / 1
Abstract: THE NEW INTERFERENCE COLOR SLIDE PROPOSED FOR IMMUNOASSAYS PRODUCES THE DESIRED COLOR CHANGES IN A WET STATE. THIS TECHNIQUE WILL BRING ASSAYS CLOSER TO A ONE-STEP PROCESS THAN EXISTING TECHNOLOGY. WITHOUT THE RINSING AND DRYING STEPS, THE WET TECHNIQUE WILL BE SIMPLER AND FASTER THAN ELISA. THE… more
Company: Biostar Medical Products, Inc Agency/Program/Year/Phase: HHS / SBIR / 1987 / 1
Abstract: A NEW INSTRUMENT IS PROPOSED FOR THE STUDY OF MONOMOLECULAR ORGANIC FILMS. THIS INSTRUMENT CONSISTS OF AN IMAGING ELLIPSOMETER VIEWFINDER AND A ONE-SPOT THICKNESS-MEASURING PHOTOMETER VISIBILE IN THE VIEWFINDER. WITH THE VIEWFINDER,MONOMOLECULAR PROTEIN SPOTS COULD BE SEEN ON THE SURFACE OF A SLIDE,… more
Displaying 20901 – 20925 of 22474 Awards
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