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Agency:HHS
Phase:Phase I
Program:SBIR
Company: A Woman's Health Concern Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: TUMOR NECROSIS FACTOR (TNF) IS A 17,000-DALTON POLYPEPTIDE SECRETED BY MACROPHAGES WHICH HAS ANTITUMOR CYTOLYTIC ACTIVITY. TNF DOES NOT APPEAR TO AFFECT NORMAL CELLS AND HAS BEEN SHOWN REPEATEDLY TO EITHER KILL OR PREVENT THE GROWTH OF TUMOR CELLS IN BOTH IN VITRO AND IN VIVO MODEL SYSTEMS. TNF IS… more
Company: A Woman's Health Concern Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: INCREASING THE THERAPEUTIC EFFICACY OF MANY ANTICANCER DRUGS.THE LONG-RANGE GOAL OF THIS PROPOSAL IS TO DEVELOP AN IN VITRO TEST TO IMPROVE SELECTIONS OF THERAPIES FOR INDIVIDUAL BREAST CANCER PATIENTS BY PREDICTING RESPONSE TO METHOTREXATE. EXISTING ASSAYS FOR BREAST CANCER CELLS CANNOT DETERMINE… more
Company: Agouron Pharmaceuticals Inc. Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: IMMUNOLOGICAL AND DNA HYBRIDIZATION ASSAYS WHICH EMPLOY SPECIFIC ANTIBODY AND DNA PROBES ARE PROVING TO BE VERY VALUABLE IN THE IDENTIFICATION OF PATHOGENS AND IN THE DIAGNOSIS OF GENETIC DISEASES. THE OBJECTIVE OF THIS PROJECT IS TO IMPROVE THE SENSITIVITY, SAFETY, AND CONVENIENCE OF DIAGNOSTIC… more
Company: Air Care, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: THE PURPOSE OF THE RESEARCH IS TO DEVELOP A TOTAL TRANSPORTATION SYSTEM DESIGNED TO MEET THE COMMUTING NEEDS OF THE ELDERLY AND HANDICAPPED. IT WILL COMBINE PRE-EXISTING GROUND PARATRANSPORTATION WITH AN AIR COMMUTER THAT IS MEDICALLY SUPPORTED. THE PROPOSED SYSTEM WILL PROVIDE GROUND TRANSPORTATION… more
Company: Albany Cardiothoracic Surgeons Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: THIS IS AN APPLICATION FOR A PHASE I CONTRACT IN WHICH WE WILL EVALUATE THE FEASIBILITY OF USING A NEW CANCER TREATMENT REGIMEN IN HUMANS. THE OVERALL GOAL OF THIS PHASE I STUDY WILL BE TO DETERMINE THE TOXICITY AND ANTITUMOR ACTIVITY OF THIS NEW REGIMEN IN RABBITS. THE INFORMATION DERIVED FROM THE… more
Company: RADIATION MONITORING DEVICES, INC. Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: PERIDONTAL DISEASE IS ONE OF THE MOST WIDESPREAD MEDICAL PROBLEMS FACING THE NATION TODAY. CRUCIAL TO THE SUCCESSFUL TREATMENT OF THIS DISEASE IS EARLY DETECTION AS WELL AS CAREFUL MONITORING OF THE PROGRESS OF THE PERIODONTAL THERAPY. THERE ARE, HOWEVER, FEW EFFECTIVE APPROACHES TO THIS PROBLEM AND… more
Company: RADIATION MONITORING DEVICES, INC. Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: N/A
Company: RADIATION MONITORING DEVICES, INC. Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: N/A
Company: RADIATION MONITORING DEVICES, INC. Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: N/A
Company: RADIATION MONITORING DEVICES, INC. Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: N/A
Company: American Biointerface Corp Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: GOOD RECOVERY OF MOTOR FUNCTION FOLLOWING SEVERE DAMAGE TO THE HUMAN NERVOUS SYSTEM, PRIMARILY THE CENTRAL NERVOUS SYSTEM, IS DIFFICULT TO ACHIEVE. THERE MAY BE A NUMBER OF REASONS WHY THE REGENERATIVE RESPONSE TO INJURY WOULD NOT LEAD TO FUNCTIONAL RECOVERY, AND A VARIETY OF METHODOLOGIES HAVE… more
Company: American Biorganics, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: TISSUE CULTURE MEDIA ARE CURRENTLY SUPPLIED IN STERILE LIQUID AND NONSTERILE POWDERED FORMS. THERE IS A NEED TO DEVELOP STERILE POWDERED MEDIA. ALTHOUGH THE LIQUID FORM PROVIDES CONVENIENCE, IT HAS SEVERAL DRAWBACKS: SHORT SHELF LIFE, BATCH-TO-BATCH VARIABILITY, VULNERABILITY TO TEMPERATURE EXTREMES… more
Company: American Biotechnology Co Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: THE GOAL OF THIS PROJECT WILL BE TO SCREEN NEW DERIVATIVES OF L-ASCORBIC ACID ADDUCTS CLASSIFIED AS METHYLFURYLBUTYROLACTONES, ALSO REFERRED TO AS NAFOCARE B. WORKING IN COLLABORATION WITH A SYNTHETIC ORGANIC CHEMISTRY GROUP AT WEST VIRGINIA UNIVERSITY, WE HAVE DETERMINED THAT THE PARENT COMPOUND,… more
Company: American Biotechnology Co Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: AND ITS POTENTIAL APPLICATION TO HUMAN HYBRIDOMA TECHNOLOGY.THIS PROJECT INVOLVES DETERMINING THE ABILITY OF A NEW CLASS OF SYNTHETIC BIOLOGICAL RESPONSE MODIFIERS (BRM) KNOWN AS METHYLFURYLBUTYROLACTONES (MFBL) TO AUGMENT THE PRODUCTION OF LYMPHOKINES (IL-2, B-CELL GROWTH FACTOR, AND IMMUNE… more
Company: American Biotechnology Co Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: ALTHOUGH INVESTIGATION INTO BIOLOGICAL RESPONSE MODIFIERS HAS INCREASED RECENTLY, MOST OF THE EFFORT HAS BEEN TOWARDS POTENTIATING THE HOST'S CELL-MEDIATED IMMUNITY. DATA ACCUMULATED BY OUR LABORATORIES INDICATE THAT THE METHYLFURYLBUTYROLACTONE (MFBL) CLASS OF COMPOUNDS REPRESENTS NEW SYNTHETIC… more
Company: American Health Sciences Corpo Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: AMERICAN HEALTH SERVICES CORPORATION HAS DEVELOPED A SERIES OF SOFTWARE PROGRAMS WHICH IS MARKETED UNDER THE TRADEMARK SENTRY HEALTH SURVEILLANCE. THIS SOFTWARE IS PART OF AN INTEGRATED SYSTEM DESIGNED TO ASSIST MEDICAL PERSONNEL IN THE MANAGEMENT OF MEDICAL INFORMATION IN OCCUPATIONAL AND… more
Company: AMT, INC. Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: THE PROVEN CLINICAL EFFECTIVENESS OF CISPLATIN AS WELL AS SEVERAL SECOND GENERATION ANALOGS HAS ESTABLISHED THE ROLE OF METAL COORDINATION COMPOUNDS IN CANCER CHEMOTHERAPY. COMPLEXES OF METALS OTHER THAN PLATINUM HAVE BEEN OFTEN POORLY DESIGNED BECAUSE THEY WERE MODELED AFTER THE ACTIVE PLATINUM… more
Company: AMT, INC. Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: THE OBJECTIVE OF THIS STUDY IS TO SYNTHESIZE, CHARACTERIZE, AND EVALUATE BIOLOGICAL PROPERTIES OF POLYMERIC PLATINUM COMPLEXES IN AN EFFORT TO ENHANCE SOLUBILITY AND STABILITY WHILE REDUCING TOXICITY AND OBTAINING GREATER SUSTAINED ACTIVITY THAN THAT FOUND WITH ACTIVE, STRUCTURALLY RELATED,… more
Company: Applied Genetics, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: A GROUP OF HUMAN TUMOR CELL STRAINS HAS BEEN IDENTIFIED THAT IS MORE SENSITIVE TO GROWTH INHIBITION PRODUCED BY HUMAN INTERFERON THAN ARE OTHER TUMOR CELL STRAINS OR NORMAL HUMAN FIBROBLASTS. THIS GROUP OF TUMOR STRAINS, DESIGNATED THE MER-PHENOTYPE, SHARES A BIOCHEMICAL DEFECT IN DNA REPAIR. THESE… more
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