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Agency:HHS
Phase:Phase I
Program:STTR
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Displaying 26 – 50 of 1450 Awards
Company: L2 DIAGNOSTICS, LLC Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): All forms of diabetes are characterized by the death of insulin producing cells. In Type 1 diabetes (T1D), this leads to the reliance on exogenous insulin for survival. In addition, there is cell loss in T2D and inindividuals who lose islet or pancreas… more
Company: LNKCHEMSOLUTIONS Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION: The goal of the proposed project is to develop a biocompatible ultrafine particle-based vector system for the intranasal delivery of clozapine for the pharmacological therapy of treatment- resistant schizophrenic disorders and their associatedsuicidal behavior. The rationale behind the… more
Company: MEDICAL IMAGING APPLICATIONS, LLC Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Aortic aneurysms and dissections are a cause of frequently preventable death for over 13,000 people annually in the US alone. Many more patients live under a constant threat of a catastrophic aortic event from atherosclerotic or congenital causes. Therefore,… more
Company: MEDSHAPE SOLUTIONS, INC. Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): 10.3 million Bioprosthetic heart valves (BHV) have been implanted since 1980 in the United States alone, but the solution for a durable, non-calcifying bioprosthesis still eludes us. High rates of structural failures and rapid calcificationin BHVs, has veered a… more
Company: Mound Laser & Photonics Center, Inc. Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Each year in the US, approximately 600,000 total knee replacement (TKR) surgeries are performed at a total annual cost of 15B and nearly 4.5M Americans are currently living with a TKR implant. The survival rate of TKRdevices declines dramatically after ten years… more
Company: Ocean Nano Tech LLC Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Chest pain in patients presenting to the emergency department (ED) present a clinical dilemma: transfer for emergent coronary revascularization, admit overnight for cardiac telemetry and stress testing, or discharge home with medical follow-up. In this proposal,… more
Company: PARALLEL CONSULTING, LLC Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Motor vehicle crashes are the leading cause of death and injury for teens, accounting annually for over 3000 deaths, 100 times as many injuries, and over 14 billion dollars in associated costs. The CDC has identified traffic crashes and associated injuries as a… more
Company: POLARIS HEALTH DIRECTIONS, INC. Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Although the USPHSTF, SAMHSA, the CDC, and NIAAA have affirmed the central role that healthcare providers play in screening, brief intervention, and referral to treatment (SBIRT) for alcohol abuse, translation of theserecommendations to clinical practice… more
Company: RADIANT CREATIVE GROUP, LLC Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant Adolescent and young adult (AYA) hematopoietic stem cell transplantation (HSCT) patients face a variety of well-documented physical and emotional challenges. In addition to undergoing a life-threatening procedure that involves an intense treatment regimen and… more
Company: RADIANT CREATIVE GROUP, LLC Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): The goal of this 3 year Fast-Track STTR is to develop and evaluate a home-based intervention ('it's Your Game- Family') to provide age-appropriate sexual health life skills education and training for children (11-14 years) and to enhance… more
Company: REGENEREX, LLC Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): We have developed a protocol that reproducibly induces transplantation tolerance in individuals undergoing a living related donor kidney transplant. Three subjects have been off all immunosuppression for 10 months, 2 months, and 1 month respectively and have… more
Company: SCOUT DIAGNOSTICS Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): The major barriers to preventing or treating Alzheimer's disease (AD) are its unknown pathogenesis/etiology and the lack of an objective, sensitive and specific biomarker of the disease, particularly at the early stageswhen therapeutic interventions would… more
Company: Southeast TechInventures Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Invasive aspergillosis (IA) caused by the fungus Aspergillus fumigatus is the most frequent fungal cause of death in immunocompromised patients. The number of patients at risk for developing IA is steadily increasing due to advances in medicine. Early and… more
Company: TECHLAB, INC. Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): The NIAID Category B priority pathogen Entamoeba histolytica is a public health threat, especially as a cause of diarrhea in travelers to and immigrants from endemic areas, men who have sex with men, and children in thedeveloping world where it is in the top 5… more
Company: Transgenomic, Inc. Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Ninety percent of all pancreatic cancers are pancreatic ductal adenocarcinoma (PDAC). PDAC diagnosis is difficult, usually occurring in the late stages of disease. Patients with these advanced tumors typically respondpoorly to therapy. Post diagnosis, median… more
Company: VALA SCIENCES, INC. Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Monitoring physiology of individual cardiomyocytes in high throughput has not been reported. The inability to perform high throughput physiological measurements limits many basic and applied studies, including the use of stem cell derived cardiomycoytes in… more
Company: VASCULAR PHARMACEUTICALS Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): The long-term objective of the proposed study is to develop a monoclonal antibody that inhibits the progression of diabetic retinopathy. Insulin-like growth factor-I (IGF-I) has been implicated in both endothelial dysfunction as well as the proliferative phase of… more
Company: VENTRIA BIOSCIENCE Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): An acute or cumulative overdose of acetaminophen (APAP), following either therapeutic overdose or suicide attempts, can cause severe liver damage with the potential to progress to liver failure. APAP overdose accounts for more than 56,000 emergency room visits, 2… more
Company: VIRTUALLY BETTER, INC. Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Overweight and obesity are major health problems, affecting over two-thirds of US adults. Standard behavioral treatments (SBT), which are the gold standard for mild and moderate obesity, have been adapted forInternet delivery to facilitate dissemination… more
Company: BUFFALO BIOLABS, LLC Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Rhabdomyosarcoma (RMS) is a childhood malignant tumor and is thought to arise due to the arrest of skeletal muscle differentiation (myogenesis) program. It accounts for 3.5% of all malignancies in children. Despite multimodality therapeutic treatment approaches,… more
Company: BUFFALO BIOLABS, LLC Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Mortality from pancreatic ductal adenocarcinoma (PDA) is close to 100% due to the absence of effective treatment approaches. This proposal is focused on determining the therapeutic potential of a new class of candidateanti-cancer agents named Curaxins (CXs) for… more
Company: VIDASYM, INC. Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Twenty-six million people in America have chronic kidney disease (CKD). Diabetes is by far the leading cause of CKD (diabetic nephropathy), accounting for 44% of new cases of dialysis (in 2005). Current treatments including ACE inhibitors for CKD patients mainly… more
Company: CARDIALEN, INC. Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Sudden cardiac death is a major cause of death around the world, with approximately 400,000 sudden deaths per year in the United States, more than are attributed to lung cancer, breast cancer, or AIDS. It is often caused by ventricular fibrillation (VF) and… more
Company: SORRENTO THERAPEUTICS, INC. Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Using mouse monoclonal antibodies (mAbs) raised against the mediators of quorum sensing (QS), the Auto-Inducing Peptides (AIPs), researchers at The Scripps Research Institute (TSRI) have demonstrated that S. aureus infections can be prevented in animal challenge… more
Company: BEST MEDICAL INTERNATIONAL, INC. Agency/Program/Year/Phase: HHS / STTR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Radiation oncology patients receive highly complicated treatments such as intensity modulated radiation therapy (IMRT), volumetric modulated arc therapy, stereotactic radiosurgery and stereotactic body radiation therapy using clinical linear accelerators.… more
Displaying 26 – 50 of 1450 Awards
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