Abstract:DESCRIPTION (provided by applicant): Otoreflectance (OR) is a new class of hearing test instruments utilizing acoustic signals presented and recorded in the ear canal. OR instruments address limitations in existing screening and diagnostic instruments in such areas as: (1) detecting otitis media,… more
Abstract:DESCRIPTION (provided by applicant): Acetaminophen is widely used for treatment of pain and/or fever in the elderly. This dual action is sometimes contraindicated. In many instances, pain needs to be controlled without masking the symptomatic fever (e.g., fever due to infection during the… more
Abstract:DESCRIPTION (provided by applicant): Alcohol use increases when students transition from high school to college, making the late high school years a critical window of opportunity for intervention. This project will develop an intervention that targets high school juniors and seniors and their… more
Abstract:DESCRIPTION (provided by applicant): Teens are using Ecstasy (MDMA) and other "party drugs" such as Ketamine, Rohypnol, and GHB at younger ages and in contexts that extend beyond the rave or dance party venues. Polydrug use is the norm and consequences include damage to brain cells, physiological… more
Abstract:DESCRIPTION (provided by applicant): This is a Phase I STTR application to develop a laboratory test for the diagnosis and monitoring of patients with thrombotic thrombocytopenic purpura (TTP). As there is no reliable, controlled laboratory test, TTP must be diagnosed on clinical grounds alone. Thus… more
Abstract:DESCRIPTION (provided by applicant): The efficacy of molecular chaperones as adjuvants for the induction of anti-tumor immunity has been demonstrated in many laboratories over the last two decades. Similarly, the exploration of the therapeutic use of poxviruses in cancer treatment has a long and… more
Abstract:DESCRIPTION (provided by applicant): Approximately 80,000 Americans sustain acute tears of the anterior cruciate ligament (ACL) of the knee each year, with associated healthcare costs estimated at roughly 1 billion dollars annually. Surgical reconstruction followed by an extended rehabilitation… more
Abstract:DESCRIPTION (provided by applicant):
We propose to develop a novel dual FRET molecular beacons technology for the early detection of cancer in living cells with high specificity, sensitivity and efficiency. Molecular beacons (MBs) are single-stranded oligonucleotides with a stem-loop hairpin… more
Abstract:DESCRIPTION (provided by investigator): Essential hypertension (EH) affects one out of four adults and is a primary risk factor for coronary heart disease (CHD), the leading cause of death in the US. Essential hypertension (EH) has its patho-biologic origins in childhood. Since blood pressure (BP)… more
Abstract:completion, the entire course will provide a professional certificate with
continuing nursing education contact hours or can be transferred as academic
credit in an undergraduate-nursing program. The model for the OCPP to be
developed in this project has three… more
Abstract:DESCRIPTION (provided by applicant): The primary goal of the current research will be to select the best recombinant form of one of two naturally occurring human igM antibodies demonstrated to stimulate remyelination to further develop for clinical testing in inflammatory demyelinating disease, such… more
Abstract:DESCRIPTION (provided by applicant): This project develops A2A adenosine receptor (A2AAR) agonists as adjuncts to antibiotics for the treatment of anthrax septicemia. It responds to the urgent need for better treatment of highly lethal infections by this bioterrorism/biowarfare agent. Phase I has… more
Abstract:epsis syndrome is the 11th leading cause of death in the United States ( about 900,000 new cases per year) with a mortality of about 35 percent. The need for adjunctive therapies is urgent. In Phase I of this SBIR award we documented the anti-inflammatory effects of adenosine A2A receptor (A2AAR)… more
Abstract:DESCRIPTION (provided by applicant): Androgen blockage therapy may relieve the symptom of an advanced, localized prostate tumor; however, once the tumor evolves into a hormone-refractory stage, there is no effective treatment. A continuous activation of AR by antiandrogens (used in androgen blockage… more
Abstract:Argolyn Bioscience Inc. is an early stage biotechnology company that creates novel peptide drugs and diagnostics with greatly improved intrinsic pharmaceutical properties through substitution of non-natural amino acid analogues for arginine (Arg) or lysine (Lys). In proof-of concept studies thus far… more
Abstract:DESCRIPTION (provided by applicant): The brain peptide neurotensin (NT) and its active derivative NT [8-13] function as endogenous neuroleptics. Stable NT derivatives that cross the blood brain barrier therefore have significant potential for development as a new class of non-dopamineric… more
Abstract:DESCRIPTION (provided by applicant) This project will develop an artificial intelligence to provide the core functionality for virtual reality and computer based treatments for anxiety disorders. The use of artificial intelligence offers a number of advantages over existing treatments: (1)… more
Abstract:DESCRIPTION (provided by applicant): Cardiovascular disease is the leading cause of death in the United States and other developed countries. The treatment of cardiovascular disease often involves surgically bypassing occluded segments of blood vessels with human saphenous vein grafts. Approximately… more
Abstract:DESCRIPTION (provided by applicant): One in nine women suffer from pelvic floor dysfunction, including urinary incontinence and vaginal wall or uterine prolapse (VUP). Stress urinary incontinence (SUI) affects 38% of women over the age of 65 years and over 13 million women in the United States.… more
Abstract:DESCRIPTION (provided by applicant): We have developed a plant-based adjuvant/carrier:antigen fusion technology that offers significant advantages over conventional injectable vaccination regimes including: safety, mucosal efficacy, ease of delivery, rapid scalability, unlimited supply potential,… more
Abstract:DESCRIPTION (provided by applicant): In this Phase II STTR project, the investigators plan to extend their successful Phase I feasibility demonstration to the development and manufacture of an RF body coil plus phased array receive system for use in high field clinical and research MRI systems. In… more
Abstract:Fine Needle Aspiration Biopsies (FNAB) are widely performed due to their minimally invasive nature, low cost, and rapid turn around time for the diagnosis of various mass lesions such as cancer and infection. With increasingly, their use is expected to increase further mainly due to the escalating… more
Abstract:Description(provided by applicant): Candida is the third leading cause of
catheter-related nosocomial bloodstream infections. Indwelling devices have
been shown to support colonization and biofilm formulation by Candida.
Intravenous lines are the most frequent indwelling device and are the… more
Abstract:DESCRIPTION (provided by applicant): Topical corticosteroids are useful treatment modalities for numerous dermatologic conditions. Most topical corticosteroids are applied in a cream or ointment vehicle, which require multiple applications, are subject to inadvertent removal, and can be… more
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