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Agency:HHS
Phase:Phase I
Program:STTR
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Displaying 1326 – 1350 of 1573 Awards
Company: SHENASA MEDICAL Agency/Program/Year/Phase: HHS / STTR / 2001 / 1
Abstract: DESCRIPTION: The overall research objective is demonstration of acceptance in living animals, and of optical performance in primate eyes , of an elliptical accommodative intra-ocular lens (EAIOL).… more
Company: SIMPRES, INC. Agency/Program/Year/Phase: HHS / STTR / 2001 / 1
Abstract: For over 4 million Americans with Alzheimer's disease and related disorders (ADRD), there is no effective therapy to interrupt or slow disease progression. Negative behaviors, apathy and sadness, communicate confusion, pain and discomfort impose tremendous burden on family and other caregivers. Our… more
Company: SLEEP-WAKE SYSTEMS, INC. (SWS) Agency/Program/Year/Phase: HHS / STTR / 2001 / 1
Abstract: DESCRIPTION: (Verbatim from the Applicant's Abstract) Driver vigilance lapses are a major contributor to motor vehicle accidents which often result in closed-head injuries , spinal cord transection, and other major medical traumata with high degrees of morbidity and… more
Company: ST. CHARLES PHARMACEUTICALS Agency/Program/Year/Phase: HHS / STTR / 2001 / 1
Abstract: DESCRIPTION(adapted from applicant's abstract): Acetaminophen, a nonsteroidal anti-inflammatory drug (NSAID), is widely used for treatment of pain and/or fever in the elderly. This dual action is sometimes contraindicated. In many instances pain needs to be controlled without… more
Company: SYNERGY PHARMACEUTICALS, INC. Agency/Program/Year/Phase: HHS / STTR / 2001 / 1
Abstract: DESCRIPTION (provided by applicant): The over-all goal of this "fast track" proposal is to develop a new class of orally available compounds for the treatment of chronic human hepatitis B virus (HBV) infection through a "proof of principle" Phase I/IIa Human clinical… more
Company: SYNERGY PHARMACEUTICALS, INC. Agency/Program/Year/Phase: HHS / STTR / 2001 / 1
Abstract: DESCRIPTION (Applicant's Abstract): Alpha-1 antitrypsin (al-AT) deficiency is a relatively common genetic disorder. A subgroup of deficient individuals develops chronic liver disease and hepatocellular carcinoma. The liver injury is caused by the toxic effect of the mutant… more
Company: THREE RIVERS HOLDINGS, LLC Agency/Program/Year/Phase: HHS / STTR / 2001 / 1
Abstract: DESCRIPTION (adapted from applicant's abstract): The activity level of people tends to decrease after a spinal cord injury. Studies have reported that daily wheelchair propulsion activity level of an individual with a spinal cord injury (SCI) is not sufficient to maintain or… more
Company: Thromgen, Inc. Agency/Program/Year/Phase: HHS / STTR / 2001 / 1
Abstract: DESCRIPTION (Applicant's Description Verbatim): The hypothesis of this proposal is that a thrombin inhibitor that selectively interferes with platelet activation will be an important therapeutic agent in the management of acute coronary syndromes. Thromgen, Inc. is… more
Company: TIGEN PHARMACEUTICALS Agency/Program/Year/Phase: HHS / STTR / 2001 / 1
Abstract: DESCRIPTION (provided by applicant): Based on the extensive data generated during the phase I portion of our studies, there is sufficient and compelling information to support the further development of the highly lipophilic and blood-stable topoisomerase inhibitor, DB-67.… more
Company: TIGEN PHARMACEUTICALS Agency/Program/Year/Phase: HHS / STTR / 2001 / 1
Abstract: DESCRIPTION (PROVIDED BY APPLICANT): DB-67 is a promising new silatecan (silylcamptothecin) analog that displays superior blood stability relative to the FDA-approved camptothecin congeners, topotecan and CPT- 11. DB-67 also exhibits a high degree of anti-cancer potency… more
Company: TISSUEGENESIS, INC. Agency/Program/Year/Phase: HHS / STTR / 2001 / 1
Abstract: DESCRIPTION (Verbatim from Applicant): The objective of this Phase I protocol is to develop a novel approach for the repair of articular cartilage using gene enhanced tissue engineering (GETE). Successful clinical repair of articular cartilage continues to be elusive. The… more
Company: TK TX COMPANY Agency/Program/Year/Phase: HHS / STTR / 2001 / 1
Abstract: DESCRIPTION (provided by the applicant): Acute inflammation is necessary for host defense but can also cause organ injury and dysfunction. The NF-kB transcription factor complex is critical for regulation of acute inflammation by controlling expression of a number of key… more
Company: TRANSFUSION AND TRANSPLANTATION TECH Agency/Program/Year/Phase: HHS / STTR / 2001 / 1
Abstract: The primary objective of these studies is to develop a novel device for rapid, cost-effective, and completely automated pretransfusion compatibility testing. This device will be of interest to Transfusion Medicine services and Blood Banks because it will improve testing throughput while cutting… more
Company: TUMOREX, INC. Agency/Program/Year/Phase: HHS / STTR / 2001 / 1
Abstract: DESCRIPTION (provided by applicant): Animal experiments have shown that the polymeric form of fibronectin, sFN, is an effective systemic anti-metastatic agent. The sFN polymer is formed by treating soluble fibronectin with a fragment from its first type III repeat… more
Company: ULEX CORPORATION Agency/Program/Year/Phase: HHS / STTR / 2001 / 1
Abstract: DESCRIPTION (provided by applicant): Cryptosporidium parvum is a significant cause of diarrheal disease of human and veterinary importance worldwide. There is currently no effective, specific therapy approved for cryptosporidiosis. The overall goal of this project is to develop… more
Company: VECTORLOGICS, INC. Agency/Program/Year/Phase: HHS / STTR / 2001 / 1
Abstract: DESCRIPTION (provided by applicant): The long-range goal of this research project is to develop a novel and effective strategy for transduction of human dendritic cells (DC) for the purposes of genetic anti-tumor immunization. To accomplish this goal, we will develop an… more
Company: Visigen Biotechnologies, Inc. Agency/Program/Year/Phase: HHS / STTR / 2001 / 1
Abstract: DESCRIPTION (Applicant's abstract): A first step toward the development of a method to sequence a single DNA molecule in real-time is proposed. Engineering a polymerase to act as a direct molecular sensor of DNA base identity, coupled with the synthesis of appropriately modified… more
Company: VITRON, INC. Agency/Program/Year/Phase: HHS / STTR / 2001 / 1
Abstract: DESCRIPTION (Adapted from the Investigator's Abstract): The main objective of this grant proposal is to use precision-cut tissues slices from genetically-modified mice as an in vitro system for rapid assessment for potential chemical toxicities. The Phase I… more
Company: AMPAC BIOTECHNOLOGY Agency/Program/Year/Phase: HHS / STTR / 2001 / 1
Abstract: DESCRIPTION (Provided by Applicant): An investigation is proposed exploring the use of biochemical reagents to improve fatigue resistance of intervertebral disc tissue. While not well quantified, the capacity of spinal tissue to withstand repetitive loading is a critically… more
Company: MOLECULAR EXPRESS, INC. Agency/Program/Year/Phase: HHS / STTR / 2001 / 1
Abstract: The eventual goal of the current research is to develop probes for in vivo imaging of gene expression and for in vivo targeting of cells for killing or remediation. The current proposal describes a novel nucleic acid probe design that will provide the basis of the new technology required for these… more
Company: ABACUS MANAGEMENT TECHNOLOGIES, LLC Agency/Program/Year/Phase: HHS / STTR / 2000 / 1
Abstract: N/A
Company: ACCESS PHARMACEUTICALS, INC. Agency/Program/Year/Phase: HHS / STTR / 2000 / 1
Abstract: N/A
Company: Acorda Therapeutics, Inc. Agency/Program/Year/Phase: HHS / STTR / 2000 / 1
Abstract: N/A
Company: ADENOSINE THERAPEUTICS, LLC Agency/Program/Year/Phase: HHS / STTR / 2000 / 1
Abstract: N/A
Company: ADENOSINE THERAPEUTICS, LLC Agency/Program/Year/Phase: HHS / STTR / 2000 / 1
Abstract: N/A
Displaying 1326 – 1350 of 1573 Awards
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