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Company: MOLECULAR DESIGN INTERNATIONAL, INC. Agency/Program/Year/Phase: HHS / SBIR / 1987 / 2
Abstract: THE LONG-TERM OBJECTIVE OF THIS PROJECT IS TO DEVELOP A COMMERCIAL PRODUCT FOR THE TOPICAL TREATMENT OF ACNE AND SKIN DISEASES. THE SPECIFIC AIM OF THE PROPOSAL IS TO INVENT A PRODRUG THAT CAN BE USED EFFECTIVELY AND SAFELY FOR THE TOPICAL TREATMENT OF ACNE. SINCE ISOTRETINOIN (13-CIS-RETINOIC ACID,… more
Company: Pellissippi International Inc. Agency/Program/Year/Phase: HHS / SBIR / 1987 / 1
Abstract: N/A
Company: Electrochemical Systems, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: N/A
Company: CTI SERVICES, INC. Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: A TWO-DIMENSIONAL PHOTON-COUNTING POSITION ENCODER IS PROPOSED FOR POSITION EMISSION TOMOGRAPHY (PET) 1. A METHOD OF CONTROLLING THE SPATIAL DISTRIBUTION OF PHOTONS FROM BISMUTH GERMANATE SCINTILLATORS, 2. THE USE OF ALL-DIGITAL PHOTON COUNTING FOR PROCESSING THE PHOTOMULTIPLIER SIGNAL, AND 3. THE… more
Company: CTI SERVICES, INC. Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: THE DEVELOPMENT OF AN AUTOMATED SYNTHESIS MODULE (ASM) FOR THE PRODUCTION OF OXYGEN-15 LABELED BUTANOL IS PROPOSED. OXYGEN-15LABELED BUTANOL IS THE ""GOLD STANDARD'' FOR CEREBRAL BLOOD FLOW MEASUREMENT BUT BECAUSE OF THE SHORT HALF-LIFE OF OXYGEN-15 (2 MINUTES) THE SYNTHESIS MUST BE PERFORMED IN A… more
Company: CTI SERVICES, INC. Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: WE PROPOSE TO DEVELOP AN AUTOMATED CHEMISTRY SYSTEM TO WORK FROM THE TARGET OF THE CTI MEDICAL CYCLOTRON. THE SYNTHESIS WILL BE 16-BETAMETHOXY-17-ALPHA-IODOVINYLESTRADIOL. THE MATERIAL HAS PROVEN TO BE ONE OF THE MOST ACTIVE STEROID RECEPTOR SITE AGENTS TO DATE AND SHOULD PROVE VALUABLE FOR THE… more
Company: CTI SERVICES, INC. Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: A NEW TWO-DIMENSIONAL POSITION ENCODER IS PROPOSED FOR PET WITH POSITION RESOLUTION BETTER THAN 3 MILLIMETERS. THE NEW DETECTOR INCLUDES 32 BISMUTH GERMANATE (BGO) SCINTILLATION CRYSTALS MOUNTED ON A LIGHT GUIDE. THE LIGHT GUIDE PROVIDES A SQUARE ROOT SEPARATION OF THE LIGHT DISTRIBUTION FROM EACH… more
Company: CTI SERVICES, INC. Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: AN AUTOMATIC SYNTHESIS MODULE FOR THE PRODUCTION OF F-18 FLUORODEOXYGLUCOSE IS PROPOSED. THIS METABOLIC ANALOG HAS BEEN EXTENSIVELY USED IN THE POSITRON EMISSION TOMOGRAPHIC INVESTIGATIONS OF CEREBRAL AND MYOCARDIAL METABOLIC RATES, AND IS A HIGHLY DESIRABLE AGENT TO BE READILY AVAILABLE IN A PET… more
Company: MOLECULAR DESIGN INTERNATIONAL, INC. Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: N/A
Company: Jcl Clinical Research Corp Agency/Program/Year/Phase: HHS / SBIR / 1984 / 1
Abstract: THE PAST DECADE HAS SEEN A GREAT IMPETUS IN THE SEARCH FOR TUMOR MARKERS FOR THE DETECTION AND MANAGEMENT OF CANCER. THIS SEARCH HAS LED TO THE DISCOVERY OF SEVERAL OTHER CARCINOFETAL PROTEINS SUCH AS VARIENTS OF CEA AND ALPHA FETOPROTEINS. THE TUMOR MARKER, TENNESSEE ANTIGEN, APPEARS TO DIFFER… more
Company: Jcl Clinical Research Corp Agency/Program/Year/Phase: HHS / SBIR / 1984 / 1
Abstract: A NEW TUMOR-ASSOCIATED ANTIGEN, CALLED TENNESSEE ANTIGEN (TAG), HAS BEEN ISOLATED FROM 95% OF 154 PRIMARY HUMAN GASTRAINTESTINAL TUMORS. IN 208 PATIENTS WITH COLORECTAL CARCINOMA, 81% SHOWED ELEVATED LEVELS OF TAG IN THEIR SERUM. IN THIS PROPOSAL, TAG WILL BE ISOLATED FROM EXTRACT OF ADENOCARCINOMA… more
Company: Technical Resource Group Agency/Program/Year/Phase: HHS / SBIR / 1984 / 1
Abstract: THE PROPOSED PROJECT IS CONSISTENT WITH THE INNOVATIVE RESEARCH GOALS OF THE NIH/NCI/DRCCA CHEMOPREVENTION PROGRAM. ITS AIMS ARE: (A) TO DEVELOP A PILOT DATA BASE ON CANCER CHEMOPREVENTION TESTING IN EXPERIMENTAL ANIMALS THAT MAY BE USED AS A MODEL FOR ANY FUTURE DATA BASE DEVELOPMENT EFFORTS, AND… more
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