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Agency:HHS
Program:SBIR
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Displaying 27951 – 27975 of 29995 Awards
Company: Sphinx Biotechnologies Corp Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: THE LONG TERM GOALS ARE TO DEVELOP A SIMPLE, RAPID AND INEXPENSIVE ASSAY FOR THE IDENTIFICATION OF TUMOR PROMOTING COMPOUNDS PRESENT IN THE ENVIRONMENT. THE PROPOSED METHOD CAPITALIZES ON RECENT MOLECULAR FINDINGS ON THE MECHANISM BY WHICH TUMOR PROMOTERS REGULATE THE EXPRESSION OF SPECIFICGENES.… more
Company: Standard Scientifics Inc. Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: N/A
Company: Sts Duotex Inc. Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: IN 1984 AN NIH CONSENSUS CONFERENCE RECOMMENDED COMMUNITY BASED CHOLESTEROL SCREENING PROGRAMS TO EVALUATE HYPERCHOLESTEROLEMIA IN THE CONTEXT OF ITS ASSOCIATION WITH INCREASED HEART ATTACKS. THERE IS A DEVELOPING LITERATURE THAT THE APOLIPOPROTEINS A-1 AND B ARE BETTER MEASURES OF RISK THAN HDL AND… more
Company: STRATAGENE Agency/Program/Year/Phase: HHS / SBIR / 1988 / 2
Abstract: DNA SEQUENCING REQUIRES A SIGNIFICANT AMOUNT OF THE HUMAN EFFORT INVOLVED IN MODERN BIOMEDICAL RESEARCH. METHODS TO STREAMLINE THE TECHNIQUE WILL HAVE GREAT VALUE. STRATAGENE,INC. PROPOSES SEVERAL NEW VECTOR SYSTEMS THAT WILL FACILITATE THE RAPID CONSTRUCTION OF TEMPLATES FOR DNA SEQUENCING. THE… more
Company: STRATAGENE Agency/Program/Year/Phase: HHS / SBIR / 1988 / 2
Abstract: CHROMOSOMAL JUMPING HAS BEEN PROPOSED AS A RAPID TECHNIQUE FOR ORDERING LARGE SEGMENTS OF THE GENOME, INCREASING THE SPEED AT WHICH GENES ASSOCIATED WITH HEREDITABLE DISEASES INHUMANS CAN BE ISOLATED. TECHNICAL DIFFICULTIES ASSOCIATED WITH THE CONSTRUCTION OF THE NECESSARY JUMPING AND JUNCTION… more
Company: STRATAGENE Agency/Program/Year/Phase: HHS / SBIR / 1988 / 2
Abstract: GAUCHER DISEASE AFFECTS 20,000 INDIVIDUALS IN THE UNITED STATES. GENE FREQUENCY FOR THIS DISEASE IS PARTICULARLY HIGH IN THE ASHKENAZIC JEWISH POPULATION, IN WHICH 1 OUT OF 20 INDIVIDUALS IS A CARRIER. IT IS MORE COMMON THAN TAY-SACHS DISEASE, FOR WHICH A SUCCESSFUL CARRIER SCREENING PROGRAM EXISTS.… more
Company: Sullivan Veterinary Clinic Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: PROBLEMS ASSOCIATED WITH "IN VIVO" CULTURE OF EARLY STAGES OF MICROMANIPULATED EMBRYOS FROM LARGE DOMESTIC ANIMALS INCLUDE: 1) VARIOUS TECHNICAL STEPS OF AGAR EMBEDDATION THATARE LABOR INTENSIVE; 2) INCOMPLETE AGAR COATING OF THE EMBRYO RESULTING IN INVASION OF ALIEN CELLS AND/OR DISPERSALOF… more
Company: Sullivan Veterinary Clinic Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: PROBLEMS ASSOCIATED WITH COMMERCIAL EMBRYO TRANSFER IN SWINE INCLUDE DIFFICULTIES IN THE SELECTION OF SUITABLE RECIPIENTS, REDUCED PREGNANCY RATES, REDUCED REPRODUCTIVE EFFICIENCY AND REDUCED ACCEPTANCE BY THE COMMERCIAL SWINE INDUSTRY. TRANSPLANTATION OF DISTINGUISHABLE EMBRYOS INTO MATED… more
Company: Sweet Dreems Inc. Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: N/A
Company: SYMBIOTECH, INC. Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: THE INTERFACE BETWEEN TWO CONTIGUOUS, IMMISCIBLE LIQUID PHASES CAN BE ESTABLISHED WITHIN THE MICROPORES OF A NEW TYPE OF POLYMERIC MEMBRANE. THESE KINDS OF MEMBRANES IN THEFORM OF TINY HOLLOW FIBERS WILL BE INVESTIGATED FOR CONDUCTING LIQUID-LIQUID EXTRACTION AS A FIRST PURIFICATION STAGE IN THE… more
Company: Synergen Inc Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: SEVERAL CLINICALLY IMPORTANT BETA-LACTAM ANTIBIOTICS ARE PRODUCED THROUGH CONDENSATION OF D-(-)-ALPHA-AMINOPHENYLACETIC ACID WITH PENAM AND CEPHEM NUCLEI IN MULTI-STEP CHEMICAL PROCESSES. AN EFFICIENT ENZYMATIC PROCESS FOR THE SYNTHESIS OF THESE ANTIBIOTICS WOULD LEAD TO INCREASED PRODUCT YIELDS AND… more
Company: Synergen Inc Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: THE OVERALL GOAL OF THE PROPOSED RESEARCH IS TO PROVIDE A SPECIFIC, PRACTICAL MEANS FOR INACTIVATING C5A IN PATIENTS AT RISK OF ADULT RESPIRATORY DISTRESS SYNDROME (ARDS). C5A IS A KEY CONTRIBUTORY, POSSIBLY NECESSARY FACTOR IN THE PATHOLOGICAL COURSE OF ARDS. THE PROTEINS CAPABLE OF INACTIVATING… more
Company: SYNTHETIC GENETICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: THE EFFECTIVE SYNTHESIS AND USE OF ENZYMATICALLY STABLE OLIGONUCLEOTIDE ETHYLTRIESTERS AND METHYLPHOSPHONATES IN SELECTIVELY INHIBITING PROTEIN SYNTHESIS IN CULTURED CELLS HAS BEEN DEMONSTRATED. RELATIVELY HIGH EXTERNAL CONCENTRATIONS ARE REQUIRED FOR EFFECTIVE PROTEIN SYNTHESIS INHIBITION DUE IN… more
Company: T & B BIOCLONE, INC. Agency/Program/Year/Phase: HHS / SBIR / 1988 / 2
Abstract: MONOCLONAL ANTIBODIES SPECIFIC FOR A HUMAN LUNG TUMOR-ASSOCIATED GLYCOPROTEIN ANTIGEN (GP-160) WILL BE USED TO DEVELOP AND TEST A CYTOTOXIC PROGNOSTIC IMMUNOASSAYS. THE GP-160 IS A MEMBRANE-ASSOCIATED GLYCOPROTEIN THAT IS FOUND IN SIGNIFICANT LEVELS ON SEVERAL MAJOR TYPES OF HUMAN LUNG TUMORS… more
Company: TANOX, INC. Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: N/A
Company: TECHNICAL RESEARCH ASSOC., INC. Agency/Program/Year/Phase: HHS / SBIR / 1988 / 2
Abstract: A FOUR-ELEMENT FEASIBILITY STUDY IS PROPOSED TO EVALUATE A NOVEL IDEA FOR PROVIDING URINARY BLADDER CONTINENCE TO INCONTINENT INDIVIDUALS, ESPECIALLY THE AGED. THE DEVICE IS A NONSURGICALLY INSERTED FLEXIBLE SEAL. MICTURITION CAN BE INITIATED BY AN EXTERNAL SEAL CONTROLLER. BECAUSE THE DEVICE CAN BE… more
Company: TECHNICAL RESEARCH ASSOC., INC. Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: TRA PROPOSES TO APPLY NUCLEAR MAGNETIC RESONANCE IMAGING (MRI) TECHNIQUES TO INVESTIGATE PERFUSION OF BLOOD IN THE ORGANS. THE AIM OF THIS PROJECT IS TO DEVELOP A MODEL OF PERFUSION AND TO ESTABLISH PROCEDURES AND FORMALISMS FOR OBTAINING INFORMATION ABOUT THE SPECIFIC PERMEABILITY AND VOID FRACTION… more
Company: TECHNICAL RESEARCH ASSOC., INC. Agency/Program/Year/Phase: HHS / SBIR / 1988 / 2
Abstract: IT IS PROPOSED TO APPLY NOVEL ULTRASOUND TECHNOLOGY TO THE DEVELOPMENT OF IMPROVED CENTRIFUGATION EQUIPMENT. THIS NEW DEVICE WILL USE INCLINED SURFACES IN CONJUNCTION WITH ULTRA-SOUND FORCE FIELDS TO SUBSTANTIALLY INCREASE SEDIMENTATION. BECAUSE THIS EQUIPMENT CAN PRODUCE EQUIVALENT SEPARATION WITH… more
Company: Tecmag, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1988 / 2
Abstract: THE GOAL OF THIS PROJECT IS TO DEVELOP AN ULTRAHIGH RESOLUTION NUCLEAR MAGNETIC RESONANCE (NMR) IMAGER (IN VIVO NMR MICROSCOPE) CAPABLE OF A RESOLUTION OF AT LEAST 10 MICRONS. DURING PHASE I, A SET OF GRADIENT COILS WITH A RISE TIME OF ABOUT 100 AND AN RF PROBE OF REDUCED DIAMETER (38 MM) WILL BE… more
Company: Tekmat Corp Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: NUMEROUS IMPLANTABLE BIOSENSORS HAVE BEEN DEVELOPED, BUT NONE HAVE REACHED COMMERCIAL VIABILITY DUE TO SALINE CORROSION OVER EXTENDED PERIODS. A COATING TECHNIQUE IS PROPOSED WHICH WILL COMBINE THE STRONG ADHERENCE OF PLASMA POLYMERIZED THIN FILMS WITH THE EASE AND SIMPLICITY OF DIP COATINGS. DURING… more
Company: The Fertility Testing Laborato Agency/Program/Year/Phase: HHS / SBIR / 1988 / 2
Abstract: SPERM MOTION ANALYSES AND AUTOMATED SEMEN ANALYSES ARE PRESENTLY BEING PERFORMED BY COMPUTERIZED SYSTEMS. HOWEVER,THESE SYSTEMS ARE EXPENSIVE ($35,000-$45,000) AND THEY ARE NOT COST EFFECTIVE FOR MOST LABORATORIES. FURTHERMORE, IT IS STILL UNCLEAR WHETHER THE MEASUREMENTS THAT ARE DERIVED FROM THESE… more
Company: Thoratec Laboratories Corp Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: A NEW CARDIAC VALVE FABRICATED FROM A NOVEL POLYURETHANE MATERIAL HAS BEEN FABRICATED AND TESTED IN VITRO. THESE PRELIMINARY TESTS INDICATE THAT THIS DEVICE ID DURABLE (NO FAILURES IN TESTS LASTING AT LEAST 200 MILLION CYCLES) AND POSSESSES HEMODYNAMIC CHARACTERISTICS COMPARABLE TO CURRENTLY… more
Company: Thies Technology Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: THE CENTRAL PURPOSE OF THIS RESEARCH IS TO DEVELOP A FLEXIBLE SYSTEM FOR SELECTIVE DELIVERY OF FLUORESCENT DYES, PHOTOACTIVE AGENTS, AND DRUGS TO SUBPOPULATIONS OF NEURONS DEEP WITHIN THE RODENT NERVOUS SYSTEM IN VIVO. A NOVEL LATEX NANOSPHERE DELIVERY SYSTEM (LNDS) WILL BE DEVELOPED AND REFINED TO… more
Company: Touchstone Applied Science Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: N/A
Company: Tplr Inc Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: A METHOD HAS BEEN DEVELOPED TO HELP LEGAL PROFESSIONALS INVOLVED WITH PRODUCT LIABILITY CASES EVALUATE THE ADVERSE HEALTH EFFECTS ATTRIBUTABLE TO TOBACCO USE. IN PHASE I ONLYTWO OF THE MANY WELL DOCUMENTED DISEASE AND TOBACCO ASSOCIATIONS ARE EXPLORED: (1) ACTIVE SMOKING AND LUNG CANCER, AND (2)… more
Displaying 27951 – 27975 of 29995 Awards
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