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Displaying 29526 – 29550 of 31916 Awards
Company: Biomol Research Laboratoryt Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: THE GOAL OF THE PROPOSED RESEARCH IS TO DEVELOP A HIGHLY SENSITIVE AND SPECIFIC RADIOIMMUNOASSAY FOR PLATELET ACTIVATING FACTOR (PAF). PAF IS A LIPID MEDIATOR PRODUCED BY A VARIETY OF INFLAMMATORY CELLS SUCH AS NEUTROPHILS, PLATELETS, MACROPHAGES, EOSINOPHILS, AND VASCULAR ENDOTHELIAL CELLS. PAF… more
Company: BIOPORE, INC. Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: DEPSITE ADVANTAGES OF DISEASE CONTROL, FROZEN HUMAN SPERM HAS BEEN RARELY USED UNIVERSALLY FOR DONOR ARTIFICIAL INSEMINATION BECAUSE OF PERCEIVED LOW FERTILITY. GLYCEROL (WHICH MAY BE CONTRACEPTIVE IN HUMANS AS WITH OTHER SPECIES) AND EGG YOLK PROTEIN (WHICH MAY BE ANTIGENIC) CAN BE REMOVED BY… more
Company: BIOPURE CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: BIOPURE CORPORATION HAS SUCCESSFULLY MANUFACTURED A POLYMERIZED BOVINE HEMOGLOBIN SOLUTION WHICH PHYSIOLOGICALLYOXYGENATES AS WELL AS OR BETTER THAN RED BLOOD CELLS. KEY PERFORMANCE CHARACTERISTICS INCLUDE BETTER 0(2)/CO(2) EXCHANGE AT THE CELLULAR LEVEL THAN FRESH HUMAN BLOOD. THE PRODUCT IS… more
Company: Bioquant, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: N/A
Company: Bioresources Laboratories Inc Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: THE TECHNOLOGY OF PRODUCING HYBRIDOMAS AND OTHER CLONED CELL LINES WHICH SECRETE IMMUNOREACTIVE SUBSTANCES, SUCH AS MONOCLONAL ANTIBODIES (MABS), IS NOW COMMANDING ATTENTION INALL FIELDS OF BIOLOGY. A PARTICULARLY IMPORTANT APPLICATIONFOR MABS IS THE DIAGNOSIS AND TREATMENT OF HUMAN TUMORS. THIS… more
Company: Biostatistical Programming Associates, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: N/A
Company: Biosyne Corp. Agency/Program/Year/Phase: HHS / SBIR / 1988 / 2
Abstract: THE PRIMARY OBJECTIVE OF THSES STUDIES IS TO DETERMINE THE FEASIBILITY OF USING THE CLONED LUX GENE SYSTEM ISOLATED ON A PLASMID EXPRESSION VECTOR FROM LUMINOUS MARINE BACTERIA AND EXPRESSED IN E. COLI (OR POSSIBLY OTHER BACTERIA) TO DETECT TOXIC SUBSTANCES IN WATER. NUMEROUS TOXIC… more
Company: Biotechnica Diagnostics Inc Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: THE USE OF ANTIBIOTIC THERAPY FOR INFECTION MANAGEMENT HAS INCREASED DRAMATICALLY IN THE AREA OF PERIODONTAL DISEASE AS AN ADJUNCT TO SCALING AND SURGERY TREATMENT. WITH THE EMERGENCE OF ANTIBIOTIC USE IN PERIODONTAL DISEASE CARE, ALMOST NO WORK HAS BEEN DONE IN ASSESSING THE DEVELOPMENT OF… more
Company: Biotechnica Diagnostics Inc Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: THE ROLE OF EIKENELLA CORRODENS, FUSOBACTERIUM NUCLEATUM, AND WOLINELLA RECTA AS PATHOGENS ASSOCIATED IN DESTRUCTIVE PERIODONTAL DISEASE HAS BEEN DESCRIBED IN A NUMBER OF STUDIES USING CULTURE BASED ASSAY SYSTEMS. THE STANDARD CULTURE METHODS ARE INADEQUATE FOR THE ROUTINE DIAGNOSIS OF THESE… more
Company: BIOTEK, INC. Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: THE OVERALL OBJECTIVE OF THE PROJECT IS TO DEVELOP A TRANSDERMAL DOSAGE FORM OF THE H(1)-BLOCKER CARBINOXAMINE FOR 24-HOUR CONTROL OF ALLERGIC RHINITIS. IN PHASE I THE FEASIBILITY OF SUCH DOSAGE WILL BE TESTED. IN VITRO TRANSDERMAL PENETRATION EXPERIMENTS WITH NUDE MOUSE SKINS, AS WELL AS IN VIVO… more
Company: BIOTEK, INC. Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: N/A
Company: Biotherm, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1988 / 2
Abstract: BIOTHERM, INC. PROPOSES TO DESIGN AND DEVELOP A PORTABLE SYSTEM, ANALOGOUS TO A HAND-HELD GLUCOSE METER, TO PERMIT RAPID, CONVENIENT BLOOD COAGULATION TESTING ON FRESHLY DRAWNSAMPLES FROM PATIENTS UNDERGOING ANTICOAGULANT THERAPY. THIS COST-EFFECTIVE SYSTEM WOULD BETTER HELP MEET THE NEEDS OF… more
Company: Biotrack Inc Agency/Program/Year/Phase: HHS / SBIR / 1988 / 2
Abstract: IN VITRO TESTS PROVIDE INDISPENSABLE INFORMATION TO MEDICAL PROFESSIONALS TO DIAGNOSE AND TREAT DISEASE. SUCH TESTS AREUSUALLY PERFORMED IN A LABORATORY REMOTE FROM THE PATIENT AND TAKE HOURS OR DAYS BEFORE RESULTS ARE AVAILABLE. BIOTRACK HAS DEVELOPED A NOVEL PROTHROMBIN TIME MONITOR DESIGNED FOR… more
Company: Biotronic Systems Corp. Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: THE LONG-TERM OBJECTIVE OF THIS RESEARCH IS TO DEVELOP A RAPID, COST-EFFECTIVE TEST FOR HUMAN ANTIBODIES TO HEPATITIS B CORE ANTIGEN (HEPBCA) WHICH WOULD BE SUITABLE FOR PREDONATION SCREENING OF BLOOD DONORS, AND WOULD UTILIZENOVEL CAPACITIVE AFFINITY SENSOR TECHNOLOGY. THE SPECIFIC AIMS OF THIS… more
Company: Biotronic Systems Corp. Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: N/A
Company: Birch And Davis Associates Agency/Program/Year/Phase: HHS / SBIR / 1988 / 2
Abstract: THE OBJECTIVE OF THIS PROJECT IS TO DEVELOP A GUIDEBOOK TO ASSIST STATE MEDICAID PROGRAMS IN CONTRACTING WITH AND MONITORING PREPAID PROVIDERS. IN PHASE I, A DETAILED OUTLINE OF THE GUIDE WILL BE PREPARED THROUGH COLLECTION OF EXISTING MATERIALS, INPUT FROM TWO VISITS TO SELECTED MEDICAID PROGRAMS,… more
Company: BONNIE WALKER AND ASSOCIATES Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: N/A
Company: BOSTON BIOTECHNOLOGY CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: THE LONG RANGE OBJECTIVE OF THIS RESEARCH IS TO REDUCE THE TOXICITY AND CARCINOGENICITY OF ASBESTOS BY DESFERROXAMINE TREATMENT, WHICH NEUTRALIZES THE CATALYTIC ACTIVITY OF THE ASBESTOS-CONTAINED IRON. IN PHASE I OF THIS PROJECT THE POSSIBILITY THAT DESFERROXAMINE TREATMENT CAN REDUCE… more
Company: California Biotechnology, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1988 / 2
Abstract: BASIC AND ACIDIC FIBROBLAST GROWTH FACTORS (FGF) ARE TWO PRIMARY MITOGENS FOR CAPILLARY ENDOTHELIAL CELLS. BOVINE BASIC FGF, ISOLATED FROM PITUITARIES, WILL BE USED IN RAT WOUND HEALING MODELS TO DETERMINE WHETHER THIS FACTOR CAN ACCELERATE THE RATE OF WOUND HEALING THROUGH PROMOTING ANGIOGENESIS.… more
Company: California Biotechnology, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1988 / 2
Abstract: THE OBJECTIVE OF THE PROPOSED RESEARCH IS FORMULATION OF AN EFFECTIVE SYNTHETIC SURFACTANT TO BE USED IN TREATMENT OF INFANT RESPIRATORY DISTRESS SYNDROME (RDS). RDS IS CAUSED BY INADEQUATE LEVELS OF LUNG SURFACTANT AT BIRTH, AND IS PRESENTLY TREATED BY ASSISTING THE NEWBORN WITH MECHANICAL… more
Company: California Biotechnology, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: THE LONG-TERM OBJECTIVE OF THE RESEARCH PROPOSED IN THIS SBIR GRANT APPLICATION IS TO DEVELOP A TRANSMUCOSAL DELIVERYTECHNOLOGY WHICH WILL ELIMINATE THE NECESSITY FOR THE PARENTERAL ADMINISTRATION OF PROTEIN AND PEPTIDE DRUGS. THEGOALS OF THE PHASE I PROGRAM ARE TO SYNTHESIZE, PHYSICALLY… more
Company: California Biotechnology, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: ALZHEIMER'S DISEASE IS A GROWING MEDICAL PROBLEM AFFLICTING 5% OF THE OVER-65 POPULATION IN THE US. DESPITE ITS PREVALENCE, NEITHER POSITIVE DIAGNOSES NOR EFFICACIOUS TREATMENT EXIST. DEFINITIVE DIAGNOSIS IS MADE ON AUTOPSY USING THE HISTOPATHOLOGICAL HALLMARKS OF THE DISEASE - FIBRILLAR AMYLOID… more
Company: Cambridge Biotech Corp.ora- Ti Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: N/A
Company: CAMBRIDGE NEUROSCIENCE Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: EXCITATORY AMINO ACIDS (EAAS) ARE IMPLICATED IN THE PATHOLOGY OF A NUMBER OF HUMAN NEUROLOGICAL DISORDERS, INCLUDING EPILEPSY, ISCHEMIC BRAIN DAMAGE, AND NEURODEGENERATIVE DISEASES SUCH AS HUNTINGTON'S DISEASE AND ALZHEIMER'S DISEASE. THE ROLE OF EAAS IN THESE DISORDERS APPEARS TO INVOLVE ABNORMALLY… more
Company: CAMBRIDGE NEUROSCIENCE Agency/Program/Year/Phase: HHS / SBIR / 1988 / 1
Abstract: N/A
Displaying 29526 – 29550 of 31916 Awards
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